John Calise
@sjcalise.bsky.social
Helen Hay Whitney Fellow in Justin Kollman's lab at the University of Washington. PhD '20 from University of Florida. I study cellular organization of nucleotide metabolism. Publications: https://scholar.google.com/citations?user=hJe-PLsAAAAJ&hl=en.
New preprint from the Kollman/Wills collab! My colleague Audrey O'Neill and friends demonstrate the effects of an IMPDH2 mutant associated with neurodevelopmental disorders on development using a Xenopus model. Beautiful electron and light microscopy included!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesis
IMP dehydrogenase (IMPDH) controls a key regulatory node in purine biosynthesis. Gain-of-function mutations in human IMPDH2 are associated with neurodevelopmental disorders and neuromuscular symptoms ...
www.biorxiv.org
May 12, 2025 at 5:11 PM
New preprint from the Kollman/Wills collab! My colleague Audrey O'Neill and friends demonstrate the effects of an IMPDH2 mutant associated with neurodevelopmental disorders on development using a Xenopus model. Beautiful electron and light microscopy included!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by John Calise
Deaths from heart disease down 75%, that’s NIH.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
April 28, 2025 at 5:20 PM
Deaths from heart disease down 75%, that’s NIH.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Reposted by John Calise
2023: mRNA vaccine scientists win the Nobel Prize
2025: US government cuts research on mRNA vaccines
2025: US government cuts research on mRNA vaccines
March 19, 2025 at 5:34 PM
2023: mRNA vaccine scientists win the Nobel Prize
2025: US government cuts research on mRNA vaccines
2025: US government cuts research on mRNA vaccines
Reposted by John Calise
Ardem, I am sorry. In this middle of this chaos, HHMI will always hold the dubious distinction of being the first organization, federal or private, to cut an ongoing and funded DEI program. In the darkest hour, it ran for the hills. As a member of those groups, I can’t tell you how painful this is.
Folks, let’s not be too quick to blame. HHMI is a progressive institution with strong leadership, doing what it can while navigating legal challenges. They get top legal advice on what’s possible, and these are tough times. Let’s not demonize one of the good ones!
Got a message today that HHMI remains deeply committed to the existing research programs that include the Investigator, Freeman Hrabowski Scholar, Hanna Gray Fellows, and Gilliam Fellow programs: "We do not anticipate changes to these or any other research or science education programs at HHMI."
February 7, 2025 at 8:36 PM
Ardem, I am sorry. In this middle of this chaos, HHMI will always hold the dubious distinction of being the first organization, federal or private, to cut an ongoing and funded DEI program. In the darkest hour, it ran for the hills. As a member of those groups, I can’t tell you how painful this is.
New Kollman lab preprint featuring some challenging cryo-EM by my colleague Kelli Hvorecny, in collaboration with the Klevit and Sokurenko labs: www.biorxiv.org/content/10.1...
#cryoEM #cryo-EM #microbiology #immunology
#cryoEM #cryo-EM #microbiology #immunology
Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference
A critical step in infections is the attachment of many microorganisms to host cells using lectins that bind surface glycans, making lectins promising antimicrobial targets. Upon binding mannosylated ...
www.biorxiv.org
January 5, 2025 at 7:48 PM
New Kollman lab preprint featuring some challenging cryo-EM by my colleague Kelli Hvorecny, in collaboration with the Klevit and Sokurenko labs: www.biorxiv.org/content/10.1...
#cryoEM #cryo-EM #microbiology #immunology
#cryoEM #cryo-EM #microbiology #immunology