Simon McGrath
@simonmcg.bsky.social
I occasionally try to explain and comment on ME researchh, or even contribute to it. And I advocate for more and better research.
It's been used for a long time to treat MS. There is anecdotal support, and it is available at some MS therapy centres, but studies haven't found good evidence for it.
mstrust.org.uk/a-z/hyperbar...?
mstrust.org.uk/a-z/hyperbar...?
Hyperbaric oxygen therapy
Hyperbaric oxygen therapy (HBO or HBOT, also called high dose oxygen therapy (HDOT)) involves breathing oxygen through a mask in a pressurised chamber, similar to a diving bell.
mstrust.org.uk
November 2, 2025 at 9:48 AM
It's been used for a long time to treat MS. There is anecdotal support, and it is available at some MS therapy centres, but studies haven't found good evidence for it.
mstrust.org.uk/a-z/hyperbar...?
mstrust.org.uk/a-z/hyperbar...?
Got you.
I thought that if psychologists started recognising their limits as helping people cope with a chronic illness, that would be a good thing.
I thought that if psychologists started recognising their limits as helping people cope with a chronic illness, that would be a good thing.
October 30, 2025 at 4:33 PM
Got you.
I thought that if psychologists started recognising their limits as helping people cope with a chronic illness, that would be a good thing.
I thought that if psychologists started recognising their limits as helping people cope with a chronic illness, that would be a good thing.
Sorry, where does it say that? I didn't read the full piece.
October 30, 2025 at 3:26 PM
Sorry, where does it say that? I didn't read the full piece.
Did they say why they took this fundamentally flawed approach?
October 30, 2025 at 11:07 AM
Did they say why they took this fundamentally flawed approach?
Hi Anna. Thanks for sharing – I've just donated. Enjoy the big birthday, it's what they are for
October 29, 2025 at 9:09 PM
Hi Anna. Thanks for sharing – I've just donated. Enjoy the big birthday, it's what they are for
Long ago, when Francis Collins was head of the NIH and briefly taking an interest in this illness, he said he thought that when ME/CFS was finally solved, it would be through discovering a previously unknown biological mechanism (didn't say fatigue specifically).
October 29, 2025 at 10:41 AM
Long ago, when Francis Collins was head of the NIH and briefly taking an interest in this illness, he said he thought that when ME/CFS was finally solved, it would be through discovering a previously unknown biological mechanism (didn't say fatigue specifically).
This paper claims neuroticism and other personality disorders in CFS and its methodology is exceptionally flawed. There is a thread on PR from way back, if you're interested. Probably not worth the effort. pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
October 29, 2025 at 10:38 AM
This paper claims neuroticism and other personality disorders in CFS and its methodology is exceptionally flawed. There is a thread on PR from way back, if you're interested. Probably not worth the effort. pmc.ncbi.nlm.nih.gov/articles/PMC...
They seem to use a lot of parameters in the logistic regression model, as well as not correcting for multiple comparisons in the standard comparison. I wonder if the small number of cases they have (particularly for males) is sufficient to support looking at that number of parameters.
October 24, 2025 at 12:08 PM
They seem to use a lot of parameters in the logistic regression model, as well as not correcting for multiple comparisons in the standard comparison. I wonder if the small number of cases they have (particularly for males) is sufficient to support looking at that number of parameters.
In his presentation, Robert Phair said they didn't find a difference in gene expression for ACOD1, so modified the hypothesis to use post-translational modification (prm) to explain the bio differences. But many genes/proteins are involved in ptm, and we might expect a GWAS signal for that.
October 21, 2025 at 7:37 PM
In his presentation, Robert Phair said they didn't find a difference in gene expression for ACOD1, so modified the hypothesis to use post-translational modification (prm) to explain the bio differences. But many genes/proteins are involved in ptm, and we might expect a GWAS signal for that.
Reposted by Simon McGrath
5) The most interesting presentations were those that collected a lot of novel data without a particular hypothesis, such as the whole-body PET scans by Dr. Michell James.
IMHO, we need more data and measurements, less theory and speculation.
IMHO, we need more data and measurements, less theory and speculation.
October 21, 2025 at 3:58 PM
5) The most interesting presentations were those that collected a lot of novel data without a particular hypothesis, such as the whole-body PET scans by Dr. Michell James.
IMHO, we need more data and measurements, less theory and speculation.
IMHO, we need more data and measurements, less theory and speculation.
This comment failed validation on your blog, even though I used my WP user id. Q: The Eric Fauman X post you link to says 70% of causal genes in GWAS are the one closest to the lead SNP, but its reference are in the replies, which can't be seen by non-X users. Can you supply? Thanks.
October 21, 2025 at 10:30 AM
This comment failed validation on your blog, even though I used my WP user id. Q: The Eric Fauman X post you link to says 70% of causal genes in GWAS are the one closest to the lead SNP, but its reference are in the replies, which can't be seen by non-X users. Can you supply? Thanks.