Sebastian Gregoricchio, Ph.D.
@sgregoricchio.bsky.social
Postdoc in the Zwart lab at the Netherlands Cancer Institute (Amsterdam, Netherlands, @nkinl.bsky.social, @zwartlab.bsky.social). Studying gene regulation and 3D-genome organization in cancer.
X/Twitter: @s_gregoricchio
X/Twitter: @s_gregoricchio
Reposted by Sebastian Gregoricchio, Ph.D.
We all know that cancers -even from the same subtype- are highly heterogeneous right? In a new study we asked whether this was also the case for the three-dimensional organization of the genome in breast cancer. The answer: it’s complicated. www.cell.com/iscience/ful...
A 3D genome compendium of breast cancer progression
Genomics; Chromosome organization; Molecular Genetics; Cancer
www.cell.com
August 18, 2025 at 2:41 PM
We all know that cancers -even from the same subtype- are highly heterogeneous right? In a new study we asked whether this was also the case for the three-dimensional organization of the genome in breast cancer. The answer: it’s complicated. www.cell.com/iscience/ful...
Discover the role of #Zincore, a novel protein complex that acts as a co-regulator in activating DNA transcription by zinc finger transcription factors in this amazing work from @daaninthelab.bsky.social et al., now published in @science.org! Proud to have participated in this beautiful project!
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...
www.science.org
July 5, 2025 at 6:56 PM
Discover the role of #Zincore, a novel protein complex that acts as a co-regulator in activating DNA transcription by zinc finger transcription factors in this amazing work from @daaninthelab.bsky.social et al., now published in @science.org! Proud to have participated in this beautiful project!
Reposted by Sebastian Gregoricchio, Ph.D.
Now online in Cancer Discovery: Germline-Somatic Liaison Dictates Cancer Subtype via de novo Steroid Biosynthesis - by Paola Gasperini, Alessandro Alaimo, Blerta Stringa, Andrea Lunardi, Francesca Demichelis, and colleagues doi.org/10.1158/2159...
June 16, 2025 at 7:41 PM
Now online in Cancer Discovery: Germline-Somatic Liaison Dictates Cancer Subtype via de novo Steroid Biosynthesis - by Paola Gasperini, Alessandro Alaimo, Blerta Stringa, Andrea Lunardi, Francesca Demichelis, and colleagues doi.org/10.1158/2159...
Reposted by Sebastian Gregoricchio, Ph.D.
Check out our latest paper! Out now in Genome Biology! Many thanks to all coauthors for their invaluable contributions on this lengthy journey pubmed.ncbi.nlm.nih.gov/40346709/
Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations - PubMed
In summary, we identify a complex genomic-epigenomic interplay in EC development and progression, altering 3D genome organization to enhance expression of the critical driver ERα.
pubmed.ncbi.nlm.nih.gov
May 10, 2025 at 1:41 PM
Check out our latest paper! Out now in Genome Biology! Many thanks to all coauthors for their invaluable contributions on this lengthy journey pubmed.ncbi.nlm.nih.gov/40346709/
📢 Are you approaching the epigenetic world? Or you want to know more about ATAC-seq and it's applications?
In this case join the @oncodeinstitute.bsky.social workshop that will take place the 19th of September at the @nkinl.bsky.social !!
Places are limited to 35!! Subscribe at the following link:
In this case join the @oncodeinstitute.bsky.social workshop that will take place the 19th of September at the @nkinl.bsky.social !!
Places are limited to 35!! Subscribe at the following link:
Masterclass: ATAC-seq data analysis and applications | Oncode Institute
By Sebastian Gregoricchio (lab Wilbert Zwart, Netherlands Cancer Institute)
oncodeinstitute.nl
May 7, 2025 at 9:03 AM
📢 Are you approaching the epigenetic world? Or you want to know more about ATAC-seq and it's applications?
In this case join the @oncodeinstitute.bsky.social workshop that will take place the 19th of September at the @nkinl.bsky.social !!
Places are limited to 35!! Subscribe at the following link:
In this case join the @oncodeinstitute.bsky.social workshop that will take place the 19th of September at the @nkinl.bsky.social !!
Places are limited to 35!! Subscribe at the following link:
Reposted by Sebastian Gregoricchio, Ph.D.
TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination https://www.biorxiv.org/content/10.1101/2025.02.14.638236v1
February 17, 2025 at 2:16 PM
TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination https://www.biorxiv.org/content/10.1101/2025.02.14.638236v1
Reposted by Sebastian Gregoricchio, Ph.D.
Check out our latest preprint! Interested in Androgen Receptor, gene regulation and TRIM proteins? Well, in that case, I believe you’ll like this story!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination
The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number...
www.biorxiv.org
February 17, 2025 at 3:21 PM
Check out our latest preprint! Interested in Androgen Receptor, gene regulation and TRIM proteins? Well, in that case, I believe you’ll like this story!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...