Simon Richardson
@simonrichardson.bsky.social
Clinician Scientist and Consultant Haematologist | Researches stem cell biology, epigenetics and drug discovery, specialising in B-ALL | Fellow St Catharine's College, Cambridge
On my way back from a fabulous day of science and catching up with friends and colleagues at the UKALL Research Network update day. Great to see so much progress. 👍
October 10, 2025 at 6:34 PM
On my way back from a fabulous day of science and catching up with friends and colleagues at the UKALL Research Network update day. Great to see so much progress. 👍
Thank you @leukaemiauk.bsky.social for the invitation to #WCD2025. 😋 It was great to share some of our work and humbling to hear the story of 4 year old Billie the Brave. Congrats on raising so much in one evening for life changing leukaemia research! ❤️
September 16, 2025 at 3:21 PM
Thank you @leukaemiauk.bsky.social for the invitation to #WCD2025. 😋 It was great to share some of our work and humbling to hear the story of 4 year old Billie the Brave. Congrats on raising so much in one evening for life changing leukaemia research! ❤️
No trains? No problem! Wacky races down to The City of London with these amazing @crukcamcentre.bsky.social entrepreneurial scientists just in time for the CRUK Innovation and Enterprise awards. Thank you @crhorizons.bsky.social 🥂🎉🙏
July 11, 2025 at 10:00 PM
No trains? No problem! Wacky races down to The City of London with these amazing @crukcamcentre.bsky.social entrepreneurial scientists just in time for the CRUK Innovation and Enterprise awards. Thank you @crhorizons.bsky.social 🥂🎉🙏
Absolute honour to attend Marc Mansour’s @marcmansour.bsky.social inaugural lecture at ICH today. An inspiring clinician scientist and all round legend. #researchculture
July 9, 2025 at 10:59 PM
Absolute honour to attend Marc Mansour’s @marcmansour.bsky.social inaugural lecture at ICH today. An inspiring clinician scientist and all round legend. #researchculture
Really exciting to co-organise the 20 year graduation reunion for Oxford medical school last night. Wonderful to reunite with old friends and hear retired DoS Tim Lancaster speak powerfully about how caring is at the heart of good medicine 💊❤️
July 6, 2025 at 8:00 AM
Really exciting to co-organise the 20 year graduation reunion for Oxford medical school last night. Wonderful to reunite with old friends and hear retired DoS Tim Lancaster speak powerfully about how caring is at the heart of good medicine 💊❤️
What an inspiring evening hearing from patients, researchers and fundraisers at an Evening with Leukaemia UK.
So much progress. So much to do
@leukaemiauk.bsky.social
So much progress. So much to do
@leukaemiauk.bsky.social
June 9, 2025 at 10:46 PM
What an inspiring evening hearing from patients, researchers and fundraisers at an Evening with Leukaemia UK.
So much progress. So much to do
@leukaemiauk.bsky.social
So much progress. So much to do
@leukaemiauk.bsky.social
And that’s a wrap. 20 supervisons in biochemistry and genetics for the Catz @stcatharines.bsky.social first year medics. Good luck in the exams!
May 22, 2025 at 3:49 PM
And that’s a wrap. 20 supervisons in biochemistry and genetics for the Catz @stcatharines.bsky.social first year medics. Good luck in the exams!
9/12 The results almost perfectly replicated the findings in our genetic model, confirming marked sensitisation or synergy between CREBBP and BCL2 inhibitors in cell line and PDX models in vitro and in vivo.
May 20, 2025 at 9:43 AM
9/12 The results almost perfectly replicated the findings in our genetic model, confirming marked sensitisation or synergy between CREBBP and BCL2 inhibitors in cell line and PDX models in vitro and in vivo.
7/12 Interestingly, these changes can also be seen in patients – TARGET RNAseq data showed that low expression of CREBBP strongly correlates with dysregulation of ether-linked lipid pathways and up-regulation of redox scavengers.
May 20, 2025 at 9:42 AM
7/12 Interestingly, these changes can also be seen in patients – TARGET RNAseq data showed that low expression of CREBBP strongly correlates with dysregulation of ether-linked lipid pathways and up-regulation of redox scavengers.
4/12 Targeted drug screening on these lines showed that CREBBP mutations potently sensitised the B-ALL cell lines to the BCL2 inhibitor Venetoclax, with up to a 1000x change in lethal dose.
May 20, 2025 at 9:39 AM
4/12 Targeted drug screening on these lines showed that CREBBP mutations potently sensitised the B-ALL cell lines to the BCL2 inhibitor Venetoclax, with up to a 1000x change in lethal dose.
