Sol Vendrell
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sol-uble.bsky.social
Sol Vendrell
@sol-uble.bsky.social
72 followers 72 following 4 posts
Postdoc at the @vincent-libis.bsky.social lab in Paris working on new antibiotic discovery 🧫
Interested in genetic elements of all kinds 🔀
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sol-uble.bsky.social
And we had the privilege of having a primer article written about our paper by #ColinHill and #AndreyShkoporov, immense respect! 🙇🏻‍♀️
plosbiology.org PLOS Biology @plosbiology.org · Apr 2
The biology and ecological impact of #phages in the mammalian gut are poorly understood. This Primer explores a @plosbiology.org study that provides a glimpse into the disruptive biology of the #Hankyphages, parasites of the ubiquitous Bacteroidaceae. 🧪 Primer: plos.io/3RukgtJ Paper: plos.io/41Rr22S
Schematic showing how Hankyphage has multiple mechanisms of generating randomness in its own and its bacterial host genomes. (1) RepCHP-dependent spontaneous induction of prophage, (2) incomplete packaging leading to defective virions and free tails in combination with low-level complete packaging and potential transduction events, (3) intrachromosomal transposition leading to genetic variation in the host genome, and (4) diversity generating retroelements within the phage genome impacting the host range of the phage. Created with BioRender.
April 3, 2025 at 6:43 PM
sol-uble.bsky.social
So happy to have published my PhD work! What a funky phage, it was a ride. Big thanks to @beatrizbeamud.bsky.social & @jmouradesousa.bsky.social for bringing their expertise into this story. And my mentors @jmghigolab.bsky.social & @dbikard.bsky.social 💪🏼
plosbiology.org PLOS Biology @plosbiology.org · Apr 1
How does the lysogenic-lytic cycle work in intestinal #bacteriophages? @sol-uble.bsky.social @dbikard.bsky.social @jmghigolab.bsky.social &co show that hankyphage produces defective viral particles & identify RepCHP as master repressor of this #phage's lytic cycle @plosbiology.org 🧪 plos.io/41Rr22S
Abnormal hankyphage virion morphology and incomplete DNA packaging. Negatively stained TEM micrographs of lysates of wildtype hankyphage-bearing Bacteroides thetaiotamicron strain jmh43 (left) and jmh43 in which RepCHP expression has been suppressed (center and right). Loose phage tails are indicated with black arrows.
April 3, 2025 at 2:00 PM