Sneh Harsh
@sneh84.bsky.social
A Drosophila enthusiast with a strong interest in disease modeling
Reposted by Sneh Harsh
Harsh, S., Liu, H. Y., Bhaskar, P. K., Rushlow, C., Bach, E. A. (2025). Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program. PLoS Biol, 23(12):e3003535 journals.plos.org/plosbiology/...
Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program
Somatic gonadal sex fate must be actively upheld throughout adulthood to support proper gametogenesis, but how do adult tissues maintain their sexual identity? This study identifies a post-transcripti...
journals.plos.org
January 5, 2026 at 10:19 PM
Harsh, S., Liu, H. Y., Bhaskar, P. K., Rushlow, C., Bach, E. A. (2025). Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program. PLoS Biol, 23(12):e3003535 journals.plos.org/plosbiology/...
I would also like to sincerely thank Artyom Kopp for writing such a beautiful primer on this work.
Maintaining sexual identity in adult flies is an ongoing commitment
In the gonad, sex is not an irrevocable commitment and requires active maintenance. A new study in PLOS Biology elucidates the molecular mechanisms that preserve sexual identity in the adult Drosophil...
dx.plos.org
January 7, 2026 at 11:35 PM
I would also like to sincerely thank Artyom Kopp for writing such a beautiful primer on this work.
Science conversations often chase buzzwords like cancer or disease-I once did too. Studying sex determination taught me that a “simple” basic question can reveal deep, far-reaching biology. Discovering Zelda’s role made it thrilling. Grateful to Erika Bach, colleagues, and my love for Drosophila.
Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program
Somatic gonadal sex fate must be actively upheld throughout adulthood to support proper gametogenesis, but how do adult tissues maintain their sexual identity? This study identifies a post-transcripti...
dx.plos.org
January 7, 2026 at 11:34 PM
Science conversations often chase buzzwords like cancer or disease-I once did too. Studying sex determination taught me that a “simple” basic question can reveal deep, far-reaching biology. Discovering Zelda’s role made it thrilling. Grateful to Erika Bach, colleagues, and my love for Drosophila.