David Solecki
@so-lets-kilab70.bsky.social
Posting our lab life studying the neuronal cytoskeleton and chromatin with cool microscopes🔬Proud #GenX, #firstgen college, #intj @RITscience @stonybrooku Alum
Verified: https://orcid.org/0000-0001-8481-0403
Verified: https://orcid.org/0000-0001-8481-0403
Pinned
To all the FirstGen students out there today & this difficult week: I was once in your shoes: a first-gen, raised in foster care, in a home making less than $20k/year. Stability came from my Depression-era grandparents, financial aid connected the dots, and mentors lifted me up. You can make it too.
Reposted by David Solecki
Help chromatin friends! Looking for a paper and AI is failing. Study used CRISPR tech to perturb a variety of chromatin regulators to determine their functional importance on a number of different TFs. Main outcome was that different TFs = different chromatin regulators
November 29, 2025 at 5:13 PM
Help chromatin friends! Looking for a paper and AI is failing. Study used CRISPR tech to perturb a variety of chromatin regulators to determine their functional importance on a number of different TFs. Main outcome was that different TFs = different chromatin regulators
Thanksgiving update:
Turkey’s brined.
Pie’s baked.
Pickle slice just hit metaphase.
Breaks from cutting edge science? Never heard of ’em.
Happy Thanksgiving y’all
🥒🔬🦃
#Thanksgiving #CellBiology #NerdHumor #Science
Turkey’s brined.
Pie’s baked.
Pickle slice just hit metaphase.
Breaks from cutting edge science? Never heard of ’em.
Happy Thanksgiving y’all
🥒🔬🦃
#Thanksgiving #CellBiology #NerdHumor #Science
November 27, 2025 at 10:37 PM
Thanksgiving update:
Turkey’s brined.
Pie’s baked.
Pickle slice just hit metaphase.
Breaks from cutting edge science? Never heard of ’em.
Happy Thanksgiving y’all
🥒🔬🦃
#Thanksgiving #CellBiology #NerdHumor #Science
Turkey’s brined.
Pie’s baked.
Pickle slice just hit metaphase.
Breaks from cutting edge science? Never heard of ’em.
Happy Thanksgiving y’all
🥒🔬🦃
#Thanksgiving #CellBiology #NerdHumor #Science
Reposted by David Solecki
Thrilled to share the first full paper from @AntLabUNAM! 🐜💥
Our paper examines how queen and worker harvester ants differ in ovarian morphology and gene expression, shedding light on the ovary as a hub for multiple physiological systems, not just reproduction. Check it out! rdcu.be/ePNP8
Our paper examines how queen and worker harvester ants differ in ovarian morphology and gene expression, shedding light on the ovary as a hub for multiple physiological systems, not just reproduction. Check it out! rdcu.be/ePNP8
Age, caste, and social context shape ovarian morphology and transcriptomic profiles in red harvester ants
npj Aging - Age, caste, and social context shape ovarian morphology and transcriptomic profiles in red harvester ants
rdcu.be
November 20, 2025 at 3:29 PM
Thrilled to share the first full paper from @AntLabUNAM! 🐜💥
Our paper examines how queen and worker harvester ants differ in ovarian morphology and gene expression, shedding light on the ovary as a hub for multiple physiological systems, not just reproduction. Check it out! rdcu.be/ePNP8
Our paper examines how queen and worker harvester ants differ in ovarian morphology and gene expression, shedding light on the ovary as a hub for multiple physiological systems, not just reproduction. Check it out! rdcu.be/ePNP8
Reposted by David Solecki
November 20, 2025 at 10:05 PM
November 20, 2025 at 10:05 PM
Reposted by David Solecki
This work is now out @pnas.org. Result of fantastic collaborations with @so-lets-kilab70.bsky.social and Jason vevea @St Jude. Look out for two cool fluorescent ligands.
November 16, 2025 at 5:11 AM
This work is now out @pnas.org. Result of fantastic collaborations with @so-lets-kilab70.bsky.social and Jason vevea @St Jude. Look out for two cool fluorescent ligands.
Reposted by David Solecki
Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain - Nature Communications
Synapses are diverse within a single neuron. Here, the authors present a method for single-cell synaptome imaging of endogenous protein subpopulations in the mouse brain, enabling spatial mapping of s...
www.nature.com
November 11, 2025 at 6:19 PM
Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...
#ThoughtfulThursday
Why does my AVATAR outside the lab have MORE GREY HAIR than real-life me? 😳
Is it:
✅ The avatar actually wrote ALL th3 grants?
✅ It’s aging in DOG YEARS from reviewer feedback?
✅ Or is it secretly running experiments at 3 AM?
What’s your theory?👇
#ScienceLife #LabHumor
Why does my AVATAR outside the lab have MORE GREY HAIR than real-life me? 😳
Is it:
✅ The avatar actually wrote ALL th3 grants?
✅ It’s aging in DOG YEARS from reviewer feedback?
✅ Or is it secretly running experiments at 3 AM?
What’s your theory?👇
#ScienceLife #LabHumor
November 6, 2025 at 4:47 PM
#ThoughtfulThursday
Why does my AVATAR outside the lab have MORE GREY HAIR than real-life me? 😳
Is it:
✅ The avatar actually wrote ALL th3 grants?
✅ It’s aging in DOG YEARS from reviewer feedback?
✅ Or is it secretly running experiments at 3 AM?
What’s your theory?👇
#ScienceLife #LabHumor
Why does my AVATAR outside the lab have MORE GREY HAIR than real-life me? 😳
Is it:
✅ The avatar actually wrote ALL th3 grants?
✅ It’s aging in DOG YEARS from reviewer feedback?
✅ Or is it secretly running experiments at 3 AM?
What’s your theory?👇
#ScienceLife #LabHumor
Y’all microscopy nerds will understand my evening’s drink….its a StayGold
November 2, 2025 at 3:14 AM
Y’all microscopy nerds will understand my evening’s drink….its a StayGold
🚨 GOVERNMENT SHUTDOWN? NO PROBLEM! 🇺🇸
Petroglyph National Monument is WIDE OPEN & the ancient trials are CALLING! 🔥 Epic fall vibes leg flexing in the desert 💪
#LandofEnchantment #Petroglyph #NewMexico #Hiking
Petroglyph National Monument is WIDE OPEN & the ancient trials are CALLING! 🔥 Epic fall vibes leg flexing in the desert 💪
#LandofEnchantment #Petroglyph #NewMexico #Hiking
November 1, 2025 at 7:22 PM
🚨 GOVERNMENT SHUTDOWN? NO PROBLEM! 🇺🇸
Petroglyph National Monument is WIDE OPEN & the ancient trials are CALLING! 🔥 Epic fall vibes leg flexing in the desert 💪
#LandofEnchantment #Petroglyph #NewMexico #Hiking
Petroglyph National Monument is WIDE OPEN & the ancient trials are CALLING! 🔥 Epic fall vibes leg flexing in the desert 💪
#LandofEnchantment #Petroglyph #NewMexico #Hiking
ZOINKS! 🐕💨
The lab just unmasked the real ghost haunting our data... it was LIAM all along! 👻🔬
Repost if this Mystery Machine rolls harder than your feed! 🚐🎃 #Halloween #FluorescenceFriday #Halloween2025 #ScoobyDoo
The lab just unmasked the real ghost haunting our data... it was LIAM all along! 👻🔬
Repost if this Mystery Machine rolls harder than your feed! 🚐🎃 #Halloween #FluorescenceFriday #Halloween2025 #ScoobyDoo
October 31, 2025 at 3:38 PM
ZOINKS! 🐕💨
The lab just unmasked the real ghost haunting our data... it was LIAM all along! 👻🔬
Repost if this Mystery Machine rolls harder than your feed! 🚐🎃 #Halloween #FluorescenceFriday #Halloween2025 #ScoobyDoo
The lab just unmasked the real ghost haunting our data... it was LIAM all along! 👻🔬
Repost if this Mystery Machine rolls harder than your feed! 🚐🎃 #Halloween #FluorescenceFriday #Halloween2025 #ScoobyDoo
When chemistry meets neurons! Game-changing paper on multifunctional fluorescent ligands. Luke and Pratik built the nerdy toys; we got to play! Jason Vevea nailed biotin-HTL for mito magic. My lab rocked the JQ1 HTL to shuffle chromatin in mins. 1st collab win for our Neuronal Cell Biology Division.
October 28, 2025 at 4:57 PM
When chemistry meets neurons! Game-changing paper on multifunctional fluorescent ligands. Luke and Pratik built the nerdy toys; we got to play! Jason Vevea nailed biotin-HTL for mito magic. My lab rocked the JQ1 HTL to shuffle chromatin in mins. 1st collab win for our Neuronal Cell Biology Division.
Reposted by David Solecki
A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 27, 2025 at 9:43 PM
A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...
Kirby Campbell just dropped a mind-blowing presentation at #KIDS25! Using cutting-edge FIB-SEM & super-resolution datasets, he’s unveiled how neurons condense chromatin. AI + data science reveal new “flavors” of heterochromatin. Shoutout to the Abbas Shirinifard and NIAL #microscopymonday
October 27, 2025 at 8:10 PM
Kirby Campbell just dropped a mind-blowing presentation at #KIDS25! Using cutting-edge FIB-SEM & super-resolution datasets, he’s unveiled how neurons condense chromatin. AI + data science reveal new “flavors” of heterochromatin. Shoutout to the Abbas Shirinifard and NIAL #microscopymonday
Forget #MicroscopyMonday or #FluorescenceFriday — it’s #TrailblazingTuesday!
The lab’s latest flex: a live-cell imaging probe catching Ser2-phosphorylated RNA Pol II CTD in real time Watch transcriptional elongation light up living nuclei!
What’s the coolest thing you’ve seen under a microscope?
The lab’s latest flex: a live-cell imaging probe catching Ser2-phosphorylated RNA Pol II CTD in real time Watch transcriptional elongation light up living nuclei!
What’s the coolest thing you’ve seen under a microscope?
October 21, 2025 at 4:46 PM
Forget #MicroscopyMonday or #FluorescenceFriday — it’s #TrailblazingTuesday!
The lab’s latest flex: a live-cell imaging probe catching Ser2-phosphorylated RNA Pol II CTD in real time Watch transcriptional elongation light up living nuclei!
What’s the coolest thing you’ve seen under a microscope?
The lab’s latest flex: a live-cell imaging probe catching Ser2-phosphorylated RNA Pol II CTD in real time Watch transcriptional elongation light up living nuclei!
What’s the coolest thing you’ve seen under a microscope?
18 YEARS AGO, I kicked off a wild chase after the brain's biggest secrets, like it owed its blueprint to how it builds itself from scratch 🧠 Me + my fearless lab family turned curiosity into a powerhouse, probing frontiers. Shoutout to the St. Jude's vibe fueling breakthroughs over copycat science.
October 16, 2025 at 4:37 PM
18 YEARS AGO, I kicked off a wild chase after the brain's biggest secrets, like it owed its blueprint to how it builds itself from scratch 🧠 Me + my fearless lab family turned curiosity into a powerhouse, probing frontiers. Shoutout to the St. Jude's vibe fueling breakthroughs over copycat science.
🚨 Mind-blowing Brain Club alert! Liam Hallada just dropped a 🔥 stellar talk that hits pause on your brain mid-thought. He transformed heavy tech lifts into pure gold: revolutionary new imaging pipelines, bold fresh questions, and razor-sharp methods to decode how neurons wire up
#scicomm #CellBio
#scicomm #CellBio
October 15, 2025 at 7:31 PM
Reposted by David Solecki
Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
#HappyFluorescenceFriday!
#microscopycommunity- want to learn open source image analysis or share your knowledge to help others? We’ve got a FREE virtual workshop Nov 17-19! Now accepting workshop session applications!
Learn more & sign up: buff.ly/esGIotD
#microscopycommunity- want to learn open source image analysis or share your knowledge to help others? We’ve got a FREE virtual workshop Nov 17-19! Now accepting workshop session applications!
Learn more & sign up: buff.ly/esGIotD
September 23, 2025 at 3:48 PM
Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
Reposted by David Solecki
Field notes from a weekend PI at the #microscope: vesicle cargo lanes lighting up in real time like @FedEx. This is the ML1N PX domain in a fibroblast. Hot damn, there’s mind-blowing action under the surface of cells: this video shows 2 min of time 🤯 #Cellbio #MicroscopyMonday #SciArt #SciComm
September 22, 2025 at 3:42 PM
Field notes from a weekend PI at the #microscope: vesicle cargo lanes lighting up in real time like @FedEx. This is the ML1N PX domain in a fibroblast. Hot damn, there’s mind-blowing action under the surface of cells: this video shows 2 min of time 🤯 #Cellbio #MicroscopyMonday #SciArt #SciComm
Field notes from a weekend PI at the #microscope: vesicle cargo lanes lighting up in real time like @FedEx. This is the ML1N PX domain in a fibroblast. Hot damn, there’s mind-blowing action under the surface of cells: this video shows 2 min of time 🤯 #Cellbio #MicroscopyMonday #SciArt #SciComm
September 22, 2025 at 3:42 PM
Field notes from a weekend PI at the #microscope: vesicle cargo lanes lighting up in real time like @FedEx. This is the ML1N PX domain in a fibroblast. Hot damn, there’s mind-blowing action under the surface of cells: this video shows 2 min of time 🤯 #Cellbio #MicroscopyMonday #SciArt #SciComm
Reposted by David Solecki
Hey Keri, some nuclei wear their emotions on their chromatin 🤭 I’m sure this is not in any epigenetic text books. Ironically, I captured this on a Lattice Light Sheet microscope a few years back which protects cell from phototoxicity.
September 19, 2025 at 4:35 PM
Hey Keri, some nuclei wear their emotions on their chromatin 🤭 I’m sure this is not in any epigenetic text books. Ironically, I captured this on a Lattice Light Sheet microscope a few years back which protects cell from phototoxicity.
Hey Keri, some nuclei wear their emotions on their chromatin 🤭 I’m sure this is not in any epigenetic text books. Ironically, I captured this on a Lattice Light Sheet microscope a few years back which protects cell from phototoxicity.
September 19, 2025 at 4:35 PM
Hey Keri, some nuclei wear their emotions on their chromatin 🤭 I’m sure this is not in any epigenetic text books. Ironically, I captured this on a Lattice Light Sheet microscope a few years back which protects cell from phototoxicity.
Reposted by David Solecki
Lots of things hitting all at once so feeling a little underwater, and this image felt kind of like a self mirror for #FluorescenceFriday 🧠🔬🧪
September 19, 2025 at 3:50 PM
Lots of things hitting all at once so feeling a little underwater, and this image felt kind of like a self mirror for #FluorescenceFriday 🧠🔬🧪
Reposted by David Solecki
Multidisciplinary minds around one table at Solecki lab meeting. We channeled David Epstein’s Range to rethink a workhorse lab technique. Thinking loud, gesturing louder (classic me🙌). Ideas stretch far with a broad skilled team #LabLife #ScienceTribe #Science #Collaboration #scientists
September 16, 2025 at 4:41 PM
Multidisciplinary minds around one table at Solecki lab meeting. We channeled David Epstein’s Range to rethink a workhorse lab technique. Thinking loud, gesturing louder (classic me🙌). Ideas stretch far with a broad skilled team #LabLife #ScienceTribe #Science #Collaboration #scientists
Multidisciplinary minds around one table at Solecki lab meeting. We channeled David Epstein’s Range to rethink a workhorse lab technique. Thinking loud, gesturing louder (classic me🙌). Ideas stretch far with a broad skilled team #LabLife #ScienceTribe #Science #Collaboration #scientists
September 16, 2025 at 4:41 PM
Multidisciplinary minds around one table at Solecki lab meeting. We channeled David Epstein’s Range to rethink a workhorse lab technique. Thinking loud, gesturing louder (classic me🙌). Ideas stretch far with a broad skilled team #LabLife #ScienceTribe #Science #Collaboration #scientists