Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
Signal Transduction and Targeted Therapy (STTT) | A Nature Portfolio journal | Impact Factor 52.7 | Q1 in Biochemistry, Cell Biology & Molecular Medicine | Open Access
Visit: https://www.nature.com/sigtrans/
Visit: https://www.nature.com/sigtrans/
Pinned
Welcome to the official Bluesky of Signal Transduction and Targeted Therapy (STTT) — a peer-reviewed, open-access Nature journal publishing high-impact research in signaling, targeted therapies & translational medicine.
🔗 Latest research: nature.com/sigtrans
✉️ Submit: nature.com/sttt/for-authors
🔗 Latest research: nature.com/sigtrans
✉️ Submit: nature.com/sttt/for-authors
Researchers elucidate the molecular basis of Cas12h1’s #nickase function, revealing its phage-related evolution and enabling the rational engineering of Cas12h1hf, a compact, high-fidelity #CRISPR tool for precise #GenomeEditing.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Molecular insights and rational engineering of a compact CRISPR-Cas effector Cas12h1 with a broad-spectrum PAM - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Molecular insights and rational engineering of a compact CRISPR-Cas effector Cas12h1 with a broad-spectrum PAM
doi.org
November 11, 2025 at 10:54 AM
Researchers elucidate the molecular basis of Cas12h1’s #nickase function, revealing its phage-related evolution and enabling the rational engineering of Cas12h1hf, a compact, high-fidelity #CRISPR tool for precise #GenomeEditing.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Highlighting the potential of natural compounds and their derivatives as less toxic, more effective preventive options for #Oncology by exploring their multilevel regulatory mechanisms, #TherapeuticTargets, and #DrugDelivery systems.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
November 11, 2025 at 4:30 AM
Highlighting the potential of natural compounds and their derivatives as less toxic, more effective preventive options for #Oncology by exploring their multilevel regulatory mechanisms, #TherapeuticTargets, and #DrugDelivery systems.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This review explores the multifactorial pathogenesis of #DiabeticNeuropathy and highlights emerging diagnostics, #neuroprotective strategies, and therapeutic targets—including gene and #StemCellTherapies. #DiabetesMellitus #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Diabetic neuropathy: cutting-edge research and future directions - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Diabetic neuropathy: cutting-edge research and future directions
doi.org
November 10, 2025 at 2:30 PM
This review explores the multifactorial pathogenesis of #DiabeticNeuropathy and highlights emerging diagnostics, #neuroprotective strategies, and therapeutic targets—including gene and #StemCellTherapies. #DiabetesMellitus #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
A comprehensive review of meningeal lymphatic vessels—their development, structure, and function—as well as the molecular mechanisms of injury, links to #CNS diseases, and factors regulating meningeal lymphatic function.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
November 10, 2025 at 1:02 PM
A comprehensive review of meningeal lymphatic vessels—their development, structure, and function—as well as the molecular mechanisms of injury, links to #CNS diseases, and factors regulating meningeal lymphatic function.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Combining the mTORC1/2 inhibitor #onatasertib with the #PD1antibody #toripalimab offers a manageable safety profile and promising efficacy in advanced #SolidTumors—especially recurrent or #MetastaticCervicalCancer—regardless of #PDL1 expression.
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
November 10, 2025 at 10:00 AM
Combining the mTORC1/2 inhibitor #onatasertib with the #PD1antibody #toripalimab offers a manageable safety profile and promising efficacy in advanced #SolidTumors—especially recurrent or #MetastaticCervicalCancer—regardless of #PDL1 expression.
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
#REGOMUNE - a phase II #ClinicalTrial of #Regorafenib + #Avelumab in advanced 'cold' #SoftTissueSarcoma—shows that anti-angiogenic therapy modulates the #TumorMicroenvironment and boosts immune-mediated tumor destruction. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
November 10, 2025 at 6:39 AM
#REGOMUNE - a phase II #ClinicalTrial of #Regorafenib + #Avelumab in advanced 'cold' #SoftTissueSarcoma—shows that anti-angiogenic therapy modulates the #TumorMicroenvironment and boosts immune-mediated tumor destruction. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Using the MiLi-FE method, this #STTT study developed AR@ENV—microglia-derived #Nanocarriers co-loaded with #Rapamycin & AR7—that promotes synchronized activation of #Macroautophagy & #CMA in #AlzheimersDisease therapy. #medsky
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
November 9, 2025 at 1:49 PM
Using the MiLi-FE method, this #STTT study developed AR@ENV—microglia-derived #Nanocarriers co-loaded with #Rapamycin & AR7—that promotes synchronized activation of #Macroautophagy & #CMA in #AlzheimersDisease therapy. #medsky
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
Reposted by Signal Transduction and Targeted Therapy
Chan Breaks Down the Need for Dose Escalation With Somatostatin Analogs in GEP-NETs @danafarber.bsky.social @harvardmed.bsky.social @nanets.bsky.social #NANETS25 #medtwitter #oncology www.onclive.com/view/chan-br...
Chan Breaks Down the Need for Dose Escalation With Somatostatin Analogs in GEP-NETs | OncLive
Jennifer Chan, MD, MPH, discusses dose escalation and interval shortening with somatostatin analogs for GEP-NETs and how SORENTO may shape treatment.
www.onclive.com
November 8, 2025 at 8:44 PM
Chan Breaks Down the Need for Dose Escalation With Somatostatin Analogs in GEP-NETs @danafarber.bsky.social @harvardmed.bsky.social @nanets.bsky.social #NANETS25 #medtwitter #oncology www.onclive.com/view/chan-br...
#Olverembatinib, a novel #MultiKinaseInhibitor, demonstrates strong efficacy and safety in SDH-deficient GISTs resistant to #TKIs, mechanistically suppressing #LipidUptake and #CD36-associated tumorigenic pathways. #GISTs #CD36
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
November 9, 2025 at 10:00 AM
#Olverembatinib, a novel #MultiKinaseInhibitor, demonstrates strong efficacy and safety in SDH-deficient GISTs resistant to #TKIs, mechanistically suppressing #LipidUptake and #CD36-associated tumorigenic pathways. #GISTs #CD36
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
A novel long-acting C5a-blocking cyclic peptide blocks the C5a–C5aR1 interaction to suppress #Hyperinflammation & maintain #ImmuneHomeostasis while reducing #Sepsis-induced innate immune & organ dysfunction. @fudan-university.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
November 9, 2025 at 2:15 AM
A novel long-acting C5a-blocking cyclic peptide blocks the C5a–C5aR1 interaction to suppress #Hyperinflammation & maintain #ImmuneHomeostasis while reducing #Sepsis-induced innate immune & organ dysfunction. @fudan-university.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This review highlights the role of #ProteinKinases in #NeurodegenerativeDiseases and explores kinase-targeted strategies—including inhibitors, #AntisenseOligonucleotides, and #GeneTherapy—for early intervention and disease management.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
November 8, 2025 at 2:34 PM
This review highlights the role of #ProteinKinases in #NeurodegenerativeDiseases and explores kinase-targeted strategies—including inhibitors, #AntisenseOligonucleotides, and #GeneTherapy—for early intervention and disease management.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
STYK1 hyperactivates Wnt/β-catenin pathway in APC-independent #PancreaticCancer via GSK3β sequestration, suggesting that disrupting STYK1–β-catenin or STYK1–GSK3β interactions may suppress tumor progression. @ualberta.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
November 8, 2025 at 1:31 PM
STYK1 hyperactivates Wnt/β-catenin pathway in APC-independent #PancreaticCancer via GSK3β sequestration, suggesting that disrupting STYK1–β-catenin or STYK1–GSK3β interactions may suppress tumor progression. @ualberta.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Reposted by Signal Transduction and Targeted Therapy
Yale Study Sheds Light on Cellular Resistance to Osimertinib in Adenocarcinoma @yalecancer.bsky.social #oncology
www.onclive.com/view/yale-st...
www.onclive.com/view/yale-st...
Yale Study Sheds Light on Cellular Resistance to Osimertinib in Adenocarcinoma | OncLive
Protein METTL7A plays key role in resistance to drugs targeting EGFR-mutant lung adenocarcinoma.
www.onclive.com
November 7, 2025 at 8:28 PM
Yale Study Sheds Light on Cellular Resistance to Osimertinib in Adenocarcinoma @yalecancer.bsky.social #oncology
www.onclive.com/view/yale-st...
www.onclive.com/view/yale-st...
Reposted by Signal Transduction and Targeted Therapy
SWOG S1605: UroAmp utDNA Predicts Immunotherapy Response in Bladder Cancer
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
November 7, 2025 at 9:46 PM
SWOG S1605: UroAmp utDNA Predicts Immunotherapy Response in Bladder Cancer
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Reposted by Signal Transduction and Targeted Therapy
Apply to the #LeadershipYOU Clinical Research Leadership Program (CRLP)!
For U.S. ACG member physicians 2-15 years post-fellowship who have received grant funding as a PI/Co-PI (non-trainee, non-fellow) in the last 10 years
Applications due November 14
🌟gi.org/CRLP
For U.S. ACG member physicians 2-15 years post-fellowship who have received grant funding as a PI/Co-PI (non-trainee, non-fellow) in the last 10 years
Applications due November 14
🌟gi.org/CRLP
November 7, 2025 at 11:19 PM
Apply to the #LeadershipYOU Clinical Research Leadership Program (CRLP)!
For U.S. ACG member physicians 2-15 years post-fellowship who have received grant funding as a PI/Co-PI (non-trainee, non-fellow) in the last 10 years
Applications due November 14
🌟gi.org/CRLP
For U.S. ACG member physicians 2-15 years post-fellowship who have received grant funding as a PI/Co-PI (non-trainee, non-fellow) in the last 10 years
Applications due November 14
🌟gi.org/CRLP
This review highlights lactate’s role in shaping the #TumorMicroEnvironment and discusses therapeutic strategies targeting #LactateDehydrogenase and MCT to exploit #LactateMetabolism as a promising strategy to enhance #CancerTherapy effectiveness.
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
November 8, 2025 at 4:30 AM
This review highlights lactate’s role in shaping the #TumorMicroEnvironment and discusses therapeutic strategies targeting #LactateDehydrogenase and MCT to exploit #LactateMetabolism as a promising strategy to enhance #CancerTherapy effectiveness.
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
#UvealMelanoma cells with a GNA11Q209L or GNAQQ209L mutation secrete #VEGF to induce #EndothelialPermeability, facilitating UM cell transmigration across the endothelium, while systemic #Aflibercept & KAI treatment inhibit circulating UM cells.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
November 8, 2025 at 1:00 AM
#UvealMelanoma cells with a GNA11Q209L or GNAQQ209L mutation secrete #VEGF to induce #EndothelialPermeability, facilitating UM cell transmigration across the endothelium, while systemic #Aflibercept & KAI treatment inhibit circulating UM cells.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
Single-nucleus and #SpatialTranscriptomics reveal how #mesothelial and immune cell interactions drive #CVB3-induced #FulminantMyocarditis, identifying the IFN-γ/Spi1 axis as a key therapeutic target and demonstrating IVIG’s efficacy.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
November 7, 2025 at 2:30 PM
Single-nucleus and #SpatialTranscriptomics reveal how #mesothelial and immune cell interactions drive #CVB3-induced #FulminantMyocarditis, identifying the IFN-γ/Spi1 axis as a key therapeutic target and demonstrating IVIG’s efficacy.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Src inhibitors reverse MCL-1 accumulation induced by MCL-1 inhibitors in #AcuteMyeloidLeukemia (AML) cells, by promoting degradative #Ubiquitination, disrupting STAT-3-mediated transcription, and inducing NOXA-mediated MCL-1 degradation.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
November 7, 2025 at 1:04 PM
Src inhibitors reverse MCL-1 accumulation induced by MCL-1 inhibitors in #AcuteMyeloidLeukemia (AML) cells, by promoting degradative #Ubiquitination, disrupting STAT-3-mediated transcription, and inducing NOXA-mediated MCL-1 degradation.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This review highlights AXL as a key #oncogenic driver and #antiviral target, detailing its roles in #tumor progression and #DrugResistance, and explores emerging AXL-targeted therapies for improving outcomes in #cancer. @bostonchildrens.bsky.social
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
November 7, 2025 at 10:00 AM
This review highlights AXL as a key #oncogenic driver and #antiviral target, detailing its roles in #tumor progression and #DrugResistance, and explores emerging AXL-targeted therapies for improving outcomes in #cancer. @bostonchildrens.bsky.social
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
Reviewing the cellular response & cross-talk in #LiverRepair & regeneration, the signaling pathways involved, & #MetabolicReprogramming of liver cells, with insights into innovations in #Diagnostic & therapeutic strategies.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
November 7, 2025 at 7:57 AM
Reviewing the cellular response & cross-talk in #LiverRepair & regeneration, the signaling pathways involved, & #MetabolicReprogramming of liver cells, with insights into innovations in #Diagnostic & therapeutic strategies.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This review examines #Copper biology and the emerging role of #Cuproptosis in #Cancer, outlining its mechanisms, dual roles in #tumor regulation, and therapeutic promise of copper modulation for future #Anticancer strategies. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
November 6, 2025 at 2:51 PM
This review examines #Copper biology and the emerging role of #Cuproptosis in #Cancer, outlining its mechanisms, dual roles in #tumor regulation, and therapeutic promise of copper modulation for future #Anticancer strategies. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Summarizing the #Epidemiology of virus-related tumors, infectivity, and #Oncogenicity mechanisms of #OncogenicViruses, with a discussion on the current therapeutic strategies for virus-related tumors.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
November 6, 2025 at 12:49 PM
Summarizing the #Epidemiology of virus-related tumors, infectivity, and #Oncogenicity mechanisms of #OncogenicViruses, with a discussion on the current therapeutic strategies for virus-related tumors.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This review explores #platelet structure, signaling, and function, highlighting their central roles in #hemostasis, #immunity, and tissue repair while emphasizing how dysregulated activity drives #thrombosis and #cancer. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
November 6, 2025 at 10:01 AM
This review explores #platelet structure, signaling, and function, highlighting their central roles in #hemostasis, #immunity, and tissue repair while emphasizing how dysregulated activity drives #thrombosis and #cancer. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Insights into how adhesion G protein-coupled receptor 133 contributes to #BoneFormation through local cell-cell interactions between osteoblasts and osteoclasts, making it a promising candidate for treating osteopenic conditions.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
November 6, 2025 at 8:15 AM
Insights into how adhesion G protein-coupled receptor 133 contributes to #BoneFormation through local cell-cell interactions between osteoblasts and osteoclasts, making it a promising candidate for treating osteopenic conditions.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...