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Sigurbjörn Markússon

@sigurbjornm.bsky.social

36 followers 67 following 4 posts

Structural Biology DPhil student - Oxford, Newstead lab. Interested in membrane protein structural biology.

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Sigurbjörn Markússon @sigurbjornm.bsky.social · Aug 21

Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

www.nature.com

Reposted by Sigurbjörn Markússon

Oxford Biochemistry

@oxfordbiochemistry.bsky.social

Read the full story here: 📣Breakthrough discovery reveals new gene linked to chronic pain ➡️ bit.ly/202508_newst...

Cryo-Em structure of the SLC45A4 polyamine transporter depicted by a substantial yellow and green area, a purple mid-section, punctuated with turquoise and with the top third of the whole surrounded by a transparent 'membrane'-like structure

August 22, 2025 at 1:13 PM

Reposted by Sigurbjörn Markússon

Steve Middleton

@middletonsj.bsky.social

We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future!

www.nature.com/articles/s41...