1/3 A new RCT tested closed-loop automated oxygen control (CLAC) vs. manual oxygen adjustment in preterm ventilated infants. The aim is to compare how long infants stayed on mechanical ventilation. N= 69 infants (median GA 27 weeks) were randomized within 48 hours of ventilation start.

Angehängt: 1 Bild Gesundheitskompetenz stärken: #CharitéBerlin und Bosch Health Campus starten mit @karolinskainstitutet@mastodon.social die digitale Gesundheitsplattform „Sundi“. Sundi richtet sich an Menschen ab 55 Jahre und kombiniert wissenschaftlich geprüfte Gesundheitsinformationen mit einem virtuellen Gesundheitsassistenten. 🤖 Heute wurde die Plattform offiziell vorgestellt. 👏 👉 https://www.charite.de/service/pressemitteilung/artikel/detail/sundi_bosch_health_campus_und_charite_starten_digitales_praeventionsangebot_mit_ki_chatbot #Medizin #Forschung #Prävention #MedMastodon #Sundi

Many of my readers will remember the impressive results of the high-quality study by Paolo Manzoni, Manzoni P, et al. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial. JAMA. 2009;302(13):1421–8) which showed that routine supplementation of preterm infants with bovine lactoferrin (bLF) dramatically reduced late-onset sepsis. Many of us were quite excited with this finding, and launched our own studies, I performed a pilot in my NICU, hoping to use the data to get funding for a confirmatory trial (Barrington KJ, et al.

Rant… Identifying impactful early interventions by #RCT is important — but long‑term follow‑up is equally so. Over the last 50 years, only a handful of truly redefining interventions have emerged: antenatal steroids, surfactant, caffeine. 1/5

A new very large (for neonatology) RCT has just been published. Ojha S, et al. Full exclusively enteral fluids from day 1 versus gradual feeding in preterm infants (FEED1): a open-label, parallel-group, multicentre, randomised, superiority trial. Lancet Child Adolesc Health. 2025. Mothers were approached prior to preterm delivery, and babies were enrolled if they delivered between 30 and >33 weeks gestation, and were deemed clinically stable, prior to 3 hours of age. Prior to delivery the mothers either gave full written signed consent, or they verbally agreed to the study, in which case they had a full written consent later.