@sivanleuven.bsky.social
Consultant rheumatologist at the Radboudumc with a special interest in cardio-rheumatology and Systemic Lupus Erythematosus
Reposted
Metanalysis of cardiovascular death in syst immune-mediated Dz (SIDs): 39 studies, 171,748 pts - SIDs assoc w/ signif. higher CV mortality (HR 1.26; 1.09-1.47; p = 0.002), especially for RA, SLE, GPA & females. 92% of CV deaths from acute coronary syndrome (ACS) pmc.ncbi.nlm.nih.gov/articles/PMC...
The risk of cardiovascular death in systemic immune-mediated diseases: A systematic review and meta-analysis
To perform a systematic review and meta-analysis assessing the association between systemic immune-mediated diseases (SIDs) and cardiovascular death. A systematic search of PubMed, Cochrane Library,…
pmc.ncbi.nlm.nih.gov
January 15, 2026 at 3:03 PM
Metanalysis of cardiovascular death in syst immune-mediated Dz (SIDs): 39 studies, 171,748 pts - SIDs assoc w/ signif. higher CV mortality (HR 1.26; 1.09-1.47; p = 0.002), especially for RA, SLE, GPA & females. 92% of CV deaths from acute coronary syndrome (ACS) pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted
🧠 Brain fog in lupus is real, but its meaning has never been clearly defined in a lupus-specific way.
🙏 Help us & the research team led by Prof Laurent Arnaud validate the Lupus Brain Fog Severity Scale (LBFSS).
Your input is essential.
https://lupusresearch.limequery.org/337533?lang=en
🙏 Help us & the research team led by Prof Laurent Arnaud validate the Lupus Brain Fog Severity Scale (LBFSS).
Your input is essential.
https://lupusresearch.limequery.org/337533?lang=en
January 8, 2026 at 4:04 PM
🧠 Brain fog in lupus is real, but its meaning has never been clearly defined in a lupus-specific way.
🙏 Help us & the research team led by Prof Laurent Arnaud validate the Lupus Brain Fog Severity Scale (LBFSS).
Your input is essential.
https://lupusresearch.limequery.org/337533?lang=en
🙏 Help us & the research team led by Prof Laurent Arnaud validate the Lupus Brain Fog Severity Scale (LBFSS).
Your input is essential.
https://lupusresearch.limequery.org/337533?lang=en
International development and validation of a multilingual bank of items for the self-assessment of essential knowledge by systemic lupus erythematosus patients: the SLE Knowledge Assessment score (SLAKE) url: academic.oup.com/rheumatology...
International development and validation of a multilingual bank of items for the self-assessment of essential knowledge by systemic lupus erythematosus patients: the SLE Knowledge Assessment score (SL...
AbstractObjectives. Patient education is increasingly acknowledged as an important aspect of the management of systemic lupus erythematosus (SLE). The aim
academic.oup.com
January 5, 2026 at 5:30 PM
International development and validation of a multilingual bank of items for the self-assessment of essential knowledge by systemic lupus erythematosus patients: the SLE Knowledge Assessment score (SLAKE) url: academic.oup.com/rheumatology...
Magnificent overview by dr Weber at
#LupusAcademy2025 on diverse manifestations of CV disease in #Lupus, including athersclerosis, pericarditis, heart failure and microvascular dysfunction. Multimodality imaging can improve screening, detection and monitoring of cardiac function. #cardiorheum
#LupusAcademy2025 on diverse manifestations of CV disease in #Lupus, including athersclerosis, pericarditis, heart failure and microvascular dysfunction. Multimodality imaging can improve screening, detection and monitoring of cardiac function. #cardiorheum
October 9, 2025 at 2:51 PM
Magnificent overview by dr Weber at
#LupusAcademy2025 on diverse manifestations of CV disease in #Lupus, including athersclerosis, pericarditis, heart failure and microvascular dysfunction. Multimodality imaging can improve screening, detection and monitoring of cardiac function. #cardiorheum
#LupusAcademy2025 on diverse manifestations of CV disease in #Lupus, including athersclerosis, pericarditis, heart failure and microvascular dysfunction. Multimodality imaging can improve screening, detection and monitoring of cardiac function. #cardiorheum
Interesting study in @ahajournals.bsky.social
showing higher risk of aortic stenosis, aortic regurgitation, and mitral regurgitation in #rheumatoidarthritis. Women and younger patients exhibiting higher risks. Similar findings reported in #lupus and #scleroderma. #cardiorheum
ahajrnls.org/4fVia1A
showing higher risk of aortic stenosis, aortic regurgitation, and mitral regurgitation in #rheumatoidarthritis. Women and younger patients exhibiting higher risks. Similar findings reported in #lupus and #scleroderma. #cardiorheum
ahajrnls.org/4fVia1A
Association Between Rheumatoid Arthritis and the Risk of Incident Degenerative Valvular Heart Disease: Evidence From a Prospective Cohort Study | Journal of the American Heart Association
ahajrnls.org
September 4, 2025 at 11:36 AM
Interesting study in @ahajournals.bsky.social
showing higher risk of aortic stenosis, aortic regurgitation, and mitral regurgitation in #rheumatoidarthritis. Women and younger patients exhibiting higher risks. Similar findings reported in #lupus and #scleroderma. #cardiorheum
ahajrnls.org/4fVia1A
showing higher risk of aortic stenosis, aortic regurgitation, and mitral regurgitation in #rheumatoidarthritis. Women and younger patients exhibiting higher risks. Similar findings reported in #lupus and #scleroderma. #cardiorheum
ahajrnls.org/4fVia1A
In our latest publication we highlight #atherosclerosis is already enhanced before the actual SLE diagnosis (diagnostic delay). Moreover #cardiovascular disease in #lupus is associated with an adverse outcome (including recurrent events and mortality). #cardiorheum
academic.oup.com/rheumap/arti...
academic.oup.com/rheumap/arti...
Atherosclerotic cardiovascular disease in systemic lupus erythematosus: from preclinical lupus to atherosclerotic plaque erosion
Abstract. Patients with systemic lupus erythematosus (SLE) have increased risk of developing atherosclerotic cardiovascular disease (ASCVD). This excessive
academic.oup.com
July 29, 2025 at 11:29 AM
In our latest publication we highlight #atherosclerosis is already enhanced before the actual SLE diagnosis (diagnostic delay). Moreover #cardiovascular disease in #lupus is associated with an adverse outcome (including recurrent events and mortality). #cardiorheum
academic.oup.com/rheumap/arti...
academic.oup.com/rheumap/arti...
In addition to hydroxychloroquine dose and duration of use, increasing age, female sex and kidney disease are associated with a higher risk of hydroxychloroquine retinopathy in #lupus patients.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Hydroxychloroquine Retinal Toxicity | NEJM
A 71-year-old woman with systemic lupus erythematosus presented to the ophthalmology
clinic for an annual screening examination for hydroxychloroquine-related toxic effects.
She reported no vision ...
www.nejm.org
July 28, 2025 at 8:44 AM
In addition to hydroxychloroquine dose and duration of use, increasing age, female sex and kidney disease are associated with a higher risk of hydroxychloroquine retinopathy in #lupus patients.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
The median time from onset of #lupus symptoms or disease signs to a formal SLE diagnosis is an estimated 9 to 78 months! Such major diagnostic delay frequently leads to irreversible organ damage. A unified definition of diagnostic delay and identifying barriers are crucial.
July 27, 2025 at 8:09 PM
The median time from onset of #lupus symptoms or disease signs to a formal SLE diagnosis is an estimated 9 to 78 months! Such major diagnostic delay frequently leads to irreversible organ damage. A unified definition of diagnostic delay and identifying barriers are crucial.
Reposted
#lupus When lupus nephritis hits, but so does @glaucomflecken.bsky.social latest reel 😁
'Call the code Lupus' ⚡🔵
youtu.be/HMkZIpnNbr4?...
'Call the code Lupus' ⚡🔵
youtu.be/HMkZIpnNbr4?...
Dr. Glaucomflecken Explains: Obinutuzumab in Lupus Nephritis (REGENCY)
YouTube video by NEJM Group
youtu.be
July 5, 2025 at 2:19 PM
#lupus When lupus nephritis hits, but so does @glaucomflecken.bsky.social latest reel 😁
'Call the code Lupus' ⚡🔵
youtu.be/HMkZIpnNbr4?...
'Call the code Lupus' ⚡🔵
youtu.be/HMkZIpnNbr4?...
#Pericarditis has a high recurrence rate in #Lupus (20%), especially in younger patients (<40yrs). Use of prednisone >20mg is associated with a high recurrence rate, in a dose-dependent matter. Yet another reason to limit GC exposure. #EULAR2025 #CardioRheum
June 13, 2025 at 12:17 PM
#Pericarditis has a high recurrence rate in #Lupus (20%), especially in younger patients (<40yrs). Use of prednisone >20mg is associated with a high recurrence rate, in a dose-dependent matter. Yet another reason to limit GC exposure. #EULAR2025 #CardioRheum
Magnificent session on the rigorous process to formulate recommendations for challenging manifestations in #Lupus at #EULAR25. #rheumatology #rheumsky
June 13, 2025 at 11:58 AM
Magnificent session on the rigorous process to formulate recommendations for challenging manifestations in #Lupus at #EULAR25. #rheumatology #rheumsky
Very excited to discuss #atherosclerosis and #cardiovascular disease in #Rheumatology at #EULAR2025. Patients with #Lupus and #rheumatoidarthritis may be prone to develop plaque erosion. #CardioRheum #Rheumsky
June 12, 2025 at 3:16 PM
Very excited to discuss #atherosclerosis and #cardiovascular disease in #Rheumatology at #EULAR2025. Patients with #Lupus and #rheumatoidarthritis may be prone to develop plaque erosion. #CardioRheum #Rheumsky
Very interesting Hot topics in cardio-rheumatology session at #EULAR2025 with prof. Nurmohamed, Atzeni and Alunno. Risk management guidelines are available, implementation stays behind. Discussed strategies to improve this. #CardioRheum #Lupus #rheumatoidarthritis
June 12, 2025 at 3:02 PM
Very interesting Hot topics in cardio-rheumatology session at #EULAR2025 with prof. Nurmohamed, Atzeni and Alunno. Risk management guidelines are available, implementation stays behind. Discussed strategies to improve this. #CardioRheum #Lupus #rheumatoidarthritis
Great first day at #EULAR2025 by @eular.org. Very excited to discuss our data on the perspective of patients and rheumatologists on cardiovascular risk management. #rheumatoidarthritis #Lupus #rheumsky #rheumatology
June 11, 2025 at 4:02 PM
Great first day at #EULAR2025 by @eular.org. Very excited to discuss our data on the perspective of patients and rheumatologists on cardiovascular risk management. #rheumatoidarthritis #Lupus #rheumsky #rheumatology
Full house and really impressive results with CAR-T cell therapy in now 27 patients with refractory #Lupus (92% remission). Hopefully these extraordinary results can be reproduced in a larger trial. #EULAR2025 #Rheumatology #Rheumsky
June 11, 2025 at 12:38 PM
Full house and really impressive results with CAR-T cell therapy in now 27 patients with refractory #Lupus (92% remission). Hopefully these extraordinary results can be reproduced in a larger trial. #EULAR2025 #Rheumatology #Rheumsky
Judging by the amazing view from the roof of our hotel it looks like a great day to get #EULAR2025 going! #Rheumatology #Rheumsky
June 11, 2025 at 5:55 AM
Judging by the amazing view from the roof of our hotel it looks like a great day to get #EULAR2025 going! #Rheumatology #Rheumsky
Great study in @ACR-journals.bsky.social. Meeting targets of traditional risk factors (e.g. #cholesterol, BP) and remission of #SLE activity significantly attenutate the increased risk of #atherosclerosis in #Lupus during 10 year followup!
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Atherosclerotic Plaque Progression and Incident Cardiovascular Events in a 10‐Year Prospective Study of Patients With Systemic Lupus Erythematosus: The Impact of Persistent Cardiovascular Risk Factor Target Attainment and Sustained DORIS Remission
Objective Cardiovascular disease (CVD) is a leading cause of death in individuals with systemic lupus erythematosus (SLE). We assessed atherosclerotic plaque progression and incident cardiovascular ...
acrjournals.onlinelibrary.wiley.com
June 2, 2025 at 10:11 AM
Great study in @ACR-journals.bsky.social. Meeting targets of traditional risk factors (e.g. #cholesterol, BP) and remission of #SLE activity significantly attenutate the increased risk of #atherosclerosis in #Lupus during 10 year followup!
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...