ShinyBlackShoe (Calum Polwart)
@shinyblackshoe.bsky.social
🏴 consultant #oncology pharmacist working in 🏴 🇬🇧. #PharmSky #OncoSky
Interested in #OncoPharm, Data science, #Rstats, Visualisation. ⛵🍝🥌🏞️📷🖥️
Self declared geek.
Breast #bcsm, Prostate #pcsm, Lower GI #crcsm, Upper GI #esocsm & HPB #hpbcsm
chemo.org.uk
Interested in #OncoPharm, Data science, #Rstats, Visualisation. ⛵🍝🥌🏞️📷🖥️
Self declared geek.
Breast #bcsm, Prostate #pcsm, Lower GI #crcsm, Upper GI #esocsm & HPB #hpbcsm
chemo.org.uk
Have we changed what a QALY means? Because I didn't think it had anything to do with what an alternative healthcare might cost and gain (although you can compare). I thought this was about the value that a person added to the economy when well? (Or rather the cost when unwell)
October 11, 2025 at 10:00 PM
Have we changed what a QALY means? Because I didn't think it had anything to do with what an alternative healthcare might cost and gain (although you can compare). I thought this was about the value that a person added to the economy when well? (Or rather the cost when unwell)
3 books to read...? Jinpa's book only takes a couple of days to read...
October 4, 2025 at 8:48 AM
3 books to read...? Jinpa's book only takes a couple of days to read...
Perhaps better considered with a three phase model.
Animals spend 85% of the day in Soothing, 5% in fight and 10% in drive.
It is very difficult to be compassionate when not in the soothing system
Animals spend 85% of the day in Soothing, 5% in fight and 10% in drive.
It is very difficult to be compassionate when not in the soothing system
October 4, 2025 at 8:23 AM
Perhaps better considered with a three phase model.
Animals spend 85% of the day in Soothing, 5% in fight and 10% in drive.
It is very difficult to be compassionate when not in the soothing system
Animals spend 85% of the day in Soothing, 5% in fight and 10% in drive.
It is very difficult to be compassionate when not in the soothing system
Definition is really to "suffer with"
October 4, 2025 at 8:23 AM
Definition is really to "suffer with"
26%pt lower rises in QTc (>30msec shift) with the lower dose.
But S3 eTable 3 reports for R-600mg 3.2% of patients had QTc > 480msec 𝒄𝒇 0.5% in R-400mg group.
Yet eTable 2 reports CTC QT interval prolongation as: 0.5 𝒗𝒔 1.6% for R-400 𝒗𝒔 R-600.
But S3 eTable 3 reports for R-600mg 3.2% of patients had QTc > 480msec 𝒄𝒇 0.5% in R-400mg group.
Yet eTable 2 reports CTC QT interval prolongation as: 0.5 𝒗𝒔 1.6% for R-400 𝒗𝒔 R-600.
September 27, 2025 at 8:21 AM
26%pt lower rises in QTc (>30msec shift) with the lower dose.
But S3 eTable 3 reports for R-600mg 3.2% of patients had QTc > 480msec 𝒄𝒇 0.5% in R-400mg group.
Yet eTable 2 reports CTC QT interval prolongation as: 0.5 𝒗𝒔 1.6% for R-400 𝒗𝒔 R-600.
But S3 eTable 3 reports for R-600mg 3.2% of patients had QTc > 480msec 𝒄𝒇 0.5% in R-400mg group.
Yet eTable 2 reports CTC QT interval prolongation as: 0.5 𝒗𝒔 1.6% for R-400 𝒗𝒔 R-600.
Why do we even need rules.
I can't see that you'd have any issue with this code snippet:
I can't see that you'd have any issue with this code snippet:
September 24, 2025 at 8:03 PM
Why do we even need rules.
I can't see that you'd have any issue with this code snippet:
I can't see that you'd have any issue with this code snippet:
Interesting article suggesting we turn all of what we are taught in academia about how to write stuff on its head...
I think this is exactly the sort of thing @mikemorrison.bsky.social et al have been saying with posters. While there is "logic" to how we learn to do it, if your audience hasn't...
I think this is exactly the sort of thing @mikemorrison.bsky.social et al have been saying with posters. While there is "logic" to how we learn to do it, if your audience hasn't...
August 10, 2025 at 8:47 AM
Interesting article suggesting we turn all of what we are taught in academia about how to write stuff on its head...
I think this is exactly the sort of thing @mikemorrison.bsky.social et al have been saying with posters. While there is "logic" to how we learn to do it, if your audience hasn't...
I think this is exactly the sort of thing @mikemorrison.bsky.social et al have been saying with posters. While there is "logic" to how we learn to do it, if your audience hasn't...
At #ExtremeRobots Newcastle @extremerobots.bsky.social where my sun is rather keen to win a CO2YOU machine to making him fizzy water...
(I can't stand the stuff...)
(I can't stand the stuff...)
July 20, 2025 at 12:02 PM
At #ExtremeRobots Newcastle @extremerobots.bsky.social where my sun is rather keen to win a CO2YOU machine to making him fizzy water...
(I can't stand the stuff...)
(I can't stand the stuff...)
Hand cranked windows are for youngsters!
I can see a role for a captcha style image. ... Name this and describe it's use...
I can see a role for a captcha style image. ... Name this and describe it's use...
July 13, 2025 at 3:14 AM
Hand cranked windows are for youngsters!
I can see a role for a captcha style image. ... Name this and describe it's use...
I can see a role for a captcha style image. ... Name this and describe it's use...
I've come to symptom control session, running at same time as proffered papers session at #esmogi25. I'm hoping someone will skeet if something dramatic happens at that session!
I'm wondering what message @myesmo.bsky.social were sending running symptom control alongside a proffered papers session
I'm wondering what message @myesmo.bsky.social were sending running symptom control alongside a proffered papers session
July 4, 2025 at 2:56 PM
I've come to symptom control session, running at same time as proffered papers session at #esmogi25. I'm hoping someone will skeet if something dramatic happens at that session!
I'm wondering what message @myesmo.bsky.social were sending running symptom control alongside a proffered papers session
I'm wondering what message @myesmo.bsky.social were sending running symptom control alongside a proffered papers session
I've come to symptom control session, running at same time as proffered papers session at #esmogi25. I'm hoping someone will skeet if something dramatic happens at that session!
I'm wondering what message @myesmo.bsky.social were sending running symptom control alongside a proffered papers session
I'm wondering what message @myesmo.bsky.social were sending running symptom control alongside a proffered papers session
July 4, 2025 at 2:55 PM
I've come to symptom control session, running at same time as proffered papers session at #esmogi25. I'm hoping someone will skeet if something dramatic happens at that session!
I'm wondering what message @myesmo.bsky.social were sending running symptom control alongside a proffered papers session
I'm wondering what message @myesmo.bsky.social were sending running symptom control alongside a proffered papers session
Wondering why I ask? Well has anyone ever seen a HR 0.17 for an adjuvant cancer Tx before?
Tumour specific cancer vaccine in adjuvant pancreatic cancer
Tumour specific cancer vaccine in adjuvant pancreatic cancer
July 4, 2025 at 12:40 PM
Wondering why I ask? Well has anyone ever seen a HR 0.17 for an adjuvant cancer Tx before?
Tumour specific cancer vaccine in adjuvant pancreatic cancer
Tumour specific cancer vaccine in adjuvant pancreatic cancer
Very valid point being made that with ADCs are given till progression, whereas Mab + Chemo is usually induction then maintenance Mab.
Toxicity of prolonged Tx with ADC is challenging. And we need a strategy to escalate / de-esecalate / holidays
In 🇬🇧(🏴) treatment breaks w/o evidence not 💰
Toxicity of prolonged Tx with ADC is challenging. And we need a strategy to escalate / de-esecalate / holidays
In 🇬🇧(🏴) treatment breaks w/o evidence not 💰
July 4, 2025 at 10:27 AM
Very valid point being made that with ADCs are given till progression, whereas Mab + Chemo is usually induction then maintenance Mab.
Toxicity of prolonged Tx with ADC is challenging. And we need a strategy to escalate / de-esecalate / holidays
In 🇬🇧(🏴) treatment breaks w/o evidence not 💰
Toxicity of prolonged Tx with ADC is challenging. And we need a strategy to escalate / de-esecalate / holidays
In 🇬🇧(🏴) treatment breaks w/o evidence not 💰
And CAR-T might be coming to Gastric Ca.
2 weeks hospital stay for every CAR-T infusion. Multiple infusions are needed to get penetration in the tumour.
#OncoPharm - do you have inpatient capabilities to support these patients given CAR-T has been the blood cancer guys toy until now?
2 weeks hospital stay for every CAR-T infusion. Multiple infusions are needed to get penetration in the tumour.
#OncoPharm - do you have inpatient capabilities to support these patients given CAR-T has been the blood cancer guys toy until now?
July 4, 2025 at 10:27 AM
And CAR-T might be coming to Gastric Ca.
2 weeks hospital stay for every CAR-T infusion. Multiple infusions are needed to get penetration in the tumour.
#OncoPharm - do you have inpatient capabilities to support these patients given CAR-T has been the blood cancer guys toy until now?
2 weeks hospital stay for every CAR-T infusion. Multiple infusions are needed to get penetration in the tumour.
#OncoPharm - do you have inpatient capabilities to support these patients given CAR-T has been the blood cancer guys toy until now?
#ESMOGI25
Better outcomes for Claudin antibodies in patients who have well managed CINV
*Requires 4 drug Antiemetic including Dex*
Make sure your protocols are good #OncoPharm
Better outcomes for Claudin antibodies in patients who have well managed CINV
*Requires 4 drug Antiemetic including Dex*
Make sure your protocols are good #OncoPharm
July 4, 2025 at 10:27 AM
#ESMOGI25
Better outcomes for Claudin antibodies in patients who have well managed CINV
*Requires 4 drug Antiemetic including Dex*
Make sure your protocols are good #OncoPharm
Better outcomes for Claudin antibodies in patients who have well managed CINV
*Requires 4 drug Antiemetic including Dex*
Make sure your protocols are good #OncoPharm
#ESMOGI25
Zanidatamab+chemo even with regular loperamide = ¼ patients Grade 3 diarrhoea
Brace yourselves #OncoPharm
Zanidatamab+chemo even with regular loperamide = ¼ patients Grade 3 diarrhoea
Brace yourselves #OncoPharm
July 4, 2025 at 10:27 AM
#ESMOGI25
Zanidatamab+chemo even with regular loperamide = ¼ patients Grade 3 diarrhoea
Brace yourselves #OncoPharm
Zanidatamab+chemo even with regular loperamide = ¼ patients Grade 3 diarrhoea
Brace yourselves #OncoPharm
Reflex test all Gastric Patients at diagnosis. Live with the fact you are testing some non-metastatic patients to get faster results for the metastatic ones.
And test everything at once not sequentially.
#ESMOGI25
And test everything at once not sequentially.
#ESMOGI25
July 3, 2025 at 5:11 PM
Reflex test all Gastric Patients at diagnosis. Live with the fact you are testing some non-metastatic patients to get faster results for the metastatic ones.
And test everything at once not sequentially.
#ESMOGI25
And test everything at once not sequentially.
#ESMOGI25
July 3, 2025 at 12:29 PM
Dr Chan telling us we should be more excited about TIGIT IO than LAG3 in HCC.
Now I know science is about facts... But I like the name TIGIT so I'm hoping it wins.
#ESMOGI25
Now I know science is about facts... But I like the name TIGIT so I'm hoping it wins.
#ESMOGI25
July 3, 2025 at 10:09 AM
Dr Chan telling us we should be more excited about TIGIT IO than LAG3 in HCC.
Now I know science is about facts... But I like the name TIGIT so I'm hoping it wins.
#ESMOGI25
Now I know science is about facts... But I like the name TIGIT so I'm hoping it wins.
#ESMOGI25
Slide below shows the development plan...
😱
😱
July 2, 2025 at 2:57 PM
Slide below shows the development plan...
😱
😱
Vaccines also not effective in big metastatic disease. But it might be useful in the prevention / adjuvant / minimal residual disease context...
July 2, 2025 at 11:42 AM
Vaccines also not effective in big metastatic disease. But it might be useful in the prevention / adjuvant / minimal residual disease context...
Especially as the immune system round PDAC is an immune desert!
It's not that there are no T Cells. It's the T cells are disfunctional. There was re too many myeloid cells...
It's not that there are no T Cells. It's the T cells are disfunctional. There was re too many myeloid cells...
July 2, 2025 at 11:35 AM
Especially as the immune system round PDAC is an immune desert!
It's not that there are no T Cells. It's the T cells are disfunctional. There was re too many myeloid cells...
It's not that there are no T Cells. It's the T cells are disfunctional. There was re too many myeloid cells...
I guess we don't need to be thinking IO is the way forward in PDAC...
July 2, 2025 at 11:35 AM
I guess we don't need to be thinking IO is the way forward in PDAC...