Dan Kliebenstein
@spicybotrytis.bsky.social
Dogs, Horses and Gardening, with a side of research on complexity and metabolic warfare in plants
Although to be clear, humility and ego coexist in all of us. That is part the of being human. It is simply can we acknowledge our ego and its existence. Pure humility is simply a thing of the saints and sages.
November 10, 2025 at 1:07 AM
Although to be clear, humility and ego coexist in all of us. That is part the of being human. It is simply can we acknowledge our ego and its existence. Pure humility is simply a thing of the saints and sages.
Totally agree, they get three practice exams that are built to reinforce and slightly extend the lecture. Have access to them all quarter.
November 8, 2025 at 5:23 PM
Totally agree, they get three practice exams that are built to reinforce and slightly extend the lecture. Have access to them all quarter.
I go further and say
Life in other planets could follow Mendel and never new DNA.
Use the height gene to discuss how large and small effect can coexist.
Walk them from one additive gene to two to three to 1000s to show how quant arises.
Life in other planets could follow Mendel and never new DNA.
Use the height gene to discuss how large and small effect can coexist.
Walk them from one additive gene to two to three to 1000s to show how quant arises.
November 8, 2025 at 2:47 PM
I go further and say
Life in other planets could follow Mendel and never new DNA.
Use the height gene to discuss how large and small effect can coexist.
Walk them from one additive gene to two to three to 1000s to show how quant arises.
Life in other planets could follow Mendel and never new DNA.
Use the height gene to discuss how large and small effect can coexist.
Walk them from one additive gene to two to three to 1000s to show how quant arises.
I wonder how many students ever get that message.
November 8, 2025 at 12:56 PM
I wonder how many students ever get that message.
I hope those ideas land with half the audience as they often come in with different ideas from previous classes so working to change rather than fill in a blank slate.
November 8, 2025 at 1:40 AM
I hope those ideas land with half the audience as they often come in with different ideas from previous classes so working to change rather than fill in a blank slate.
I'm not quite as confident in the dominance of regulation variation in plants, but that may be from a specialized metabolite view. A ton of the variation between plants, from species to genera, in my favorite traits is presence/absence of genes rather than differential regulation.
November 6, 2025 at 6:25 PM
I'm not quite as confident in the dominance of regulation variation in plants, but that may be from a specialized metabolite view. A ton of the variation between plants, from species to genera, in my favorite traits is presence/absence of genes rather than differential regulation.
If there is a whole transcriptome of GWA study in a paper how does that get applied to the distribution?
November 5, 2025 at 1:49 AM
If there is a whole transcriptome of GWA study in a paper how does that get applied to the distribution?
Any idea on how to get an official UCD transcript for first years when there are no courses taken?
November 4, 2025 at 9:16 PM
Any idea on how to get an official UCD transcript for first years when there are no courses taken?
I think it may be frequent, for the TPS reason and other genes, and we just rarely sample clades from multiple species to genotypes within species very well or often. That sampling design will be key to know how quick changes are happening.
November 4, 2025 at 3:06 PM
I think it may be frequent, for the TPS reason and other genes, and we just rarely sample clades from multiple species to genotypes within species very well or often. That sampling design will be key to know how quick changes are happening.
Lots of #secmet alter DNA methylation marks for unknown reasons. Almost feels like if you wave a wand and click heels three times that methylation shifts.
November 4, 2025 at 1:49 AM
Lots of #secmet alter DNA methylation marks for unknown reasons. Almost feels like if you wave a wand and click heels three times that methylation shifts.
"Crucially, students will need to develop sufficient expertise to identify when AI systems produce plausible but incorrect outputs — which poses a dilemma because this requires the very skills that AI is starting to replace."
Is it a dilemma if the solution is so easy to state?
Is it a dilemma if the solution is so easy to state?
November 3, 2025 at 6:44 PM
"Crucially, students will need to develop sufficient expertise to identify when AI systems produce plausible but incorrect outputs — which poses a dilemma because this requires the very skills that AI is starting to replace."
Is it a dilemma if the solution is so easy to state?
Is it a dilemma if the solution is so easy to state?
If I remember right, it simply a SNP within a active site that changes activity. Kind of like a lot of the terpene synthase variation where compounds come and go based on active site shifts.
November 3, 2025 at 5:18 PM
If I remember right, it simply a SNP within a active site that changes activity. Kind of like a lot of the terpene synthase variation where compounds come and go based on active site shifts.
From a different angle, I have never seen any academic (or athletic) group that is all or basically all male have the ability to focus on or get to the truth.
October 31, 2025 at 10:09 PM
From a different angle, I have never seen any academic (or athletic) group that is all or basically all male have the ability to focus on or get to the truth.
Did we really think it was dead and not alive with proteins, chemicals and proteins moving information and function all over? I'm not so sure about that headline sentence.
October 29, 2025 at 9:16 PM
Did we really think it was dead and not alive with proteins, chemicals and proteins moving information and function all over? I'm not so sure about that headline sentence.
I think that is simply known as the CNS business model. Press for the press release and assume scientists will fall in line to not be considered jerks.
October 28, 2025 at 3:41 AM
I think that is simply known as the CNS business model. Press for the press release and assume scientists will fall in line to not be considered jerks.
So to bacteria, plants are simply another environment albeit with a weird element of hierarchical information sharing across environments that gives a dash of predictive benefit at least transiently.
Close?
Close?
October 24, 2025 at 11:37 PM
So to bacteria, plants are simply another environment albeit with a weird element of hierarchical information sharing across environments that gives a dash of predictive benefit at least transiently.
Close?
Close?
I think that also extends to the organism, making a model of a wild plant predominantly co-evolving with one other organism in the face of the innumerable other interactions seems almost an impossible reflection of reality. I wonder if evoMPMi needs to shift to looking at the matrix of interactors.
October 24, 2025 at 10:51 PM
I think that also extends to the organism, making a model of a wild plant predominantly co-evolving with one other organism in the face of the innumerable other interactions seems almost an impossible reflection of reality. I wonder if evoMPMi needs to shift to looking at the matrix of interactors.
I wonder if anyone has done a meta analysis on comparing systems with equivalent tools and if community size is an additive effect on information learned or synergistic effect.
October 24, 2025 at 3:48 PM
I wonder if anyone has done a meta analysis on comparing systems with equivalent tools and if community size is an additive effect on information learned or synergistic effect.
Honestly, a lot consider me a noob to plant pathology.
October 23, 2025 at 6:32 PM
Honestly, a lot consider me a noob to plant pathology.
That depreciation cost is a kicker and why we could never justify a Mass-spec. Couldn't ever get a grant large enough to justify the cost to the benefit ratio. Fortunately we can do 1000s of samples at a time with a $800 paint-shaker.
October 23, 2025 at 5:21 PM
That depreciation cost is a kicker and why we could never justify a Mass-spec. Couldn't ever get a grant large enough to justify the cost to the benefit ratio. Fortunately we can do 1000s of samples at a time with a $800 paint-shaker.
That is where we (the lab) start but we feel like a majority of the MPMI community thinks option 2 is basically non-existent and there is lots of co-evolution.
October 23, 2025 at 5:18 PM
That is where we (the lab) start but we feel like a majority of the MPMI community thinks option 2 is basically non-existent and there is lots of co-evolution.