Shounak Gupta
@shounakgupta.bsky.social
Reposted by Shounak Gupta
Forgot the BRAF photo.
January 23, 2025 at 6:00 PM
Forgot the BRAF photo.
Reposted by Shounak Gupta
It is nicely positive for SMA, caldesmon and desmin (not shown). But- it is also positive for both MyoD1 and myogenin. NGS found SRF::NCOA2. Leiomyomatous spindle cell RMS. The NCOA2 fused ones usually have a good prognosis. C. Dehner, now at IU, wrote a nice paper pubmed.ncbi.nlm.nih.gov/37422156/
Fusion-driven Spindle Cell Rhabdomyosarcomas of Bone and Soft Tissue: A Clinicopathologic and Molecular Genetic Study of 25 Cases - PubMed
The evolving classification of rhabdomyosarcoma (RMS) now includes spindle cell RMS (SRMS). Bone/soft tissue SRMS often harbor TFCP2, or less often MEIS1 rearrangements. We studied 25 fusion-driven SR...
pubmed.ncbi.nlm.nih.gov
January 6, 2025 at 8:30 PM
It is nicely positive for SMA, caldesmon and desmin (not shown). But- it is also positive for both MyoD1 and myogenin. NGS found SRF::NCOA2. Leiomyomatous spindle cell RMS. The NCOA2 fused ones usually have a good prognosis. C. Dehner, now at IU, wrote a nice paper pubmed.ncbi.nlm.nih.gov/37422156/