Singleron Biotechnologies
@singleronbio.bsky.social
From single cell multi-omics to precision medicine
MIRO1 and #Parkinson’s: #singlecell #RNAseq and metabolic modeling of #organoids linked MIRO1 p.R272Q mutation to metabolic deficits and disrupted neuron-astrocyte metabolic crosstalk. Singleron GEXSCOPE kit used.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss - npj Systems Biology and Applications
npj Systems Biology and Applications - MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss
www.nature.com
April 21, 2025 at 3:32 PM
MIRO1 and #Parkinson’s: #singlecell #RNAseq and metabolic modeling of #organoids linked MIRO1 p.R272Q mutation to metabolic deficits and disrupted neuron-astrocyte metabolic crosstalk. Singleron GEXSCOPE kit used.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cost-effective, high throughput #RNAseq solution designed for:
#DrugScreen
#PopulationGenetics
#corefacilty
….and much more!
#DrugScreen
#PopulationGenetics
#corefacilty
….and much more!
Singleron AccuraCode®: Cost-effective, High-Throughput mRNA sequencing for Drug Discovery
YouTube video by Singleron Biotechnologies
youtu.be
April 9, 2025 at 11:18 PM
Cost-effective, high throughput #RNAseq solution designed for:
#DrugScreen
#PopulationGenetics
#corefacilty
….and much more!
#DrugScreen
#PopulationGenetics
#corefacilty
….and much more!
Interested in a high-throughput, cost effective #RNAseq method for #drugscreening? Join our webinar this Thursday!
March 31, 2025 at 12:15 PM
Interested in a high-throughput, cost effective #RNAseq method for #drugscreening? Join our webinar this Thursday!
Come and meet us at the 4th #singlecell and Spatial Omics Symposium on April 10-11th in Baltimore!
March 27, 2025 at 3:48 PM
Come and meet us at the 4th #singlecell and Spatial Omics Symposium on April 10-11th in Baltimore!
Singleron Bio Expands Global Footprint, Ups Single-Cell Throughput With Eye Toward Clinical Apps- thanks GenomeWeb for this nice Report on our recent progress!
Singleron Bio Expands Global Footprint, Ups Single-Cell Throughput With Eye Toward Clinical Apps
The single-cell technology company, which previously focused on China and Europe, is hoping to expand into the US and the Middle East markets.
www.genomeweb.com
March 25, 2025 at 1:57 PM
Singleron Bio Expands Global Footprint, Ups Single-Cell Throughput With Eye Toward Clinical Apps- thanks GenomeWeb for this nice Report on our recent progress!
Unleash the Full Story of Each Single Cell! Join us for a webinar on the first high throughput, full length, single cell RNAseq product!
March 20, 2025 at 3:28 PM
Unleash the Full Story of Each Single Cell! Join us for a webinar on the first high throughput, full length, single cell RNAseq product!
A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations: Singleron GEXSCOPE Single Yeast Kit used in this exciting study.
A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations - Nature Communications
Heterogeneity determines cell fate and phenotypic variability, but its molecular mechanisms are not well understood. Here the authors present a high-resolution single-cell yeast transcriptome atlas of...
www.nature.com
March 18, 2025 at 8:58 PM
A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations: Singleron GEXSCOPE Single Yeast Kit used in this exciting study.
Turns out, the old saying is true—your gut really does rule your world! This interesting study shows that social rank shapes gut microbes, which in turn influence brain function and behavior. Singleron Single Nucleus RNAseq kit used.
Perturbations in the microbiota-gut-brain axis shaped by social status loss - Communications Biology
The PI3K-Akt signaling pathway of the microbiotagut-brain axis is involved in forced loss induced by forced reduction of social rank in mice, and influences the outcome of forced loss.
www.nature.com
March 17, 2025 at 10:26 PM
Turns out, the old saying is true—your gut really does rule your world! This interesting study shows that social rank shapes gut microbes, which in turn influence brain function and behavior. Singleron Single Nucleus RNAseq kit used.
Want to have a #tissue processing machine that addresses most of #molecular and #cell biology needs in lab such as generating #singlecell suspension , nuclei extraction, homogenization? With style and efficiency? Check out our new PythoNi!
March 12, 2025 at 12:38 PM
Want to have a #tissue processing machine that addresses most of #molecular and #cell biology needs in lab such as generating #singlecell suspension , nuclei extraction, homogenization? With style and efficiency? Check out our new PythoNi!
#singlecell analysis helps to reveal mechanisms of #rarediseases- and find effective therapies. Watch an interview on German TV with our collaborator in B2B-RARE Consortium, a project sponsored by German State of NRW to use #omics +AI to help patients.
Lokalzeit aus Düsseldorf | 28.02.2025 - hier anschauen
Die Lokalzeit aus Düsseldorf ist das regionale Magazin im WDR Fernsehen für den Großraum Düsseldorf.
www.ardmediathek.de
March 10, 2025 at 2:52 PM
#singlecell analysis helps to reveal mechanisms of #rarediseases- and find effective therapies. Watch an interview on German TV with our collaborator in B2B-RARE Consortium, a project sponsored by German State of NRW to use #omics +AI to help patients.
Wishing a stellar International Women's Day to the rockstar women in life sciences! You’re decoding genes, deciphering cells, and healing the world with cutting-edge medicine—keep breaking the science ceiling! 🎉🔬💊 #InternationalWomensDay #WomenInLifeScience #ScienceQueens
March 8, 2025 at 12:52 PM
Wishing a stellar International Women's Day to the rockstar women in life sciences! You’re decoding genes, deciphering cells, and healing the world with cutting-edge medicine—keep breaking the science ceiling! 🎉🔬💊 #InternationalWomensDay #WomenInLifeScience #ScienceQueens
A Mayo Clinic study shows that preoperative #MRA associated with 40% reduction in POAF/41% lower AF. #snRNA using Singleron product suggests that canrenone added to cardiac preservation solution inhibits pahways related to chronic AF.
www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post-Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest
Background New postoperative atrial fibrillation (POAF) occurs in about 40% after cardiac surgery. Mineralocorticoid receptor antagonists (MRA) are known to reduce chronic atrial fibrillation (AF) dev...
www.biorxiv.org
March 6, 2025 at 1:36 PM
A Mayo Clinic study shows that preoperative #MRA associated with 40% reduction in POAF/41% lower AF. #snRNA using Singleron product suggests that canrenone added to cardiac preservation solution inhibits pahways related to chronic AF.
www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
Intracellular #bacteria could play a role in the pathology and progression of various #diseases. Our new FocuSCOPE 16s kit detects host cell transcriptome AND intercellular bacteria #16S from same #singlecells. Contact us at info@singleron.bio to find out more!
March 3, 2025 at 5:36 PM
Intracellular #bacteria could play a role in the pathology and progression of various #diseases. Our new FocuSCOPE 16s kit detects host cell transcriptome AND intercellular bacteria #16S from same #singlecells. Contact us at info@singleron.bio to find out more!
Kölle Alaaf!
Carnival in our office in Cologne, Germany 🥳
Carnival in our office in Cologne, Germany 🥳
February 28, 2025 at 9:02 PM
Kölle Alaaf!
Carnival in our office in Cologne, Germany 🥳
Carnival in our office in Cologne, Germany 🥳
Parkinson's disease studied with #singlecell sequencing + #organoids.
Singleron GEXSCOPE Single Cell RNA Library Kit used.
academic.oup.com/brain/advanc...
Singleron GEXSCOPE Single Cell RNA Library Kit used.
academic.oup.com/brain/advanc...
Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss
Mutations in the gene encoding Miro1, a mitochondrial GTPase, have been identified in patients with Parkinson’s disease. Using neuronal cell cultures and m
academic.oup.com
February 11, 2025 at 4:11 PM
Parkinson's disease studied with #singlecell sequencing + #organoids.
Singleron GEXSCOPE Single Cell RNA Library Kit used.
academic.oup.com/brain/advanc...
Singleron GEXSCOPE Single Cell RNA Library Kit used.
academic.oup.com/brain/advanc...
Another great example on how #AI in combination with #Singlecell techniques can discover biological insights with unprecedented speed and depth
Generative AI Model, ChromoGen, Rapidly Predicts Single-Cell Chromatin Conformations
New AI model takes minutes rather than days to predict how a specific DNA sequence will arrange itself in the cell nucleus.
www.genengnews.com
February 9, 2025 at 6:32 PM
Another great example on how #AI in combination with #Singlecell techniques can discover biological insights with unprecedented speed and depth
Improved method to detect nascent RNA at single cell resolution, developed by Singleron scientist + collaborators
pubmed.ncbi.nlm.nih.gov/39908452/
pubmed.ncbi.nlm.nih.gov/39908452/
In Vivo Time-Resolved Single-Cell RNA-Seq Reveals Chemotherapy-Induced Transcriptional Dynamics in Tumor Infiltrating Lymphocytes - PubMed
Single-cell RNA sequencing (scRNA-seq) using metabolic RNA labeling enables detailed analysis of dynamic gene expression within single cells. However, most studies are limited to in vitro settings, re...
pubmed.ncbi.nlm.nih.gov
February 6, 2025 at 1:48 PM
Improved method to detect nascent RNA at single cell resolution, developed by Singleron scientist + collaborators
pubmed.ncbi.nlm.nih.gov/39908452/
pubmed.ncbi.nlm.nih.gov/39908452/
Initiate Analysis in CeleLens™ Cloud
YouTube video by Singleron Biotechnologies
m.youtube.com
February 5, 2025 at 10:13 AM
We are getting ready to present our new #singlecell #automation platform Tensor Festival of Genomics in London! Come join us at 4pm this afternoon for the product presentation!
January 29, 2025 at 9:40 AM
We are getting ready to present our new #singlecell #automation platform Tensor Festival of Genomics in London! Come join us at 4pm this afternoon for the product presentation!
Immune evasion through mitochondrial transfer in the tumour #microenvironment : intriguing cellular interactions in cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 26, 2025 at 3:55 AM
Immune evasion through mitochondrial transfer in the tumour #microenvironment : intriguing cellular interactions in cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Tensor: Single Cell Sequencing End-to-End Automation, from cells to sequencing - ready libraries . Visit our homepage or contact us to find out more!
Tensor | Single Cell Sequencing End-to-End Automation
Singleron introduces Tensor, the first instrument for full single cell RNA-seq automation,from cell suspension to sequencing-ready library.
singleron.bio
January 22, 2025 at 10:38 PM
Tensor: Single Cell Sequencing End-to-End Automation, from cells to sequencing - ready libraries . Visit our homepage or contact us to find out more!
Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular #lymphoma - and #singlecell sequencing helped to understand how. Singleron GEXSCOPE used in this clinical study.
Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma
www.nature.com
January 21, 2025 at 8:53 AM
Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular #lymphoma - and #singlecell sequencing helped to understand how. Singleron GEXSCOPE used in this clinical study.
#Single-nuclei #RNAseq to revealed auxin-driven mechanisms of wood plasticity and severe drought tolerance in poplar. Singleron GEXSCOPE used for this #plant study.
Single-nuclei transcriptomics revealed auxin-driven mechanisms of wood plasticity and severe drought tolerance in poplar
Drought significantly affects forests and woody crops by limiting their growth, increasing their susceptibility to diseases, and reducing productivity. Wood anatomical plasticity is a crucial adaptive...
www.biorxiv.org
January 14, 2025 at 1:16 AM
#Single-nuclei #RNAseq to revealed auxin-driven mechanisms of wood plasticity and severe drought tolerance in poplar. Singleron GEXSCOPE used for this #plant study.
Recent #singlecell models enable deeper insights into the ever growing wealth of data. Recently published GET is a generalizable and accurate model for transcription, gene regulation and transcription factor interactions, all with cell type specificity.
A foundation model of transcription across human cell types - Nature
A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...
www.nature.com
January 12, 2025 at 11:29 PM
Recent #singlecell models enable deeper insights into the ever growing wealth of data. Recently published GET is a generalizable and accurate model for transcription, gene regulation and transcription factor interactions, all with cell type specificity.