Severin Ronneau
@sronneau.bsky.social
Microbiologist at Rennes 🇫🇷 Alumnus of UNamur 🇧🇪, Imperial College London 🇬🇧 and Harvard Medical School 🇺🇸 Passionate about Bacterial Stress Responses
Happy to share our lastest story about the Stringent Response ! We show how host-relevant stress disrupts Fe-S cluster stability, tuning (p)ppGpp levels to control bacterial adaptation and trigger virulence.
Read more here 👉 www.biorxiv.org/content/10.1...
Read more here 👉 www.biorxiv.org/content/10.1...
Stress-Induced Iron-Sulfur Cluster Damage as a Conserved Trigger of the Stringent Response
Pathogenic bacteria rely on the stringent response to adapt to the complex and fluctuating conditions encountered within the host. However, the mechanisms by which the stringent response senses host-i...
www.biorxiv.org
July 30, 2025 at 10:53 AM
Happy to share our lastest story about the Stringent Response ! We show how host-relevant stress disrupts Fe-S cluster stability, tuning (p)ppGpp levels to control bacterial adaptation and trigger virulence.
Read more here 👉 www.biorxiv.org/content/10.1...
Read more here 👉 www.biorxiv.org/content/10.1...
Excited to share our latest work on antibiotic persistence ! We found that while bacteria intoxicated by host RNS are shielded from β-lactams, they still remain vulnerable to fluoroquinolones. Why? Check our new study : journals.plos.org/plospathogen...
Intoxication of antibiotic persisters by host RNS inactivates their efflux machinery during infection
Author summary By influencing the physiology of bacterial pathogens, the host environment can either limit or potentiate the effectiveness of antibiotics during infection. Recently, we demonstrated th...
journals.plos.org
February 29, 2024 at 8:54 PM
Excited to share our latest work on antibiotic persistence ! We found that while bacteria intoxicated by host RNS are shielded from β-lactams, they still remain vulnerable to fluoroquinolones. Why? Check our new study : journals.plos.org/plospathogen...
Reposted by Severin Ronneau
The HintonLab SalCom transcriptomic databases are back on online TODAY❗️#Salmonella
SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack
SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack
February 24, 2024 at 10:38 PM
The HintonLab SalCom transcriptomic databases are back on online TODAY❗️#Salmonella
SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack
SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/...
SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack
Highly recommend this excellent review from Katherine Cotten and Kimberly Davis about antibiotic persistence during infection. Really happy to see that we are moving forward in this challenging field !
Bacterial heterogeneity and antibiotic persistence: bacterial mechanisms utilized in the host enviro...
SUMMARYAntibiotic persistence, or the ability of small subsets of bacteria to survive prolonged
antibiotic treatment, is an underappreciated cause of antibiotic treatment failure.
Over the past decade...
journals.asm.org
December 22, 2023 at 10:23 AM
Highly recommend this excellent review from Katherine Cotten and Kimberly Davis about antibiotic persistence during infection. Really happy to see that we are moving forward in this challenging field !