Severin Lechner
@sevlechner.bsky.social
Induced Proximity, Epigenetics, Drug Discovery, Proteomics.
EMBO/MSCA postdoctoral fellow in Winter lab @ CeMM/AITHYRA
EMBO/MSCA postdoctoral fellow in Winter lab @ CeMM/AITHYRA
Reposted by Severin Lechner
New preprint: We isolate peptide–RNA photo-crosslinks with tunable RNA chains from living cells for mass spec. This maps over 4,700 crosslinking sites across 744 proteins and offers the first glimpse into the RNA sequences in crosslinks by MS. Read here: doi.org/10.1101/2025...
Peptide-RNA photo-crosslinks with tunable RNA chain map protein-RNA interfaces
Photo-crosslinking mass spectrometry enables the identification of protein-RNA interactions in living cells, pinpointing interaction interfaces at single-amino acid resolution. However, current isolat...
doi.org
September 9, 2025 at 11:46 AM
New preprint: We isolate peptide–RNA photo-crosslinks with tunable RNA chains from living cells for mass spec. This maps over 4,700 crosslinking sites across 744 proteins and offers the first glimpse into the RNA sequences in crosslinks by MS. Read here: doi.org/10.1101/2025...
Reposted by Severin Lechner
Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics!
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications
Protein function is dynamically modulated by post-translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. ...
doi.org
October 20, 2025 at 7:07 AM
Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics!
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
Reposted by Severin Lechner
They DecryptED all the KRAS small molecule inhibitors! Including cysteine enrichments! proteomicsnews.blogspot.com/2025/08/decr...
DeCrypt KRAS signaling using all the common inhbiitors!
This one had so many steps to get behind the paywall of that I thought I was trying to find a certain global leader's name thousands of ti...
proteomicsnews.blogspot.com
August 13, 2025 at 1:17 PM
They DecryptED all the KRAS small molecule inhibitors! Including cysteine enrichments! proteomicsnews.blogspot.com/2025/08/decr...
Reposted by Severin Lechner
Measuring & modeling nucleic acids is very useful and needed.
Yet, it provides a partial view.
It misses many biological processes, from signal transduction and metabolic fluxes, through enzyme activities to therapeutic effects.
bsky.app/profile/slav...
Yet, it provides a partial view.
It misses many biological processes, from signal transduction and metabolic fluxes, through enzyme activities to therapeutic effects.
bsky.app/profile/slav...
𝐀𝐫𝐞 𝐝𝐫𝐮𝐠 𝐞𝐟𝐟𝐞𝐜𝐭𝐬 𝐨𝐧 𝐦𝐑𝐍𝐀 𝐚𝐧𝐝 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐥𝐞𝐯𝐞𝐥𝐬 𝐬𝐢𝐦𝐢𝐥𝐚𝐫?
Below are example dose-response curves of drug-induced changes in protein (blue) and mRNA (pink) abundance.
1/n
Below are example dose-response curves of drug-induced changes in protein (blue) and mRNA (pink) abundance.
1/n
July 30, 2025 at 2:30 PM
Measuring & modeling nucleic acids is very useful and needed.
Yet, it provides a partial view.
It misses many biological processes, from signal transduction and metabolic fluxes, through enzyme activities to therapeutic effects.
bsky.app/profile/slav...
Yet, it provides a partial view.
It misses many biological processes, from signal transduction and metabolic fluxes, through enzyme activities to therapeutic effects.
bsky.app/profile/slav...
Reposted by Severin Lechner
@aithyra.bsky.social Opening Symposium "AI for Life Science" with Nobel Laureate Frances Arnold as keynote speaker in addition to an outstanding line up of speakers on a variety of topics across biological scales and data modalities.
Registration is now open at cemm.at/aithyra-symp...
Registration is now open at cemm.at/aithyra-symp...
July 24, 2025 at 7:26 PM
@aithyra.bsky.social Opening Symposium "AI for Life Science" with Nobel Laureate Frances Arnold as keynote speaker in addition to an outstanding line up of speakers on a variety of topics across biological scales and data modalities.
Registration is now open at cemm.at/aithyra-symp...
Registration is now open at cemm.at/aithyra-symp...
Reposted by Severin Lechner
🚨Our new paper is online🚨
We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics
www.cell.com/cell/fulltex...
We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics
www.cell.com/cell/fulltex...
The human proteome with direct physical access to DNA
Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living
cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale
of minutes with single-amino-aci...
www.cell.com
May 22, 2025 at 6:44 PM
🚨Our new paper is online🚨
We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics
www.cell.com/cell/fulltex...
We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics
www.cell.com/cell/fulltex...
Paper alert!
We report the first inhibitors for nucleoside kinases NME1-4 and for the nucleotide-binding protein HINT1.
On top, we provide probes for MBLAC2, an off-target of every second (!) hydroxamic acid-based HDAC inhibitor!
tinyurl.com/yh92vh6b
👇🧵
We report the first inhibitors for nucleoside kinases NME1-4 and for the nucleotide-binding protein HINT1.
On top, we provide probes for MBLAC2, an off-target of every second (!) hydroxamic acid-based HDAC inhibitor!
tinyurl.com/yh92vh6b
👇🧵
tinyurl.com
May 9, 2025 at 12:00 PM
Paper alert!
We report the first inhibitors for nucleoside kinases NME1-4 and for the nucleotide-binding protein HINT1.
On top, we provide probes for MBLAC2, an off-target of every second (!) hydroxamic acid-based HDAC inhibitor!
tinyurl.com/yh92vh6b
👇🧵
We report the first inhibitors for nucleoside kinases NME1-4 and for the nucleotide-binding protein HINT1.
On top, we provide probes for MBLAC2, an off-target of every second (!) hydroxamic acid-based HDAC inhibitor!
tinyurl.com/yh92vh6b
👇🧵
Reposted by Severin Lechner
One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last!
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics
Unifying the analysis of bottom-up proteomics data with CHIMERYS - Nature Methods
CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by...
doi.org
April 22, 2025 at 11:44 AM
One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last!
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics
Reposted by Severin Lechner
🚨 Hiring Alert – Senior Scientist (Biology) 🚨
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds
Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds
Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz
AITHYRA
www.oeaw.ac.at
April 7, 2025 at 12:52 PM
🚨 Hiring Alert – Senior Scientist (Biology) 🚨
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds
Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds
Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz
Reposted by Severin Lechner
🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...
Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...
www.biorxiv.org
March 21, 2025 at 4:17 AM
🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...
Reposted by Severin Lechner
Less than 3 weeks left⏳Register by April 7 for the #Ubiquitin & Friends Symposium, May 8-9, in beautiful Vienna!
Fantastic guest speakers, open slots for short talks, flash talks& posters: Great opportunity for students & #ECRs! Register soon to save your spot➡️ www.protein-degradation.org/symposium/
Fantastic guest speakers, open slots for short talks, flash talks& posters: Great opportunity for students & #ECRs! Register soon to save your spot➡️ www.protein-degradation.org/symposium/
March 18, 2025 at 1:56 PM
Less than 3 weeks left⏳Register by April 7 for the #Ubiquitin & Friends Symposium, May 8-9, in beautiful Vienna!
Fantastic guest speakers, open slots for short talks, flash talks& posters: Great opportunity for students & #ECRs! Register soon to save your spot➡️ www.protein-degradation.org/symposium/
Fantastic guest speakers, open slots for short talks, flash talks& posters: Great opportunity for students & #ECRs! Register soon to save your spot➡️ www.protein-degradation.org/symposium/
Reposted by Severin Lechner
Did you recently complete a ChemBio/MedChem PhD (non-UK) and are looking for the next challenge? I am seeking a prospective applicant for a Newton Fellowship with an exciting project in targeted protein dephosphorylation! Please reach out to e.devita@qmul.ac.uk
royalsociety.org/grants/newto...
royalsociety.org/grants/newto...
royalsociety.org
February 17, 2025 at 7:21 AM
Did you recently complete a ChemBio/MedChem PhD (non-UK) and are looking for the next challenge? I am seeking a prospective applicant for a Newton Fellowship with an exciting project in targeted protein dephosphorylation! Please reach out to e.devita@qmul.ac.uk
royalsociety.org/grants/newto...
royalsociety.org/grants/newto...
Reposted by Severin Lechner
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5