Simon Davis
@sjdavis.bsky.social
Postdoc in Oxford working with spatial and single-cell proteomics
Reposted by Simon Davis
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...
www.biorxiv.org
July 27, 2025 at 12:28 PM
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Reposted by Simon Davis
Excited to introduce openDVP — an open-source framework to bring deep visual proteomics to the broader research community! It includes:
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
July 17, 2025 at 11:09 AM
Excited to introduce openDVP — an open-source framework to bring deep visual proteomics to the broader research community! It includes:
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
Reposted by Simon Davis
Our review is out now in Molecular & Cellular Proteomics! We discuss the latest advances in #HDX mass spectrometry to aid neurotherapeutic design & development in #Alzheimers, #Parkinsons and #ALS, providing molecular insights into protein aggregation pathways and therapeutic antibodies 🧠
Driving Therapeutic Innovation in Neurodegenerative Disease with Hydrogen Deuterium eXchange Mass Spectrometry
Human neurodegenerative conditions such as Parkinson’s and Alzheimer’s Disease are
characterized by the formation and deposition of toxic protein species which exacerbate
neuronal dysfunction, impacti...
www.mcponline.org
June 23, 2025 at 8:43 AM
Our review is out now in Molecular & Cellular Proteomics! We discuss the latest advances in #HDX mass spectrometry to aid neurotherapeutic design & development in #Alzheimers, #Parkinsons and #ALS, providing molecular insights into protein aggregation pathways and therapeutic antibodies 🧠
Reposted by Simon Davis
Victorian-era brains excavated in Bristol yield 1,200+ ancient proteins—reshaping how we study disease, memory & soft tissues in the past. A new frontier in bioarchaeology. #paleoproteomics #archaeology #ancientDNA #humanhistory
How Preserved Human Brains Are Rewriting Paleoproteomics
Decoding the Deep Past through Ancient Proteins
www.anthropology.net
May 29, 2025 at 5:29 PM
Victorian-era brains excavated in Bristol yield 1,200+ ancient proteins—reshaping how we study disease, memory & soft tissues in the past. A new frontier in bioarchaeology. #paleoproteomics #archaeology #ancientDNA #humanhistory
Reposted by Simon Davis
Deep palaeoproteomic profiling of archaeological human brains journals.plos.org/plosone/arti...
Deep palaeoproteomic profiling of archaeological human brains
Palaeoproteomics leverages the persistence, diversity, and biological import of ancient proteins to explore the past, and answer fundamental questions about phylogeny, environment, diet, and disease. ...
journals.plos.org
May 29, 2025 at 7:37 AM
Deep palaeoproteomic profiling of archaeological human brains journals.plos.org/plosone/arti...