SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia.
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...

Peer pressure shapes the gut: latest publication in @pnas.org by @lepuslapis.bsky.social, @zhaoshh.bsky.social from @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social with colleagues from @flatironinstitute.org and Princeton University. www.mpi-cbg.de/news-outreac...

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

This piece of work from my PhD is FRESHLY out of the oven in
@natureportfolio.nature.com
Nature Physics! It illustrates how architecture and active stress mutually regulate Criticality and exhibit Anderson Localization-like phenomenon. www.nature.com/articles/s41...

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...

It's an interesting phenomenon that some of the deepest questions about how life works have become what looks like impossibly obscure molecular biology stuck right at the back of Nature, which will never get covered by the science media. Like this. /1
www.nature.com/articles/s41...

Can using synthetic approaches to build biology help teach us the design principles of how embryos build themselves? 👷‍♀️🔧

If this is a question that interests you, come and share your thoughts at this Royal Society Workshop on Generative Biology

www.royalsoc.ac.uk/science-even...

Check out our new work!

The code for performing coherent structure analysis, along with the documentation, is available at sreejithsanthosh.github.io/FTLEhub/. Please feel free to reach out if you are interested in using this analysis for kinematic data in your system!

Collective cell migration is fascinating!
Some tissues behave like fluids (motile), others like solids (jammed).

Check out some papers exploring this topic in this thread.

Pretty much everything is fucked, but here is some beautiful and exciting science from @archaeon-alex.bsky.social and colleagues.

www.science.org/doi/10.1126/...

📣Check out our work led by @alex-plum.bsky.social ! We developed a mathematical framework for morphogen patterning in dynamic tissues, revealing key insights into how morphogenesis mediates cell-cell communication, morphogen compartmentalization and fate coordination. biorxiv.org/content/10.1...

Chuai, M., Serrano Nájera, G., Serra, M., Mahadevan, L., & Weijer, C. J. (2023). Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo. Science Advances, 9(1), eabn5429. https://doi.org/10.1126/sciadv.abn5429 #EpithelialMechanics

Our paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer" is now out in
@naturephysics.bsky.social :
rdcu.be/d5rTP

#BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling

Saransh will give the lab's first yeast talk since the birth of our lab at the #ASCB meeting 2024 in San Diego (Dec 14-18). Come to the 'Biological Size Control and Scaling' session this Saturday at 9:30 AM!

"The topology, shape and size of mitochondrial networks during the cell cycle in yeast"

Large-scale collective motion of epithelial cells not as a fluid, but as a polar elastic solid.
Our new study posted on Biorxiv:
www.biorxiv.org/content/10.1...

This app is so cool!