Sevgi Kostel Bal
@sevgikostelbal.bsky.social
Pediatric immunologist, Postdoctoral researcher @StAnna_CCRI, classics enthusiast #womeninSTEMI, She/her
🧵 Our latest study on long-term outcomes of bone marrow transplantation in NIK deficiency is now published in Frontiers in Immunology. Heartfelt thanks to all collaborators and to the dedicated team following these patients over 10 years. www.frontiersin.org/journals/imm...
Frontiers | Long-term outcome of bone marrow transplantation in NIK deficiency: non-redundant role of non-canonical NF-κB signaling in thymic reconstitution and secondary lymphoid organ development
IntroductionBiallelic mutations in MAP3K14, encoding NF-κB-inducing kinase (NIK), disrupt non-canonical NF-κB signaling and lead to a rare inborn error of im...
www.frontiersin.org
November 7, 2025 at 8:36 AM
🧵 Our latest study on long-term outcomes of bone marrow transplantation in NIK deficiency is now published in Frontiers in Immunology. Heartfelt thanks to all collaborators and to the dedicated team following these patients over 10 years. www.frontiersin.org/journals/imm...
Reposted by Sevgi Kostel Bal
How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
January 31, 2025 at 2:29 PM
How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Sevgi Kostel Bal
Reposted by Sevgi Kostel Bal
First they came for the immigrants, and I spoke out, because I’ve read the damn poem before and I know how it ends.
January 25, 2025 at 2:30 AM
First they came for the immigrants, and I spoke out, because I’ve read the damn poem before and I know how it ends.
Refusing vaccines has become the paragon embodiment of antimodernism. That’s why the conservatives appreciate the potential there and use it even more to bring in more votes from that new „cult“. No surprise RFK is nominated secretary of health.
As trust in medicine declines and vaccine hesitancy spreads, doctors are changing how they talk about lifesaving childhood shots.
Pediatricians Try New Tactics To Win Over Vaccine Skeptical Parents
As trust in medicine declines and vaccine hesitancy spreads, doctors are changing how they talk about lifesaving childhood shots.
www.nytimes.com
January 24, 2025 at 7:29 PM
Refusing vaccines has become the paragon embodiment of antimodernism. That’s why the conservatives appreciate the potential there and use it even more to bring in more votes from that new „cult“. No surprise RFK is nominated secretary of health.
Reposted by Sevgi Kostel Bal
15 December 1902 | Turkish Jewish woman, Victorine Sissa, was born in Constantinople. She emigrated to France.
She was deported to #Auschwitz from #Drancy on 28 September 1942. She did not survive.
She was deported to #Auschwitz from #Drancy on 28 September 1942. She did not survive.
December 15, 2024 at 12:00 PM
15 December 1902 | Turkish Jewish woman, Victorine Sissa, was born in Constantinople. She emigrated to France.
She was deported to #Auschwitz from #Drancy on 28 September 1942. She did not survive.
She was deported to #Auschwitz from #Drancy on 28 September 1942. She did not survive.
Reposted by Sevgi Kostel Bal
A new study this week showed how the most common blood test performed-—the CBC, complete blood count—contains a treasure chest of information that we are missing in reporting out to patients and doctors.
erictopol.substack.com/p/your-lab-t...
erictopol.substack.com/p/your-lab-t...
December 14, 2024 at 7:55 PM
A new study this week showed how the most common blood test performed-—the CBC, complete blood count—contains a treasure chest of information that we are missing in reporting out to patients and doctors.
erictopol.substack.com/p/your-lab-t...
erictopol.substack.com/p/your-lab-t...
Reposted by Sevgi Kostel Bal
Happy to announce the publication of our paper in Science Immunology. Here we describe the first patients with biallelic disease causing mutations in the LTBR gene encoding for the lymphotoxin beta receptor. 1/10
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation
Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.
www.science.org
November 25, 2024 at 11:56 AM
Happy to announce the publication of our paper in Science Immunology. Here we describe the first patients with biallelic disease causing mutations in the LTBR gene encoding for the lymphotoxin beta receptor. 1/10
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sevgi Kostel Bal
Sectarianism in immunology.
(highly specific for immunologists, all credit to @pedromics on X)
1/8
(highly specific for immunologists, all credit to @pedromics on X)
1/8
November 25, 2024 at 7:35 PM
Sectarianism in immunology.
(highly specific for immunologists, all credit to @pedromics on X)
1/8
(highly specific for immunologists, all credit to @pedromics on X)
1/8
Reposted by Sevgi Kostel Bal
Tertiary lymphoid structure as a therapeutic target of Crohns disease: modulation by TNFα blockade https://www.biorxiv.org/content/10.1101/2024.11.23.625032v1
Tertiary lymphoid structure as a therapeutic target of Crohns disease: modulation by TNFα blockade https://www.biorxiv.org/content/10.1101/2024.11.23.625032v1
Inflammatory diseases, such as Crohn's disease (CD), are primarily treated with therapies aimed at a
www.biorxiv.org
November 26, 2024 at 1:16 AM
Tertiary lymphoid structure as a therapeutic target of Crohns disease: modulation by TNFα blockade https://www.biorxiv.org/content/10.1101/2024.11.23.625032v1
Reposted by Sevgi Kostel Bal
Here is the pdf:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2024 at 5:38 PM
Here is the pdf:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sevgi Kostel Bal
New in #ScienceImmunology:
Research from @boztugk.bsky.social and team identifies an inborn error of #immunity caused by human LTβR deficiency, resulting in defective stromal cell signaling and impaired humoral immune responses.
Read more: www.science.org/doi/10.1126/...
Research from @boztugk.bsky.social and team identifies an inborn error of #immunity caused by human LTβR deficiency, resulting in defective stromal cell signaling and impaired humoral immune responses.
Read more: www.science.org/doi/10.1126/...
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation
Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.
www.science.org
November 23, 2024 at 8:53 AM
New in #ScienceImmunology:
Research from @boztugk.bsky.social and team identifies an inborn error of #immunity caused by human LTβR deficiency, resulting in defective stromal cell signaling and impaired humoral immune responses.
Read more: www.science.org/doi/10.1126/...
Research from @boztugk.bsky.social and team identifies an inborn error of #immunity caused by human LTβR deficiency, resulting in defective stromal cell signaling and impaired humoral immune responses.
Read more: www.science.org/doi/10.1126/...
Congratulations to the whole team @stanna-ccri.bsky.social, and heartfelt thanks to everyone involved, including the patients and collaborators.
So my first post for the project I have worked all through my time in Vienna. It has been an amazing journey to delve into the lymph nodes & NFKB. Bernhard Ransmayr has done a great job to shape the whole story and I have proudly witnessed his growing in the process!! www.science.org/doi/10.1126/...
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation
Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.
www.science.org
November 23, 2024 at 9:34 AM
Congratulations to the whole team @stanna-ccri.bsky.social, and heartfelt thanks to everyone involved, including the patients and collaborators.
So my first post for the project I have worked all through my time in Vienna. It has been an amazing journey to delve into the lymph nodes & NFKB. Bernhard Ransmayr has done a great job to shape the whole story and I have proudly witnessed his growing in the process!! www.science.org/doi/10.1126/...
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation
Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.
www.science.org
November 23, 2024 at 9:26 AM
So my first post for the project I have worked all through my time in Vienna. It has been an amazing journey to delve into the lymph nodes & NFKB. Bernhard Ransmayr has done a great job to shape the whole story and I have proudly witnessed his growing in the process!! www.science.org/doi/10.1126/...
Reposted by Sevgi Kostel Bal
Truly cannot think of a greater achievement, or a greater sorrow when that fell through decades later
November 16, 2024 at 6:59 AM
Truly cannot think of a greater achievement, or a greater sorrow when that fell through decades later