Simon Schultz
@simonschultz.bsky.social
Australian expat neuron wrangler. Prof of Neurotechnology at Imperial College London. Investigates memory and cognition with photons. Runs and rides bikes a lot. Stray sheep.
Nice. Here’s my little harvest of the morning.
September 20, 2025 at 12:59 PM
Nice. Here’s my little harvest of the morning.
We demonstrate the use of three-photon microscopy to track changes in vascular structure related to amyloid plaque formation in the APP NL-G-F knock-in model of Alzheimer's Disease.
August 16, 2025 at 9:59 PM
We demonstrate the use of three-photon microscopy to track changes in vascular structure related to amyloid plaque formation in the APP NL-G-F knock-in model of Alzheimer's Disease.
New preprint from the lab. Eline Stas et al, "Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer's disease".
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 16, 2025 at 9:55 PM
New preprint from the lab. Eline Stas et al, "Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer's disease".
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The second of the hippocampus-inspired paintings by @anjiolina.bsky.social just came back from framing. I’m very happy with how it turned out.
June 15, 2025 at 1:58 PM
The second of the hippocampus-inspired paintings by @anjiolina.bsky.social just came back from framing. I’m very happy with how it turned out.
There is a beautiful movie but Bluesky won't show it bc of the aspect ratio, so instead I just show the first frame above. However, here is another snippet - this time simultaneous imaging of 4 different cortical regions at a depth of 520 µm at 7 Hz. All in head-fixed mice exploring a 2D chamber.
June 11, 2025 at 9:34 PM
There is a beautiful movie but Bluesky won't show it bc of the aspect ratio, so instead I just show the first frame above. However, here is another snippet - this time simultaneous imaging of 4 different cortical regions at a depth of 520 µm at 7 Hz. All in head-fixed mice exploring a 2D chamber.
This paper presents ULTRA, a new microscope platform which can image a field of view over 7mm diameter and at depths up to 900 µm into cortex. We can image ~10,000 neurons simultaneously at high SNR, and at the same time have the spatial resolution to capture dendritic spines. 1 frame of a movie:
June 11, 2025 at 9:29 PM
This paper presents ULTRA, a new microscope platform which can image a field of view over 7mm diameter and at depths up to 900 µm into cortex. We can image ~10,000 neurons simultaneously at high SNR, and at the same time have the spatial resolution to capture dendritic spines. 1 frame of a movie:
This is the other hippocampal painting by @anjiolina.bsky.social - I am taking it down to have it framed now. I really like this one.
(As I mentioned before, she does neuro-inspired artworks on commission; if you are interested, contact her directly here or via instagram @neuronakaya).
(As I mentioned before, she does neuro-inspired artworks on commission; if you are interested, contact her directly here or via instagram @neuronakaya).
May 24, 2025 at 1:26 PM
This is the other hippocampal painting by @anjiolina.bsky.social - I am taking it down to have it framed now. I really like this one.
(As I mentioned before, she does neuro-inspired artworks on commission; if you are interested, contact her directly here or via instagram @neuronakaya).
(As I mentioned before, she does neuro-inspired artworks on commission; if you are interested, contact her directly here or via instagram @neuronakaya).
We need to start them on it younger.
May 16, 2025 at 1:49 PM
We need to start them on it younger.
You may try to escape, Mr Snowy, but you won’t get far.
February 27, 2025 at 11:54 AM
You may try to escape, Mr Snowy, but you won’t get far.
Andreas Horn speaking now
February 25, 2025 at 2:26 AM
Andreas Horn speaking now
Love the BrainBox t-shirt
ブレインボックス
ブレインボックス
February 25, 2025 at 2:03 AM
Love the BrainBox t-shirt
ブレインボックス
ブレインボックス
I want to thank especially first author Yimei Li for the huge amount of work she carried out over the 4 years of her PhD (including the pandemic), establishing a head-fixed spatial working memory task that can be used with 2P imaging. She was a truly wonderful student, and a great scientist.
February 7, 2025 at 5:54 PM
I want to thank especially first author Yimei Li for the huge amount of work she carried out over the 4 years of her PhD (including the pandemic), establishing a head-fixed spatial working memory task that can be used with 2P imaging. She was a truly wonderful student, and a great scientist.
We trained head-fixed mice on a fig-8 spatial alternation task. Learning performance was sensitive to age and genototype, with 5xFAD mice showing impairment. Spatial coding and place cell stability disruptions preceded behav. deficits. Splitter cell degradation correlated with poor task performance.
February 7, 2025 at 11:21 AM
We trained head-fixed mice on a fig-8 spatial alternation task. Learning performance was sensitive to age and genototype, with 5xFAD mice showing impairment. Spatial coding and place cell stability disruptions preceded behav. deficits. Splitter cell degradation correlated with poor task performance.
@nicolecrust.bsky.social I randomly came across this photo of you at my wedding... some time ago now.
February 1, 2025 at 4:55 PM
@nicolecrust.bsky.social I randomly came across this photo of you at my wedding... some time ago now.
Hippocampus inspired painting by artist Anjiolina Nakaya @anjiolina.bsky.social. I understand that she takes commissions, and is painting to raise money to pay her way through uni. #neuroart
January 12, 2025 at 1:35 PM
Hippocampus inspired painting by artist Anjiolina Nakaya @anjiolina.bsky.social. I understand that she takes commissions, and is painting to raise money to pay her way through uni. #neuroart
Happy New Year! 🎉🥳
December 31, 2024 at 11:28 AM
Happy New Year! 🎉🥳
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 20.
#Books
#BookSky
#BookChallenge
Day 20.
December 23, 2024 at 12:33 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 20.
#Books
#BookSky
#BookChallenge
Day 20.
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 19.
#Books
#BookSky
#BookChallenge
Day 19.
December 22, 2024 at 9:08 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 19.
#Books
#BookSky
#BookChallenge
Day 19.
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 18.
#Books
#BookSky
#BookChallenge
Day 18.
December 19, 2024 at 4:01 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 18.
#Books
#BookSky
#BookChallenge
Day 18.
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 17.
#Books
#BookSky
#BookChallenge
Day 17.
December 18, 2024 at 5:07 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books
#BookSky
#BookChallenge
Day 17.
#Books
#BookSky
#BookChallenge
Day 17.