Shubham Sharma
@shubham-s04.bsky.social
Post-Doctoral Fellow, Dept of Biological Sciences & Engineering, IIT Gandhinagar, India. EMBO Fellow, France.
#NucleicAcids #G4 #cancer #diagnosis #therapeutics
#NucleicAcids #G4 #cancer #diagnosis #therapeutics
Reposted by Shubham Sharma
Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC.
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
August 26, 2025 at 6:41 AM
Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC.
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
Can we fight colorectal cancer by unfolding lncRNA secondary structures?
Yes, it’s very likely!
🚀Excited to share our latest publication in @springernature.com - BMC Biology
!
🔗 Read: doi.org/10.1186/s129... (1/9)
#G4 #lncRNA #RNA #CancerResearch #IITGN #ICMUB #EMBO
Yes, it’s very likely!
🚀Excited to share our latest publication in @springernature.com - BMC Biology
!
🔗 Read: doi.org/10.1186/s129... (1/9)
#G4 #lncRNA #RNA #CancerResearch #IITGN #ICMUB #EMBO
Pharmacomodulation of G-quadruplexes in long non-coding RNAs dysregulated in colorectal cancer - BMC Biology
Background Non-coding RNAs (ncRNAs) in human cells constitute a substantial portion of the transcriptome but do not lead to protein synthesis. Among them, long non-coding RNAs (lncRNAs, > 200 nucleoti...
doi.org
August 26, 2025 at 6:24 AM
Can we fight colorectal cancer by unfolding lncRNA secondary structures?
Yes, it’s very likely!
🚀Excited to share our latest publication in @springernature.com - BMC Biology
!
🔗 Read: doi.org/10.1186/s129... (1/9)
#G4 #lncRNA #RNA #CancerResearch #IITGN #ICMUB #EMBO
Yes, it’s very likely!
🚀Excited to share our latest publication in @springernature.com - BMC Biology
!
🔗 Read: doi.org/10.1186/s129... (1/9)
#G4 #lncRNA #RNA #CancerResearch #IITGN #ICMUB #EMBO
What began as a spark of curiosity 4+ yrs ago led us through uncharted territory—mining massive data to decode G4 formation in cancer-associated lncRNAs.
Our dataset is now out in Scientific Data (@nature.com)!
Read: doi.org/10.1038/s415... 1/6
#G4 #lncRNA #RNA #CancerResearch #IITGN
Our dataset is now out in Scientific Data (@nature.com)!
Read: doi.org/10.1038/s415... 1/6
#G4 #lncRNA #RNA #CancerResearch #IITGN
A Dataset Curated for the Assessment of G4s in the LncRNAs Dysregulated in Various Human Cancers - Scientific Data
Scientific Data - A Dataset Curated for the Assessment of G4s in the LncRNAs Dysregulated in Various Human Cancers
doi.org
August 26, 2025 at 6:18 AM
What began as a spark of curiosity 4+ yrs ago led us through uncharted territory—mining massive data to decode G4 formation in cancer-associated lncRNAs.
Our dataset is now out in Scientific Data (@nature.com)!
Read: doi.org/10.1038/s415... 1/6
#G4 #lncRNA #RNA #CancerResearch #IITGN
Our dataset is now out in Scientific Data (@nature.com)!
Read: doi.org/10.1038/s415... 1/6
#G4 #lncRNA #RNA #CancerResearch #IITGN