This paper looks at single cell DNA seq data from normal & cancer tissues and computes how evolution is changing within each tissue.

In most cancers and half of normal tissues, the paper rejects a constant evolutionary rate - potentially explainable by mutations in driver genes.

t.co/P3LgFWbHMG

Contrary to what was thought - that immune cells cannot infiltrate the brain - anticancer active T cells do exist in the brain, specifically inside the bone marrow in the skull.

These exact cells might be the future of immune therapies against brain cancers.

www.nature.com/articles/d41...

Investing in sequencing tumors from multiple parts of the world is not wasting money. In fact, it benefits everybody

Here’s why: in practice, we have no idea why/when cells in our body mutate, either healthy aging or malignant shifts

How much does the environment contribute?