Greg Hayes
@soundgmh.bsky.social
Family | Music | Film | Surfing | http://imdb.me/greghayes | aKD #MIS_C #MISC May2020 #longcovidkids
How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease | Review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 4, 2025 at 5:31 AM
How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease | Review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
3 clusters =
1. Respiratory, overlapping
acute COVID-19
2. Shock/cardiac involvement
3. overlaps w/ Kawasaki disease and younger age
1. Respiratory, overlapping
acute COVID-19
2. Shock/cardiac involvement
3. overlaps w/ Kawasaki disease and younger age
April 9, 2025 at 3:46 AM
3 clusters =
1. Respiratory, overlapping
acute COVID-19
2. Shock/cardiac involvement
3. overlaps w/ Kawasaki disease and younger age
1. Respiratory, overlapping
acute COVID-19
2. Shock/cardiac involvement
3. overlaps w/ Kawasaki disease and younger age
I’m excited to be invited to attend and participate in CARRA’s Annual Scientific Meeting to share my family’s journey and discuss the challenges of understanding young developing immune systems and immune dysregulation.
#CARRA2025 #parentadvocate #caregiver #researcher
#CARRA2025 #parentadvocate #caregiver #researcher
April 2, 2025 at 3:36 AM
I’m excited to be invited to attend and participate in CARRA’s Annual Scientific Meeting to share my family’s journey and discuss the challenges of understanding young developing immune systems and immune dysregulation.
#CARRA2025 #parentadvocate #caregiver #researcher
#CARRA2025 #parentadvocate #caregiver #researcher
March 13, 2025 at 2:01 AM
Going into the OR -
Time moves so slow in the waiting room.
Time moves so slow in the waiting room.
February 11, 2025 at 5:43 PM
Going into the OR -
Time moves so slow in the waiting room.
Time moves so slow in the waiting room.
wisdom comes in many shapes and sizes. I’ve learned a lot from a lot of different people. I continue to learn the most from you, my son.
December 27, 2024 at 7:03 AM
wisdom comes in many shapes and sizes. I’ve learned a lot from a lot of different people. I continue to learn the most from you, my son.
Happy Holidays from our family to yours! May this season bring warmth, joy, and countless moments to cherish with the ones you love. Wishing you all the best as we step into the new year!
December 24, 2024 at 6:20 PM
Happy Holidays from our family to yours! May this season bring warmth, joy, and countless moments to cherish with the ones you love. Wishing you all the best as we step into the new year!
This study highlights the importance of a long-term multidisciplinary follow-up of children hospitalised with MIS-C, in order to detect the potential long-term sequelae in different areas of health
December 23, 2024 at 6:13 PM
This study highlights the importance of a long-term multidisciplinary follow-up of children hospitalised with MIS-C, in order to detect the potential long-term sequelae in different areas of health
December 19, 2024 at 3:29 AM
The number of Kawasaki Disease patients/month (both confirmed and unconfirmed) after the onset of the pandemic remained low, reflecting the reduced KD incidence during the pandemic. Additionally, the trends for both the confirmed and unconfirmed KD patients showed no seasonal variability.
December 8, 2024 at 8:26 AM
The number of Kawasaki Disease patients/month (both confirmed and unconfirmed) after the onset of the pandemic remained low, reflecting the reduced KD incidence during the pandemic. Additionally, the trends for both the confirmed and unconfirmed KD patients showed no seasonal variability.
A portion of the unconfirmed KD (who may have had exposure to COVID with or without documentation) and the unconfirmed MIS-C patients may have been patients who experienced a hyperinflammatory reaction that did not fully manifest as a confirmed case for either condition.
December 8, 2024 at 8:26 AM
A portion of the unconfirmed KD (who may have had exposure to COVID with or without documentation) and the unconfirmed MIS-C patients may have been patients who experienced a hyperinflammatory reaction that did not fully manifest as a confirmed case for either condition.
Why exclude KD patients with recent COVID infection from the study? This approach overlooks a critical subgroup—children who could offer additional insights into the spectrum of inflammatory responses in pediatric patients.
December 4, 2024 at 7:26 AM
Why exclude KD patients with recent COVID infection from the study? This approach overlooks a critical subgroup—children who could offer additional insights into the spectrum of inflammatory responses in pediatric patients.
Bellos, Santillo, @SanchoShimizu et al. identify an enrichment of rare, damaging variants in BTNL8 in MIS-C patients resulting in impaired Vγ4⁺ γδ T cell engagement associated with altered gut homeostasis which may contribute to the pathogenesis of MIS-C. hubs.la/Q02Z9_kK0
November 22, 2024 at 8:36 PM
Bellos, Santillo, @SanchoShimizu et al. identify an enrichment of rare, damaging variants in BTNL8 in MIS-C patients resulting in impaired Vγ4⁺ γδ T cell engagement associated with altered gut homeostasis which may contribute to the pathogenesis of MIS-C. hubs.la/Q02Z9_kK0
Long-COVID symptoms after multisystem inflammatory
syndrome in children during different pandemic waves
www.termedia.pl/Journal/-127...
Long-term Health Outcomes After Hospital Discharge Among Children Hospitalized for MIS-C or COVID-19 September 2021 to June ‘22
journals.lww.com/pidj/fulltex...
syndrome in children during different pandemic waves
www.termedia.pl/Journal/-127...
Long-term Health Outcomes After Hospital Discharge Among Children Hospitalized for MIS-C or COVID-19 September 2021 to June ‘22
journals.lww.com/pidj/fulltex...
November 20, 2024 at 5:26 AM
Long-COVID symptoms after multisystem inflammatory
syndrome in children during different pandemic waves
www.termedia.pl/Journal/-127...
Long-term Health Outcomes After Hospital Discharge Among Children Hospitalized for MIS-C or COVID-19 September 2021 to June ‘22
journals.lww.com/pidj/fulltex...
syndrome in children during different pandemic waves
www.termedia.pl/Journal/-127...
Long-term Health Outcomes After Hospital Discharge Among Children Hospitalized for MIS-C or COVID-19 September 2021 to June ‘22
journals.lww.com/pidj/fulltex...
The Spectrum of Postacute Sequelae of COVID-19 in Children: From MIS-C to Long COVID
pubmed.ncbi.nlm.nih.gov/38631806/?ut...
pubmed.ncbi.nlm.nih.gov/38631806/?ut...
November 20, 2024 at 5:26 AM
The Spectrum of Postacute Sequelae of COVID-19 in Children: From MIS-C to Long COVID
pubmed.ncbi.nlm.nih.gov/38631806/?ut...
pubmed.ncbi.nlm.nih.gov/38631806/?ut...
I did want to ask about the phrasing, “most kids recover with medical care.” While it’s true that many children improve, data shows that 20-50% of children with MIS-C experience ongoing symptoms. Here are some linked studies.
November 20, 2024 at 5:26 AM
I did want to ask about the phrasing, “most kids recover with medical care.” While it’s true that many children improve, data shows that 20-50% of children with MIS-C experience ongoing symptoms. Here are some linked studies.
Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells induce Tfh differentiation
Quite interesting preprint from Hal Hoffman’s group.
www.researchsquare.com/article/rs-5...
Quite interesting preprint from Hal Hoffman’s group.
www.researchsquare.com/article/rs-5...
November 18, 2024 at 2:58 AM
Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells induce Tfh differentiation
Quite interesting preprint from Hal Hoffman’s group.
www.researchsquare.com/article/rs-5...
Quite interesting preprint from Hal Hoffman’s group.
www.researchsquare.com/article/rs-5...
Macrophage Activation Syndrome in MIS-C | American Academy of Pediatrics
publications.aap.org/pediatrics/a...
publications.aap.org/pediatrics/a...
November 17, 2024 at 6:43 AM
Macrophage Activation Syndrome in MIS-C | American Academy of Pediatrics
publications.aap.org/pediatrics/a...
publications.aap.org/pediatrics/a...
“Antibiotic exposure has the powerful effect of skewing the composition of the intestinal microbiota, and we hypothesize that prior antibiotic exposure might be associated with increased severity of KD and the development of CALs due to aberrant changes in the intestinal microbiota of KD patients”
November 16, 2024 at 5:12 PM
“Antibiotic exposure has the powerful effect of skewing the composition of the intestinal microbiota, and we hypothesize that prior antibiotic exposure might be associated with increased severity of KD and the development of CALs due to aberrant changes in the intestinal microbiota of KD patients”
We should also recognize that children can experience long COVID, and it’s highly probable that MIS-C and long COVID exist on a spectrum of related conditions.
November 12, 2024 at 6:21 AM
We should also recognize that children can experience long COVID, and it’s highly probable that MIS-C and long COVID exist on a spectrum of related conditions.
Sensory neuroimmune interactions at the barrier | REVIEW
Detailing how sensory biology is informing mucosal neuroimmunology, even beyond neuroimmune interactions seen within the central and autonomic nervous systems.
www.mucosalimmunology.org/article/S193...
Detailing how sensory biology is informing mucosal neuroimmunology, even beyond neuroimmune interactions seen within the central and autonomic nervous systems.
www.mucosalimmunology.org/article/S193...
November 12, 2024 at 5:15 AM
Sensory neuroimmune interactions at the barrier | REVIEW
Detailing how sensory biology is informing mucosal neuroimmunology, even beyond neuroimmune interactions seen within the central and autonomic nervous systems.
www.mucosalimmunology.org/article/S193...
Detailing how sensory biology is informing mucosal neuroimmunology, even beyond neuroimmune interactions seen within the central and autonomic nervous systems.
www.mucosalimmunology.org/article/S193...