Mitophagy defects also negatively alter the ER redox environment. Not the most profound statement, but ER-mito crosstalk/cascades are likely a very important contributor to diabetes!

Thank you and excellent question! Misfolded proinsulin and ER stress definitely will elicit mito changes. Akita mice also have mito structural defects. In other cell types, ER stress causes mito fusion (maybe to compensate)? We have not examined mitophagy in these models ourselves though.

True!!!

Congratulations Sara and team on the exciting new work!

Thank you so much, Martin!!! We really appreciate it.

Wow - super cool work @frisophagy.bsky.social! Congrats indeed! 🤩

My last post stuck in my drafts...finally, we are so grateful to the outstanding reviewers and editor for making our work better. And special thanks to @ella-maru.bsky.social for the beautiful images for the cover!