Simon Schultz
@simonschultz.bsky.social
Australian expat neuron wrangler. Prof of Neurotechnology at Imperial College London. Investigates memory and cognition with photons. Runs and rides bikes a lot. Stray sheep.
We demonstrate the use of three-photon microscopy to track changes in vascular structure related to amyloid plaque formation in the APP NL-G-F knock-in model of Alzheimer's Disease.
August 16, 2025 at 9:59 PM
We demonstrate the use of three-photon microscopy to track changes in vascular structure related to amyloid plaque formation in the APP NL-G-F knock-in model of Alzheimer's Disease.
New preprint from the lab. Eline Stas et al, "Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer's disease".
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 16, 2025 at 9:55 PM
New preprint from the lab. Eline Stas et al, "Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer's disease".
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
There is a beautiful movie but Bluesky won't show it bc of the aspect ratio, so instead I just show the first frame above. However, here is another snippet - this time simultaneous imaging of 4 different cortical regions at a depth of 520 µm at 7 Hz. All in head-fixed mice exploring a 2D chamber.
June 11, 2025 at 9:34 PM
There is a beautiful movie but Bluesky won't show it bc of the aspect ratio, so instead I just show the first frame above. However, here is another snippet - this time simultaneous imaging of 4 different cortical regions at a depth of 520 µm at 7 Hz. All in head-fixed mice exploring a 2D chamber.