Sigurbjörn Markússon
@sigurbjornm.bsky.social
Structural Biology DPhil student - Oxford, Newstead lab. Interested in membrane protein structural biology.
Following identification of the gene in GWAS, we discovered that SLC45A4 is the sought after plasma membrane polyamine transporter, demonstrating transport in neurons. Our structures showed a novel plug domain on its large cytosolic domain, making it the first known autoinhibited MFS transporter!
August 21, 2025 at 11:22 AM
Following identification of the gene in GWAS, we discovered that SLC45A4 is the sought after plasma membrane polyamine transporter, demonstrating transport in neurons. Our structures showed a novel plug domain on its large cytosolic domain, making it the first known autoinhibited MFS transporter!