Liam Sharkey
@sharkeylkr.bsky.social
Bacteriologist at The Peter Doherty Institute, University of Melbourne
— 🧫 AMR, bacterial physiology, natural products, drug discovery.
— 🧫 AMR, bacterial physiology, natural products, drug discovery.
Reposted by Liam Sharkey
New from me, @mohammoud.bsky.social & Ruth in @aunz.theconversation.com - The government has pledged $10 million for inclusive LGBTQIA+ health care. Here's what that means
theconversation.com/the-governme...
theconversation.com/the-governme...
The government has pledged $10 million for inclusive LGBTQIA+ health care. Here’s what that means
‘Inclusive, culturally safe’ care for LGBTQIA+ patients means more than just rainbow posters in the waiting room.
theconversation.com
April 22, 2025 at 6:14 AM
New from me, @mohammoud.bsky.social & Ruth in @aunz.theconversation.com - The government has pledged $10 million for inclusive LGBTQIA+ health care. Here's what that means
theconversation.com/the-governme...
theconversation.com/the-governme...
Reposted by Liam Sharkey
I made a Starter Pack for the Staphylococcus community. Hope to find more good friends here on Bluesky to keep in touch about Staphylococcus infections, biology, microbiome interaction, antibiotic resistance and more. Please join and repost!
go.bsky.app/3zVWbSs
November 10, 2024 at 2:39 PM
I made a Starter Pack for the Staphylococcus community. Hope to find more good friends here on Bluesky to keep in touch about Staphylococcus infections, biology, microbiome interaction, antibiotic resistance and more. Please join and repost!
go.bsky.app/3zVWbSs
Reposted by Liam Sharkey
Our first foray into the world of Staph aureus superantigens lead by Linda Wakim. Some novel findings on T cell responsiveness post activation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Staphylococcal superantigens evoke temporary and reversible T cell anergy, but fail to block the development of a bacterium specific cellular immune response - Nature Communications
Bacterial superantigens (sAg) have been shown to induce T cell hyperactivation through cross linking between MHC class II on antigen presenting cells and certain TCRs on T lymphocytes. Here the author...
www.nature.com
November 19, 2024 at 10:37 AM
Our first foray into the world of Staph aureus superantigens lead by Linda Wakim. Some novel findings on T cell responsiveness post activation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Liam Sharkey
How’s that for parallel trends?
#dogsofeconsky
#dogsofeconsky
October 23, 2024 at 10:10 AM
How’s that for parallel trends?
#dogsofeconsky
#dogsofeconsky
Out today, Rifaximin drives cross resistance to Dapto.
www.nature.com/articles/s41...
Congratulations to the team behind this study! I can only find @clairegorrie.bsky.social on bsky.
www.nature.com/articles/s41...
Congratulations to the team behind this study! I can only find @clairegorrie.bsky.social on bsky.
Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin - Nature
Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.
www.nature.com
October 23, 2024 at 9:02 PM
Out today, Rifaximin drives cross resistance to Dapto.
www.nature.com/articles/s41...
Congratulations to the team behind this study! I can only find @clairegorrie.bsky.social on bsky.
www.nature.com/articles/s41...
Congratulations to the team behind this study! I can only find @clairegorrie.bsky.social on bsky.
Reposted by Liam Sharkey
Transcription activator-like effectors from endosymbiotic bacteria control the reproduction of their fungal host
mBio journal by Ingrid Richter et al from Hertweck Lab
journals.asm.org/doi/10.1128/...
mBio journal by Ingrid Richter et al from Hertweck Lab
journals.asm.org/doi/10.1128/...
November 16, 2023 at 8:12 PM
Transcription activator-like effectors from endosymbiotic bacteria control the reproduction of their fungal host
mBio journal by Ingrid Richter et al from Hertweck Lab
journals.asm.org/doi/10.1128/...
mBio journal by Ingrid Richter et al from Hertweck Lab
journals.asm.org/doi/10.1128/...
Reposted by Liam Sharkey
Here is some recent work we've been doing at Cultivarium on detecting methylation patterns with nanpore. We find that nanopore's modified basecalling models works well - if you have recently sequenced a prokaryotic isolate you can use MicrobeMod to ID methylation:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 15, 2023 at 1:45 PM
Here is some recent work we've been doing at Cultivarium on detecting methylation patterns with nanpore. We find that nanopore's modified basecalling models works well - if you have recently sequenced a prokaryotic isolate you can use MicrobeMod to ID methylation:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Liam Sharkey
Our latest paper is out now. The brilliant Chris Connor’s entire PhD in one paper. And I hope a new avenue of research opened in MDR E. coli
journals.plos.org/plosbiology/...
1/n
journals.plos.org/plosbiology/...
1/n
October 18, 2023 at 6:49 AM
Our latest paper is out now. The brilliant Chris Connor’s entire PhD in one paper. And I hope a new avenue of research opened in MDR E. coli
journals.plos.org/plosbiology/...
1/n
journals.plos.org/plosbiology/...
1/n
Did a big thread on Twitter, but will keep it short here.
We have a new paper out! If you're into signal transduction, staph aureus, and/or nifty molecular biology then check it out.
journals.asm.org/doi/10.1128/...
We have a new paper out! If you're into signal transduction, staph aureus, and/or nifty molecular biology then check it out.
journals.asm.org/doi/10.1128/...
The two-component system WalKR provides an essential link between cell wall homeostasis and DNA repl...
The opportunistic human pathogen Staphylococcus aureus uses an array of protein sensing systems called two-component systems (TCS) to sense
environmental signals and adapt its physiology in response b...
journals.asm.org
October 17, 2023 at 7:02 AM
Did a big thread on Twitter, but will keep it short here.
We have a new paper out! If you're into signal transduction, staph aureus, and/or nifty molecular biology then check it out.
journals.asm.org/doi/10.1128/...
We have a new paper out! If you're into signal transduction, staph aureus, and/or nifty molecular biology then check it out.
journals.asm.org/doi/10.1128/...
Reposted by Liam Sharkey
Protistan predation selects for antibiotic resistance in soil bacterial communities
-in ISME Journal
www.nature.com/articles/s41...
-in ISME Journal
www.nature.com/articles/s41...
October 4, 2023 at 7:07 PM
Protistan predation selects for antibiotic resistance in soil bacterial communities
-in ISME Journal
www.nature.com/articles/s41...
-in ISME Journal
www.nature.com/articles/s41...