We found saliva-blood cross-tissue ICCs were mostly moderate for 2nd/3rd gen clocks and DNAm of physiology and Epigenetic-g. PCGrimAge (r=0.76) was highest, then PCPhenoAge (r=0.72) and Epigenetic-g (r=0.69). 1st gen clock acceleration showed poor similarity.

We pooled data from 3 studies with saliva 🧪 and blood 🩸 DNAm (n=107). In each tissue, we computed 3 generations of epigenetic clocks and DNAm measures of CRP, BMI, and cognition (epigenetic-g), adjusting for cell count variation, as we do in our saliva studies