We demonstrated that testing was feasible and about 25% of recurrent tumors had variants in cancer predisposition genes of which 20% were germline. Rapid reflex germline testing of tumor results is warranted.

Appreciate it.

I’m scheduled for a late November study section but they haven’t given us our review assignments. Anyone know the minimum time to review is required.

Totally agree on how hard it is to get reviewers for many journals.

Arrived at 11:00pm

Will you be at the Baylor party?

Nicky - on an 8 hour delayed flight but happy to talk at ASHG about new guidelines.

Interested in this point. If it does a task the suggested prompts are often - make it better or change tone. That suggests to the user that it can evaluate its own response. Is that not true?

I’m a child of a German Jewish family that escaped in 1939 - growing up in Philadelphia I remember reading many times over a book about how Denmark saved their Jewish population in boats to Sweden. It was very important to have that one story of a country which didn’t allow the massacre to occur.

Is there a way to download this thread (like in Twitter) as I would love to she with some AI believer colleagues.

Excited to have an entire session on different aspects of germline and somatic cancer curation in ClinGen - clinicalgenome.org today at the Cancer Genomics Consortium annual meeting in Houston. #CGCAnnual2025

Agree - I was thinking that is a lot of walking

Appreciated the long thread. It seems so dependent on having a health system ready to use the data in a rational way. Likely much more true in the UK than US where the baby with genome data would then wind up in our chaotic healthcare system (or potentially uninsured).

In US we have had students work with all of us data.

The policy includes submitting to Pubmed central without an embargo. You are not required to pay for Open Access.

This is actually a topic that was talked about quite a bit in the good days of science Twitter. Many people noted that if a reviewer or interviewer sees the publication and then sees your CV they may not be accustomed to the change in order.

It will be an individual decision. As a type 1 diabetic 25 years and a physician - dying from overwhelming infection worries me. Also we have no idea how long the cells will last - 10 people lasted >1 yr. Not sure I would want to face going back when they fail.

Great step forward but requires long term immunosuppression. Very difficult trade-off.