Simona Cristea
@simocristea.bsky.social
Genomics, LLMs, spatial cancer evo | Group leader @DanaFarber @Harvard | Head of Data Science at Hale Center for Pancreatic Cancer | PhD @eth
for anybody visiting France for >1 hour, it’s plain obvious why:
- food is fresh and real
- people walk a lot
- people enjoy life
- food is fresh and real
- people walk a lot
- people enjoy life
April 25, 2025 at 4:15 AM
for anybody visiting France for >1 hour, it’s plain obvious why:
- food is fresh and real
- people walk a lot
- people enjoy life
- food is fresh and real
- people walk a lot
- people enjoy life
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December 1, 2024 at 9:51 PM
However, it is important to keep in mind that people in different parts of the world do have different genetic make-ups. So, it might be that the difference in risk is not entirely environmentally-driven. Future studies will for sure look into this aspect specifically.
December 1, 2024 at 9:51 PM
However, it is important to keep in mind that people in different parts of the world do have different genetic make-ups. So, it might be that the difference in risk is not entirely environmentally-driven. Future studies will for sure look into this aspect specifically.
They found a mutational signature (aka a specific pattern of mutations) more common in locations associated with a higher risk of kidney cancer than in those with a lower risk. This might indicate that these higher-risk locations are associated with a higher exposure to an unknown mutagen.
December 1, 2024 at 9:51 PM
They found a mutational signature (aka a specific pattern of mutations) more common in locations associated with a higher risk of kidney cancer than in those with a lower risk. This might indicate that these higher-risk locations are associated with a higher exposure to an unknown mutagen.
In other words, how much of this risk can we potentially modulate? Also, what exactly in the environment is causing less/more risk for a cancer type?
A recent study did exactly this. The authors looked at 900 kidney tumors from different parts of the world.
A recent study did exactly this. The authors looked at 900 kidney tumors from different parts of the world.
December 1, 2024 at 9:51 PM
In other words, how much of this risk can we potentially modulate? Also, what exactly in the environment is causing less/more risk for a cancer type?
A recent study did exactly this. The authors looked at 900 kidney tumors from different parts of the world.
A recent study did exactly this. The authors looked at 900 kidney tumors from different parts of the world.
What if we looked at the correlation between somatic mutation composition and tumor incidence from cancers in different parts of the world?
Then we can get an idea of what fraction of cancer incidence is driven by the exact environment we live in.
Then we can get an idea of what fraction of cancer incidence is driven by the exact environment we live in.
December 1, 2024 at 9:51 PM
What if we looked at the correlation between somatic mutation composition and tumor incidence from cancers in different parts of the world?
Then we can get an idea of what fraction of cancer incidence is driven by the exact environment we live in.
Then we can get an idea of what fraction of cancer incidence is driven by the exact environment we live in.
i think this is one of the smaller problems of peer-review 😄
December 1, 2024 at 4:05 AM
i think this is one of the smaller problems of peer-review 😄
why? is it known by how much they can deviate from individual baseline?
December 1, 2024 at 4:04 AM
why? is it known by how much they can deviate from individual baseline?
wonderfully put! it’s an unbelievable time for medical progress
November 26, 2024 at 4:01 AM
wonderfully put! it’s an unbelievable time for medical progress
congrats! my first like/comment on here 😅
November 25, 2024 at 1:50 AM
congrats! my first like/comment on here 😅