Shinji Izuka
@shinjiizuka.bsky.social
Rheumatologist, M.D., Ph.D. | myositis, lupus, bioinformatics | @bmj_rmdopen, @ACRheum International Adviser, @lindaunobel | 🏐⚽️🐕
B cell-targeted therapies (CAR-T, T cell engagers) are reshaping autoimmune disease treatment.
In my editorial, I discuss how mass spectrometry dissection of anti-PL12 antibodies in #ASyS (Ali & Troelnikov et al.) may pave the way for precision B cell therapies.
doi.org/10.1093/rheu...
In my editorial, I discuss how mass spectrometry dissection of anti-PL12 antibodies in #ASyS (Ali & Troelnikov et al.) may pave the way for precision B cell therapies.
doi.org/10.1093/rheu...
Beyond simple positivity: dissecting anti-PL-12 antibodies as a blueprint for future therapeutics in anti-synthetase syndrome
Shinji Izuka; Beyond simple positivity: dissecting anti-PL-12 antibodies as a blueprint for future therapeutics in anti-synthetase syndrome, Rheumatology,
doi.org
August 22, 2025 at 11:58 AM
B cell-targeted therapies (CAR-T, T cell engagers) are reshaping autoimmune disease treatment.
In my editorial, I discuss how mass spectrometry dissection of anti-PL12 antibodies in #ASyS (Ali & Troelnikov et al.) may pave the way for precision B cell therapies.
doi.org/10.1093/rheu...
In my editorial, I discuss how mass spectrometry dissection of anti-PL12 antibodies in #ASyS (Ali & Troelnikov et al.) may pave the way for precision B cell therapies.
doi.org/10.1093/rheu...
🦠 Early methotrexate use was associated with a 24 % lower rate of serious infections in a UK early-RA cohort (Adas et al.).
📖 My editorial asks whether MTX’s immunomodulating—rather than purely immunosuppressive—effects explain this paradox.
doi.org/10.1093/rheu...
📖 My editorial asks whether MTX’s immunomodulating—rather than purely immunosuppressive—effects explain this paradox.
doi.org/10.1093/rheu...
More than an immunosuppressant—lower serious infection rates with methotrexate in early rheumatoid arthritis
Shinji Izuka; More than an immunosuppressant—lower serious infection rates with methotrexate in early rheumatoid arthritis, Rheumatology, , keaf354, https:
doi.org
June 28, 2025 at 8:02 AM
🦠 Early methotrexate use was associated with a 24 % lower rate of serious infections in a UK early-RA cohort (Adas et al.).
📖 My editorial asks whether MTX’s immunomodulating—rather than purely immunosuppressive—effects explain this paradox.
doi.org/10.1093/rheu...
📖 My editorial asks whether MTX’s immunomodulating—rather than purely immunosuppressive—effects explain this paradox.
doi.org/10.1093/rheu...
Don't miss this brilliant paper! It really hit the nail on the head for some key challenges in managing #lupus. Was happy to make a small contribution💡
NEW for #LUPUS2025—ERN ReCONNET–SLICC–SLEuro expert consensus on the therapeutic management of rare systemic #lupus erythematosus manifestations bit.ly/3YXEmAO #SLE #Medsky #Rheumsky
Free to read with registration on lancet.com (also free)
Free to read with registration on lancet.com (also free)
May 24, 2025 at 11:01 PM
Don't miss this brilliant paper! It really hit the nail on the head for some key challenges in managing #lupus. Was happy to make a small contribution💡
Reposted by Shinji Izuka
NEW for #LUPUS2025—ERN ReCONNET–SLICC–SLEuro expert consensus on the therapeutic management of rare systemic #lupus erythematosus manifestations bit.ly/3YXEmAO #SLE #Medsky #Rheumsky
Free to read with registration on lancet.com (also free)
Free to read with registration on lancet.com (also free)
May 23, 2025 at 10:32 PM
NEW for #LUPUS2025—ERN ReCONNET–SLICC–SLEuro expert consensus on the therapeutic management of rare systemic #lupus erythematosus manifestations bit.ly/3YXEmAO #SLE #Medsky #Rheumsky
Free to read with registration on lancet.com (also free)
Free to read with registration on lancet.com (also free)
📝 Delighted to share our latest research!
Integration of transcriptome + immunophenotyping reveals two distinct B-cell–driven clusters across 6 IMDs — #SLE #RA #SSc #IIM #MCTD #LVV
🔔 Naïve B–dominant cluster
⬆️ IFN & ABC signature
🚨 Higher flare rate
rmdopen.bmj.com/content/11/2...
Integration of transcriptome + immunophenotyping reveals two distinct B-cell–driven clusters across 6 IMDs — #SLE #RA #SSc #IIM #MCTD #LVV
🔔 Naïve B–dominant cluster
⬆️ IFN & ABC signature
🚨 Higher flare rate
rmdopen.bmj.com/content/11/2...
Integration of transcriptome and immunophenotyping data highlights differences in the pathogenetic kinetics of B cells across immune-mediated disease
Objective To elucidate crucial immune cell subsets and associated immunological pathways by stratifying patients with immune-mediated diseases (IMDs) using immunophenotyping and transcriptomic approac...
rmdopen.bmj.com
April 10, 2025 at 11:14 AM
After a fulfilling four-year journey, I’m proud to share that I’ve officially completed my #PhD. It’s been an incredibly rewarding experience! I’m deeply grateful to everyone who supported me along the way.
March 24, 2025 at 12:43 PM
After a fulfilling four-year journey, I’m proud to share that I’ve officially completed my #PhD. It’s been an incredibly rewarding experience! I’m deeply grateful to everyone who supported me along the way.
🔔 Monocytes & Macrophages in #Myositis
— insights from our latest review!
✅ Chemokine-driven monocyte recruitment into inflamed tissue
✅ Markers predicting severity & prognosis in ILD
✅ Dysregulated IFN sig. & mitochondrial stress driving pathology
🔓 www.frontiersin.org/journals/imm...
— insights from our latest review!
✅ Chemokine-driven monocyte recruitment into inflamed tissue
✅ Markers predicting severity & prognosis in ILD
✅ Dysregulated IFN sig. & mitochondrial stress driving pathology
🔓 www.frontiersin.org/journals/imm...
March 20, 2025 at 8:14 AM
🔔 Monocytes & Macrophages in #Myositis
— insights from our latest review!
✅ Chemokine-driven monocyte recruitment into inflamed tissue
✅ Markers predicting severity & prognosis in ILD
✅ Dysregulated IFN sig. & mitochondrial stress driving pathology
🔓 www.frontiersin.org/journals/imm...
— insights from our latest review!
✅ Chemokine-driven monocyte recruitment into inflamed tissue
✅ Markers predicting severity & prognosis in ILD
✅ Dysregulated IFN sig. & mitochondrial stress driving pathology
🔓 www.frontiersin.org/journals/imm...
Muscle Tissue Transcriptome of Idiopathic Inflammatory Myopathy Reflects the Muscle Damage Process by Monocytes and Presence of Skin Lesions
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Muscle Tissue Transcriptome of Idiopathic Inflammatory Myopathy Reflects the Muscle Damage Process by Monocytes and Presence of Skin Lesions
Objective We aim to investigate transcriptomic and immunophenotypic features of muscle specimens from patients with idiopathic inflammatory myopathy (IIM). Methods Bulk RNA-sequencing was performe...
acrjournals.onlinelibrary.wiley.com
March 13, 2025 at 12:24 PM
Muscle Tissue Transcriptome of Idiopathic Inflammatory Myopathy Reflects the Muscle Damage Process by Monocytes and Presence of Skin Lesions
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Machine learning–driven immunophenotypic stratification of mixed connective tissue disease, corroborating the clinical heterogeneity
academic.oup.com/rheumatology...
academic.oup.com/rheumatology...
Machine learning–driven immunophenotypic stratification of mixed connective tissue disease, corroborating the clinical heterogeneity
AbstractObjective. The objective of this study was to stratify patients with MCTD, based on their immunophenotype.Methods. We analysed the immunophenotype
academic.oup.com
March 13, 2025 at 12:22 PM
Machine learning–driven immunophenotypic stratification of mixed connective tissue disease, corroborating the clinical heterogeneity
academic.oup.com/rheumatology...
academic.oup.com/rheumatology...
Happy New Year 🥳
Grateful to kick off 2025 with our research being featured. Thank you for sharing ✨
Grateful to kick off 2025 with our research being featured. Thank you for sharing ✨
Jan 2025 Arthritis & Rheumatology Clinical Connections
•Enhanced type I IFN signature in patients with axial spondyloarthritis unresponsive to secukinumab
•Muscle tissue transcriptome of idiopathic inflammatory myopathy reflects muscle damage process and presence of skin lesions
•Enhanced type I IFN signature in patients with axial spondyloarthritis unresponsive to secukinumab
•Muscle tissue transcriptome of idiopathic inflammatory myopathy reflects muscle damage process and presence of skin lesions
January 2, 2025 at 2:08 AM
Happy New Year 🥳
Grateful to kick off 2025 with our research being featured. Thank you for sharing ✨
Grateful to kick off 2025 with our research being featured. Thank you for sharing ✨
Autumn in Boston 🍂
November 20, 2024 at 7:09 PM
Autumn in Boston 🍂
Strolling in autumn. 🍂
November 10, 2024 at 10:45 AM
Strolling in autumn. 🍂
Reposted by Shinji Izuka
Looking to gather a list of all rheumatologists and rheumatology professionals!
Comment if I missed you!
#ACR24
#rheum
go.bsky.app/CEj2dcZ
Comment if I missed you!
#ACR24
#rheum
go.bsky.app/CEj2dcZ
November 7, 2024 at 5:50 PM
Looking to gather a list of all rheumatologists and rheumatology professionals!
Comment if I missed you!
#ACR24
#rheum
go.bsky.app/CEj2dcZ
Comment if I missed you!
#ACR24
#rheum
go.bsky.app/CEj2dcZ