Sergiu Groppa
@segroppa.bsky.social
Professor and Director of #Neurology, Saarland University, Germany
www.uks.eu/neurologie
www.uks.eu/neurologie
We link pathological brain activity in PD with distinct signatures in #microglia, #oligodendrocytes and #OPC states and to specific mechanisms of abnormal protein folding, mitochondrial dysfunction and brain immunology in PD for future trials
bit.ly/3IoRFoP
bit.ly/3IoRFoP
Cortical Single-Cell Primers of Abnormal Brain Activity in Parkinson’s Disease | Research
Abnormal brain oscillatory activity is a well-established hallmark of bradykinesia and motor impairment in Parkinson’s disease (PD), yet its molecular underpinnings remain unclear. To address this gap...
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September 14, 2025 at 2:39 PM
We link pathological brain activity in PD with distinct signatures in #microglia, #oligodendrocytes and #OPC states and to specific mechanisms of abnormal protein folding, mitochondrial dysfunction and brain immunology in PD for future trials
bit.ly/3IoRFoP
bit.ly/3IoRFoP
Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh
shorturl.at/5Atjh
Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo
Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson’s disease; howe
shorturl.at
June 10, 2025 at 6:47 PM
Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh
shorturl.at/5Atjh
Quantifying neurodegeneration is challenging, but a key prerequisite to modify disease courses. In this new review we discuss the opportunieties of structural covariance #imaging for tracking #neurodegenerative disorders.
#Neurology
#MultipleSclerosis
#ParkinsonsDisease
bit.ly/4j7lR4c
#Neurology
#MultipleSclerosis
#ParkinsonsDisease
bit.ly/4j7lR4c
Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders
Standard MRI focuses on brain structure but may not fully capture disease progression. Mongay-Ochoa et al. review advanced methods for mapping brain connec
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May 18, 2025 at 6:22 PM
Quantifying neurodegeneration is challenging, but a key prerequisite to modify disease courses. In this new review we discuss the opportunieties of structural covariance #imaging for tracking #neurodegenerative disorders.
#Neurology
#MultipleSclerosis
#ParkinsonsDisease
bit.ly/4j7lR4c
#Neurology
#MultipleSclerosis
#ParkinsonsDisease
bit.ly/4j7lR4c
#Glycosphingolipidomics alterations iincluding #peripheral #immunity dependant profiles in #Parkinsons disease New Manuscript allert in #NatComm go.nature.com/43AalJZ
#Neurology
#Medicine
#Neurology
#Medicine
Extended coverage of human serum glycosphingolipidome by 4D-RP-LC TIMS-PASEF unravels association with Parkinson’s disease - Nature Communications
4D-TIMS-glycosphingolipidomics expedite clinical serum profiling of 376 GSLs covering ganglio- and neolacto-series, neutrals and sulfatides. Clinical phenotyping of Parkinson’s disease cohort (sub)gro...
go.nature.com
May 17, 2025 at 12:24 PM
#Glycosphingolipidomics alterations iincluding #peripheral #immunity dependant profiles in #Parkinsons disease New Manuscript allert in #NatComm go.nature.com/43AalJZ
#Neurology
#Medicine
#Neurology
#Medicine
Happy to share our new work on cortical sc scRNA profiles in #Parkinsons Disease. We see abnormal #microglia and #oligodendrocytes progenitors,modified mitochondrial function, energy consumption and altered immune activation.Huge basis for new therapeutic pathways development.
go.nature.com/3WgDIwR
go.nature.com/3WgDIwR
Targeting pathological brain activity-related to neuroinflammation through scRNA-seq for new personalized therapies in Parkinson’s disease - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Targeting pathological brain activity-related to neuroinflammation through scRNA-seq for new personalized therapies in Parkinson’s disease
go.nature.com
January 11, 2025 at 2:33 PM
Happy to share our new work on cortical sc scRNA profiles in #Parkinsons Disease. We see abnormal #microglia and #oligodendrocytes progenitors,modified mitochondrial function, energy consumption and altered immune activation.Huge basis for new therapeutic pathways development.
go.nature.com/3WgDIwR
go.nature.com/3WgDIwR
Enhancing declarative memory in #PD patients by sleep stage specific adaptation of #DBS frequency. A milestone for patients and future neurostimulation algorithms to modulate memory bit.ly/4fu9rCp
Low‐Frequency Deep Brain Stimulation in Non‐Rapid Eye Movement Sleep Modifies Memory Retention in Parkinson's Disease
Background and Objective Memory impairment is a frequent and debilitating symptom in neurodegenerative disorders. The objective of this study was to provide proof-of-principle that deep brain stimul...
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November 21, 2024 at 6:33 PM
Enhancing declarative memory in #PD patients by sleep stage specific adaptation of #DBS frequency. A milestone for patients and future neurostimulation algorithms to modulate memory bit.ly/4fu9rCp
Captivating review on control of actions, adaptive, goal-directed behaviours and impulsive traits with an emphasis on the modulatory role of basal ganglia and subthalamic nucleus
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinson’s disease
Herz et al. review recent studies that have used deep brain stimulation electrodes to record neural activity from, or apply electrical stimulation to, the
academic.oup.com
October 24, 2024 at 9:09 AM
Captivating review on control of actions, adaptive, goal-directed behaviours and impulsive traits with an emphasis on the modulatory role of basal ganglia and subthalamic nucleus
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Similar morphometric brain alterations in patients with #multiplesclerosis and #depression. Read our latest work
bit.ly/3QZpnCw
bit.ly/3QZpnCw
Concurrent inflammation-related brain reorganization in multiple sclerosis and depression
Neuroinflammation affects brain tissue integrity in multiple sclerosis (MS) and may have a role in major depressive disorder (MDD). Whether advanced m…
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May 25, 2024 at 10:38 AM
Similar morphometric brain alterations in patients with #multiplesclerosis and #depression. Read our latest work
bit.ly/3QZpnCw
bit.ly/3QZpnCw
Comprehensive Review on the use of advanced therapies in #Parkinsons disease bit.ly/3UjACrk
Advanced therapies in Parkinson’s disease: an individualized approach to their indication - Journal of Neural Transmission
Device aided therapies (DAT) comprising the intrajejunal administration of levodopa/carbidopa intestinal gel (LCIG) and levodopa/carbidopa/entacapone intestinal gel (LECIG), the continuous subcutaneou...
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April 18, 2024 at 3:37 AM
Comprehensive Review on the use of advanced therapies in #Parkinsons disease bit.ly/3UjACrk
Excited to share our new work on motor control in patients with #ParkinsonsDisease-continous and online analysis of brain activity& adaptation of deep brain stimulation in dependancy of the performed movements led to an improved motor control in PD.Important next step for #DBS.
go.nature.com/49vO005
go.nature.com/49vO005
Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control - Nature Communications
How movement speed is neurally modulated remains poorly understood. Here, the authors recorded invasive brain signals in Parkinson’s disease patients during drawing and deep brain stimulation, showing...
go.nature.com
April 13, 2024 at 8:34 PM
Excited to share our new work on motor control in patients with #ParkinsonsDisease-continous and online analysis of brain activity& adaptation of deep brain stimulation in dependancy of the performed movements led to an improved motor control in PD.Important next step for #DBS.
go.nature.com/49vO005
go.nature.com/49vO005
Major heterogeneity of the classical neurological disorders with a strong need of biological definitions and phenotype characterisations: important step for #multiplesclerosis research and future therapies - imaging, immune states & clinics for distinct phenotypes: bit.ly/3U6RT7j
Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories
Three discrete immunological endophenotypes in early multiple sclerosis correlate with distinct disease trajectories and treatment responses.
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March 29, 2024 at 2:14 PM
Major heterogeneity of the classical neurological disorders with a strong need of biological definitions and phenotype characterisations: important step for #multiplesclerosis research and future therapies - imaging, immune states & clinics for distinct phenotypes: bit.ly/3U6RT7j
#Tremor is one of the most debilitating symptoms in #Parkinson disease. See our new work, that dissects by the aid of advanced electrophysiology fascinating new insights on tremor generators in #PD and how L-Dopa alleviates tremor. Relevant work for improved future treatments!
bit.ly/43zo3vc
bit.ly/43zo3vc
March 27, 2024 at 6:28 PM
#Tremor is one of the most debilitating symptoms in #Parkinson disease. See our new work, that dissects by the aid of advanced electrophysiology fascinating new insights on tremor generators in #PD and how L-Dopa alleviates tremor. Relevant work for improved future treatments!
bit.ly/43zo3vc
bit.ly/43zo3vc
See our new work on stroke imaging with an advanced deep learning augmented protocol and highly accelerated scanning time
bit.ly/4c78gaE
bit.ly/4c78gaE
Ultrafast Brain MRI with Deep Learning Reconstruction for Suspected Acute Ischemic Stroke
Background Deep learning (DL)–accelerated MRI can substantially reduce examination times. However, studies prospectively evaluating the diagnostic performance of DL-accelerated MRI reconstructions in ...
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March 6, 2024 at 8:34 PM
See our new work on stroke imaging with an advanced deep learning augmented protocol and highly accelerated scanning time
bit.ly/4c78gaE
bit.ly/4c78gaE