Shawn Costello
@shawnmcostello.bsky.social
I like my proteins like I like my anxiety level, marginally stable and highly dynamic.
Postdoc in the Fordyce lab @ Stanford
Previously Biophysics in the Marqusee lab @ UC Berkeley
Postdoc in the Fordyce lab @ Stanford
Previously Biophysics in the Marqusee lab @ UC Berkeley
Reposted by Shawn Costello
Second, I’m slowly getting to be in the camp that proteins don’t have functions but instead have properties. What biology does with those properties is a somewhat different matter. So maybe we need to predict properties (kcat, Kd, etc) as well
October 15, 2025 at 2:58 PM
Second, I’m slowly getting to be in the camp that proteins don’t have functions but instead have properties. What biology does with those properties is a somewhat different matter. So maybe we need to predict properties (kcat, Kd, etc) as well
Reposted by Shawn Costello
This is great. A few additions. I suspect that what we really need is a model of macromolecular thermodynamics. Prediction potential alternative conformations is nice but unless we can assign weights it’s difficult to link to biology. Same for stability etc.
October 15, 2025 at 2:58 PM
This is great. A few additions. I suspect that what we really need is a model of macromolecular thermodynamics. Prediction potential alternative conformations is nice but unless we can assign weights it’s difficult to link to biology. Same for stability etc.
Reposted by Shawn Costello
When reporting on these kinds of claims, the media should ask:
September 7, 2025 at 11:14 AM
When reporting on these kinds of claims, the media should ask: