Sanjeevi Sivasankar
@sivasankar-lab.bsky.social
Professor at University of California, Davis. Studying cadherins, desmosomes, biophysics of cell adhesion. Also developing new proximity labeling technologies.
https://sivasankarlab.ucdavis.edu/
https://sivasankarlab.ucdavis.edu/
The UC Davis Egghead blog has a very accessible story on our work.
Desmosomes are structures that stick cells together, especially in tissues under stress like hearth muscle. Scientists are uncovering how desmosomes can also transmit forces from the outside to the inside of a cell. @ucdavisengineering.bsky.social www.ucdavis.edu/blog/stretch...
A Stretchy Protein Senses Forces in Cells
How does skin hold you in? How do heart cells beat together? Researchers at the University of California, Davis, Department of Biomedical Engineering, are exploring how structures called desmosomes, w...
www.ucdavis.edu
October 10, 2025 at 11:39 PM
The UC Davis Egghead blog has a very accessible story on our work.
Delighted to announce the publication of our manuscript today in @natcomms.nature.com showing how desmosomes sense and respond to mechanical cytoskeletal forces. Led by the truly amazing Belle Dong with many thanks to our collaborators in the Choy & Kwiatkowski labs.
rdcu.be/eKpbL
rdcu.be/eKpbL
October 10, 2025 at 11:36 PM
Delighted to announce the publication of our manuscript today in @natcomms.nature.com showing how desmosomes sense and respond to mechanical cytoskeletal forces. Led by the truly amazing Belle Dong with many thanks to our collaborators in the Choy & Kwiatkowski labs.
rdcu.be/eKpbL
rdcu.be/eKpbL
UC Davis Egghead has a nice story on our latest research.
P-cadherin is overexpressed on malignant cancer cells, making it a target for antibody-directed therapy. Now biomedical engineers have a better understanding of how a P-cadherin/antibody complex gets slurped into a cell. www.ucdavis.edu/news/outside...
February 5, 2025 at 1:22 AM
UC Davis Egghead has a nice story on our latest research.
Delighted to announce our new publication in Nature Communications on outside-in engineering of cadherin endocytosis using a conformation strengthening antibody @naturecomms.bsky.social. Exceptional effort by co-first authors Bin Xie and Shipeng Xu. Funded by #NIH, #NIGMS.
rdcu.be/d7XKP
rdcu.be/d7XKP
Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody
Nature Communications - P-cadherins are cell adhesion proteins that are overexpressed in cancers. This study offers insights into the regulation of cell adhesion and the design of drug delivery...
rdcu.be
January 29, 2025 at 9:12 PM
Delighted to announce our new publication in Nature Communications on outside-in engineering of cadherin endocytosis using a conformation strengthening antibody @naturecomms.bsky.social. Exceptional effort by co-first authors Bin Xie and Shipeng Xu. Funded by #NIH, #NIGMS.
rdcu.be/d7XKP
rdcu.be/d7XKP
Announcing the publication of our paper in Structure describing the molecular mechanism by which antibodies strengthen the binding of E-cadherin cell-cell adhesion proteins. Fabulous work by Bin Xie and Shipeng Xu. Strong collaboration with Barry Gumbiner's lab.
doi.org/10.1016/j.st...
doi.org/10.1016/j.st...
December 7, 2023 at 9:30 PM
Announcing the publication of our paper in Structure describing the molecular mechanism by which antibodies strengthen the binding of E-cadherin cell-cell adhesion proteins. Fabulous work by Bin Xie and Shipeng Xu. Strong collaboration with Barry Gumbiner's lab.
doi.org/10.1016/j.st...
doi.org/10.1016/j.st...
This is a devastating loss to the field. Bill’s work in cell adhesion was an inspiration to so many labs. And Bill was a most generous and kind colleague. My deepest condolences to his family and friends.
I am sharing the sad news that we lost one of our colleagues, structural biologist, Bill Weis (Stanford); an amazing scientist and wonderful human being. Bill passed away October 13, 2023. RIP
October 21, 2023 at 9:26 PM
This is a devastating loss to the field. Bill’s work in cell adhesion was an inspiration to so many labs. And Bill was a most generous and kind colleague. My deepest condolences to his family and friends.
Delighted to announce publication of our light-activated proximity labeling technology for mapping protein–protein interactions at the cell membrane.
Special thanks to co-first authors Omer Shafraz and Carolyn Davis
Special thanks to co-first authors Omer Shafraz and Carolyn Davis
Light-activated BioID – an optically activated proximity labeling system to study protein–protei...
Summary: We present a light-activated proximity labeling technology for mapping protein–protein interactions at the cell membrane with high accuracy and precision.
doi.org
October 12, 2023 at 1:39 AM
Delighted to announce publication of our light-activated proximity labeling technology for mapping protein–protein interactions at the cell membrane.
Special thanks to co-first authors Omer Shafraz and Carolyn Davis
Special thanks to co-first authors Omer Shafraz and Carolyn Davis
Hi everyone
I am professor of Biomedical Engineering at the University of California, Davis. My group studies the biophysics of cell-cell adhesion. We also develop new technologies to map adhesive protein interactions in cells. 🔬
#HiSciSky
I am professor of Biomedical Engineering at the University of California, Davis. My group studies the biophysics of cell-cell adhesion. We also develop new technologies to map adhesive protein interactions in cells. 🔬
#HiSciSky
September 23, 2023 at 7:22 PM
Hi everyone
I am professor of Biomedical Engineering at the University of California, Davis. My group studies the biophysics of cell-cell adhesion. We also develop new technologies to map adhesive protein interactions in cells. 🔬
#HiSciSky
I am professor of Biomedical Engineering at the University of California, Davis. My group studies the biophysics of cell-cell adhesion. We also develop new technologies to map adhesive protein interactions in cells. 🔬
#HiSciSky