Greg Hayes
@soundgmh.bsky.social
Family | Music | Film | Surfing | http://imdb.me/greghayes | aKD #MIS_C #MISC May2020 #longcovidkids
By understanding the overlap between inflammatory diseases with shared genetic modulators, we can better ascertain the implications for other diseases with similar phenotypes.”
September 29, 2025 at 5:11 PM
By understanding the overlap between inflammatory diseases with shared genetic modulators, we can better ascertain the implications for other diseases with similar phenotypes.”
We propose that gut immunity may also be important in the development of KD, although further work is needed to elucidate this link.
September 29, 2025 at 5:11 PM
We propose that gut immunity may also be important in the development of KD, although further work is needed to elucidate this link.
Reposted by Greg Hayes
Notably, WTA is not a PAMP.
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
September 26, 2025 at 2:02 PM
Notably, WTA is not a PAMP.
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Uncovering the road to MIS-C…
-TGFβ links EBV to multisystem inflammatory syndrome in children-
Brilliant work by a massively brilliant team.
#LongCovid #MISC #KD
www.nature.com/articles/s41...
-TGFβ links EBV to multisystem inflammatory syndrome in children-
Brilliant work by a massively brilliant team.
#LongCovid #MISC #KD
www.nature.com/articles/s41...
TGFβ links EBV to multisystem inflammatory syndrome in children - Nature
Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
www.nature.com
September 5, 2025 at 6:51 PM
Moving forward it’s critical to learn from the little we do know about Systemic Auto Inflammatory Diseases (SAID) which has only started to be defined and recognized since Dan Kastner and colleagues at the NIH first coined the term in 1999.
September 4, 2025 at 1:42 AM
Moving forward it’s critical to learn from the little we do know about Systemic Auto Inflammatory Diseases (SAID) which has only started to be defined and recognized since Dan Kastner and colleagues at the NIH first coined the term in 1999.
Reposted by Greg Hayes
Adding to the conversation—in the same spirit, I think this recent paper is important:
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...
Systemic auto-inflammatory diseases, auto-immune diseases and immune deficiencies: From independent to overlapped diseases approach
Systemic AutoInflammatory Diseases (SAIDs), AutoImmune Diseases (AIDs), and Primary Immune Deficiencies (PIDs) were formely considered independent, ev…
www.sciencedirect.com
August 7, 2025 at 11:23 PM
Adding to the conversation—in the same spirit, I think this recent paper is important:
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...