Hadley Sikes
@sikeslab.bsky.social
Willard Henry Dow Professor MIT Chemical Engineering, PI in AMR IRG, SMART, Singapore
Clinical diagnostics, mathematical modeling, protein engineering, redox metabolism
Clinical diagnostics, mathematical modeling, protein engineering, redox metabolism
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Hadley Sikes
@sikeslab.bsky.social
· Jan 24
Job Application - SMART
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portal.smart.mit.edu
We have an opening for a postdoctoral researcher with protein engineering skills in #AMR IRG at the CREATE campus in #Singapore, as part of the Singapore-MIT Alliance for Research and Technology. Here's the link to apply: portal.smart.mit.edu/careers/care... Fun group, interesting project!
This is very sad and wasteful. A lot of the value comes from longitudinal data. Stopping early wastes all of the startup costs. NIH cancels its first and largest study centered on women | Science | AAAS www.science.org/content/arti...
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
www.science.org
April 23, 2025 at 3:05 PM
This is very sad and wasteful. A lot of the value comes from longitudinal data. Stopping early wastes all of the startup costs. NIH cancels its first and largest study centered on women | Science | AAAS www.science.org/content/arti...
Wonderful essay by @francesarnold.bsky.social! A few points of wisdom resonating with me: finding that exploration/exploitation balance, navigating chemistry/engineering tension in differing motivations and values, importance of taking time to enjoy life with kids, importance of high expectations.
Priestley Medal address 2025: A random (mostly) uphill walk
A version of this essay will be presented at the American Chemical Society Spring 2025 meeting by 2025 Priestley Medal winner Frances H. Arnold. cen.acs.org/people/award...
A version of this essay will be presented at the American Chemical Society Spring 2025 meeting by 2025 Priestley Medal winner Frances H. Arnold. cen.acs.org/people/award...
Priestley Medal address 2025: A random (mostly) uphill walk
A version of this essay will be presented at the American Chemical Society Spring 2025 meeting by 2025 Priestley Medal winner Frances H. Arnold, Linus Pauling Professor of Chemical Engineering, Bioeng...
cen.acs.org
March 23, 2025 at 2:55 PM
Wonderful essay by @francesarnold.bsky.social! A few points of wisdom resonating with me: finding that exploration/exploitation balance, navigating chemistry/engineering tension in differing motivations and values, importance of taking time to enjoy life with kids, importance of high expectations.
My representative in Congress is holding a conference call now- my cellphone rang and I was given the option to stay on the line to join. She's taking questions from constituents live. It's remarkable direct outreach and people are giving voice to problems the chaos in government has created.
February 8, 2025 at 3:28 PM
My representative in Congress is holding a conference call now- my cellphone rang and I was given the option to stay on the line to join. She's taking questions from constituents live. It's remarkable direct outreach and people are giving voice to problems the chaos in government has created.
Reposted by Hadley Sikes
Cuts to the NIH are a strategy to strangle research universities not “reduce waste”
February 8, 2025 at 1:43 PM
Cuts to the NIH are a strategy to strangle research universities not “reduce waste”
Another engaging #AMR IRG January workshop is in the books. The group voted on what talks they wanted to hear, and we had a fun dinner at Umami10, celebrating another year working on diagnostics, therapies, and deeper understanding to allow both. #Singapore - #MIT Alliance, #CREATE Campus
January 25, 2025 at 3:45 AM
Another engaging #AMR IRG January workshop is in the books. The group voted on what talks they wanted to hear, and we had a fun dinner at Umami10, celebrating another year working on diagnostics, therapies, and deeper understanding to allow both. #Singapore - #MIT Alliance, #CREATE Campus
We have an opening for a postdoctoral researcher with protein engineering skills in #AMR IRG at the CREATE campus in #Singapore, as part of the Singapore-MIT Alliance for Research and Technology. Here's the link to apply: portal.smart.mit.edu/careers/care... Fun group, interesting project!
Job Application - SMART
×
Processing
Please wait, form submission in progress
...
portal.smart.mit.edu
January 24, 2025 at 1:53 PM
We have an opening for a postdoctoral researcher with protein engineering skills in #AMR IRG at the CREATE campus in #Singapore, as part of the Singapore-MIT Alliance for Research and Technology. Here's the link to apply: portal.smart.mit.edu/careers/care... Fun group, interesting project!
Banishing jetlag with a lunchtime walk in Clementi Woods Park #Singapore Weather is cool after all the rain!
January 15, 2025 at 6:22 AM
Banishing jetlag with a lunchtime walk in Clementi Woods Park #Singapore Weather is cool after all the rain!
Good morning #Singapore! Excited for a week of working on diagnostics and new ventures in #AMR Singapore-MIT Alliance for Research and Technology and for our year end company party #Thrixen
December 15, 2024 at 11:28 PM
Good morning #Singapore! Excited for a week of working on diagnostics and new ventures in #AMR Singapore-MIT Alliance for Research and Technology and for our year end company party #Thrixen
Reposted by Hadley Sikes
Back by popular demand, I present PPI Prediction Challenge #2.
My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.
Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...
1/n
My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.
Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...
1/n
PPI Prediction Challenge #2
For this protein-protein interaction prediction challenge, we present three target proteins: KRAS, RAF (the KRAS binding domain), and Mdm2. For each target protein, we are providing you a list of 8 po...
docs.google.com
December 10, 2024 at 9:45 PM
Back by popular demand, I present PPI Prediction Challenge #2.
My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.
Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...
1/n
My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.
Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...
1/n
"polyclonal antibody ... that recognizes hyperoxidized PRDX3 ... Owing to the limited supply, this antibody has been unavailable since publication of that study" Peroxiredoxins, super important and rudimentary tools for analysis! www.cell.com/molecular-ce...
5H7c: A rabbit monoclonal antibody detecting ferroptotic cells
Ferroptosis, a cell death pathway triggered by iron-catalyzed peroxidation of phospholipids, has been implicated in both disease progression and cancer treatment.1 A major challenge in studying ferroptosis has been the difficulty in detecting ferroptotic cells under physiological conditions, owing to the lack of a specific marker for ferroptosis.1 This obstacle was recently overcome by our study published in Molecular Cell, which identified hyperoxidized PRDX3 as a specific marker for ferroptosis.
www.cell.com
December 10, 2024 at 3:22 AM
"polyclonal antibody ... that recognizes hyperoxidized PRDX3 ... Owing to the limited supply, this antibody has been unavailable since publication of that study" Peroxiredoxins, super important and rudimentary tools for analysis! www.cell.com/molecular-ce...
Exciting things to come from this new lab! Prof. Kim does elegant work analyzing reaction mechanisms and transport phenomena and students will greatly benefit from learning from him! His latest paper: onlinelibrary.wiley.com/doi/full/10.... Congrats to DGIST on an excellent hiring decision.
December 7, 2024 at 4:04 PM
Exciting things to come from this new lab! Prof. Kim does elegant work analyzing reaction mechanisms and transport phenomena and students will greatly benefit from learning from him! His latest paper: onlinelibrary.wiley.com/doi/full/10.... Congrats to DGIST on an excellent hiring decision.
I always wonder if the common biomarkers in diagnostic tests are the best (including most abundant/technically easiest) or if some are common because there was some existing data and test developers all jumped on board. Glad this dataset exists! www.cell.com/cell/fulltex...
Atlas of the plasma proteome in health and disease in 53,026 adults
A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins
to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying
promising biomarkers...
www.cell.com
November 25, 2024 at 1:28 AM
I always wonder if the common biomarkers in diagnostic tests are the best (including most abundant/technically easiest) or if some are common because there was some existing data and test developers all jumped on board. Glad this dataset exists! www.cell.com/cell/fulltex...
In awe of the many lab members I've coauthored with who make it look easy when it isn't, and as a journal editor am always careful not to reject solid results on the basis of language (can be revised). Much respect to those researchers who have this extra skill.
Non-native English speakers need 50% more time to write a paper
When they do, they face a 2.5 times higher chance of being rejected because of language
journals.plos.org/plosbiology/...
When they do, they face a 2.5 times higher chance of being rejected because of language
journals.plos.org/plosbiology/...
November 25, 2024 at 1:21 AM
In awe of the many lab members I've coauthored with who make it look easy when it isn't, and as a journal editor am always careful not to reject solid results on the basis of language (can be revised). Much respect to those researchers who have this extra skill.