Sofie Lundgren
@sofielundgren.bsky.social
M.D./Ph.D at the University of Helsinki. Hematology, immunology, rogue T cells, somatic mutations.
Our findings not only map the unique immune landscape in AA but also reveal how innate & adaptive immunity converge in autoimmunity. Specifically targeting antigen-recognizing T cells, NK- or NK-like T cells holds a potential as a new therapeutic avenue.
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February 28, 2025 at 6:30 AM
Our findings not only map the unique immune landscape in AA but also reveal how innate & adaptive immunity converge in autoimmunity. Specifically targeting antigen-recognizing T cells, NK- or NK-like T cells holds a potential as a new therapeutic avenue.
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Viruses, such as CMV or EBV, have been speculated as AA triggers, for instance in this recent Blood publication by Hamza et al pubmed.ncbi.nlm.nih.gov/38277625/. In our cohort, we found evidence of viral involvement in only a handful of cases (4/70).
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February 28, 2025 at 6:30 AM
Viruses, such as CMV or EBV, have been speculated as AA triggers, for instance in this recent Blood publication by Hamza et al pubmed.ncbi.nlm.nih.gov/38277625/. In our cohort, we found evidence of viral involvement in only a handful of cases (4/70).
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IFNγ response was the dominant signal both in BM & in vitro, and it seems to mediate NK and CD8+ T cell activation in AA.
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February 28, 2025 at 6:30 AM
IFNγ response was the dominant signal both in BM & in vitro, and it seems to mediate NK and CD8+ T cell activation in AA.
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Unexpectedly, AA BM had abundant NK cells, and a subgroup of patients had more NK than CD8+ T cells. Co-culture experiments with autologous hematopoietic stem cells suggested that NK cells may prime target cells for T cell mediated killing.
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February 28, 2025 at 6:30 AM
Unexpectedly, AA BM had abundant NK cells, and a subgroup of patients had more NK than CD8+ T cells. Co-culture experiments with autologous hematopoietic stem cells suggested that NK cells may prime target cells for T cell mediated killing.
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The AA-specific TCR motifs were enriched in CD8+ T cells with the NK-like T cell phenotype.
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February 28, 2025 at 6:30 AM
The AA-specific TCR motifs were enriched in CD8+ T cells with the NK-like T cell phenotype.
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These TCR motifs were validated in independent validation cohort and were associated with clinical variables, such as HLA 6pLOH and treatment response. Like in the recent Science article, we were able to discriminate AA patients from healthy controls www.science.org/doi/10.1126/...
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February 28, 2025 at 6:30 AM
These TCR motifs were validated in independent validation cohort and were associated with clinical variables, such as HLA 6pLOH and treatment response. Like in the recent Science article, we were able to discriminate AA patients from healthy controls www.science.org/doi/10.1126/...
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Most autoimmune diseases lack known target antigens. Since T cells recognize their antigens with their TCR in a key-lock manner, we identified 238 TCRβ motifs that could help uncover public antigen targets in AA.
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February 28, 2025 at 6:30 AM
Most autoimmune diseases lack known target antigens. Since T cells recognize their antigens with their TCR in a key-lock manner, we identified 238 TCRβ motifs that could help uncover public antigen targets in AA.
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NK-like CD8+ T cells have been linked to dysfunctional or senescent states in acute myeloid leukemia. Our findings in autoimmunity contrast these findings, highlighting the inhibitory tumor microenvironment as a potential reason for this discrepancy. pubmed.ncbi.nlm.nih.gov/38776511/
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February 28, 2025 at 6:30 AM
NK-like CD8+ T cells have been linked to dysfunctional or senescent states in acute myeloid leukemia. Our findings in autoimmunity contrast these findings, highlighting the inhibitory tumor microenvironment as a potential reason for this discrepancy. pubmed.ncbi.nlm.nih.gov/38776511/
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CD8+ T cells are known to destroy hematopoietic stem cells in AA. We found that CD8+ T cells in AA BM expressed NK receptors, potentially affecting their ability to react to self-antigens. This “NK-like” phenotype has been previously described in e.g. coeliac disease and cancer.
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February 28, 2025 at 6:30 AM
CD8+ T cells are known to destroy hematopoietic stem cells in AA. We found that CD8+ T cells in AA BM expressed NK receptors, potentially affecting their ability to react to self-antigens. This “NK-like” phenotype has been previously described in e.g. coeliac disease and cancer.
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AA is a deadly autoimmune disease, treated with hematopoietic stem cell transplantation or immunosuppression. The drugs wipe out the whole T cell compartment, predisposing patients to severe infections. Yet, only ~⅔ of patients respond, highlighting the pressing need for better therapies.
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February 28, 2025 at 6:30 AM
AA is a deadly autoimmune disease, treated with hematopoietic stem cell transplantation or immunosuppression. The drugs wipe out the whole T cell compartment, predisposing patients to severe infections. Yet, only ~⅔ of patients respond, highlighting the pressing need for better therapies.
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