Séb Wielgoss
@sebwielgoss.bsky.social
Senior Scientist, Microbiologist
Reposted by Séb Wielgoss
Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
Resistance to last-resort antibiotics in enterococci
Abstract. The genus Enterococcus comprises a diverse group of species, many of which are commensal members of the gut microbiota of humans and animals. The
academic.oup.com
November 8, 2025 at 5:41 PM
Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
academic.oup.com/femsre/advan... (accepted manuscript version)
TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
Reposted by Séb Wielgoss
Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides.
Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...
Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...
November 6, 2025 at 5:00 AM
Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides.
Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...
Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...
Reposted by Séb Wielgoss
Love the idea of the "deletion test" posed by @needhibhalla.bsky.social & coauthors in their commentary about costs of cutting DEI efforts in science.
What if that student were "deleted?" What will the costs be?
Screenshots attached to enhance access. www.nature.com/articles/s41...
What if that student were "deleted?" What will the costs be?
Screenshots attached to enhance access. www.nature.com/articles/s41...
November 5, 2025 at 8:49 PM
Love the idea of the "deletion test" posed by @needhibhalla.bsky.social & coauthors in their commentary about costs of cutting DEI efforts in science.
What if that student were "deleted?" What will the costs be?
Screenshots attached to enhance access. www.nature.com/articles/s41...
What if that student were "deleted?" What will the costs be?
Screenshots attached to enhance access. www.nature.com/articles/s41...
Reposted by Séb Wielgoss
The 2025 state of the climate report: a planet on the brink
https://doi.org/10.1093/biosci/biaf149
#climatechange #climatescience
https://doi.org/10.1093/biosci/biaf149
#climatechange #climatescience
November 6, 2025 at 3:26 PM
The 2025 state of the climate report: a planet on the brink
https://doi.org/10.1093/biosci/biaf149
#climatechange #climatescience
https://doi.org/10.1093/biosci/biaf149
#climatechange #climatescience
Reposted by Séb Wielgoss
Interesting paper
'Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019'
TL;DR:
- dramatic falls in MRSA
- pneumococcal resistance rates low
- E. faecium more prevalent (and more vanR) than E. faecalis
pubmed.ncbi.nlm.nih.gov/41140273/
'Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019'
TL;DR:
- dramatic falls in MRSA
- pneumococcal resistance rates low
- E. faecium more prevalent (and more vanR) than E. faecalis
pubmed.ncbi.nlm.nih.gov/41140273/
Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019 - PubMed
Gram-positive pathogens were the dominant historical pathogens of bacteraemia. The trends seen here-with many near-universally active antibiotics-indicate little hazard of this situation returning. Nevertheless, few treatments exist in some settings, notably multi-resistant E. faecium endocarditis.
pubmed.ncbi.nlm.nih.gov
October 28, 2025 at 10:17 AM
Interesting paper
'Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019'
TL;DR:
- dramatic falls in MRSA
- pneumococcal resistance rates low
- E. faecium more prevalent (and more vanR) than E. faecalis
pubmed.ncbi.nlm.nih.gov/41140273/
'Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019'
TL;DR:
- dramatic falls in MRSA
- pneumococcal resistance rates low
- E. faecium more prevalent (and more vanR) than E. faecalis
pubmed.ncbi.nlm.nih.gov/41140273/
Reposted by Séb Wielgoss
Interesting paper on bacteriophage genomics and bioinformatics
'Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world' by @sebwielgoss.bsky.social and colleagues
academic.oup.com/bib/article/...
'Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world' by @sebwielgoss.bsky.social and colleagues
academic.oup.com/bib/article/...
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio
academic.oup.com
October 21, 2025 at 1:45 PM
Interesting paper on bacteriophage genomics and bioinformatics
'Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world' by @sebwielgoss.bsky.social and colleagues
academic.oup.com/bib/article/...
'Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world' by @sebwielgoss.bsky.social and colleagues
academic.oup.com/bib/article/...
Reposted by Séb Wielgoss
Professor (full) or Associate Professor (tenure track) in Microbial Genetics of Health (U. Turku Finland). Competitive starting package included! Please share.
duunitori.fi/tyopaikat/ty...
duunitori.fi/tyopaikat/ty...
Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto - Työpaikat - Duunitori
Avoin työpaikka: Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto, Turku. Duunitorilla lisäksi yli 30 000 muuta avointa työpaikkaa. Lue lisää nyt!
duunitori.fi
September 30, 2025 at 8:37 AM
Professor (full) or Associate Professor (tenure track) in Microbial Genetics of Health (U. Turku Finland). Competitive starting package included! Please share.
duunitori.fi/tyopaikat/ty...
duunitori.fi/tyopaikat/ty...
Reposted by Séb Wielgoss
Cool PNAS paper by @jordivangestel.bsky.social and colleagues
Contributed by Carol Gross
[reviewed by @polzlab.bsky.social and @wcratcliff.bsky.social]
Bacillus subtilis in defense mode: Switch-like adaptations to protistan predation
www.pnas.org/doi/10.1073/...
Contributed by Carol Gross
[reviewed by @polzlab.bsky.social and @wcratcliff.bsky.social]
Bacillus subtilis in defense mode: Switch-like adaptations to protistan predation
www.pnas.org/doi/10.1073/...
September 25, 2025 at 6:29 PM
Cool PNAS paper by @jordivangestel.bsky.social and colleagues
Contributed by Carol Gross
[reviewed by @polzlab.bsky.social and @wcratcliff.bsky.social]
Bacillus subtilis in defense mode: Switch-like adaptations to protistan predation
www.pnas.org/doi/10.1073/...
Contributed by Carol Gross
[reviewed by @polzlab.bsky.social and @wcratcliff.bsky.social]
Bacillus subtilis in defense mode: Switch-like adaptations to protistan predation
www.pnas.org/doi/10.1073/...
Reposted by Séb Wielgoss
New paper alert! We suggest caution in the analyses of viral auxiliary metabolic genes and propose a new overarching term - 'auxiliary viral genes' (AVGs) to describe different types of such genes. @simrouxvirus.bsky.social #phagesky #Microsky www.nature.com/articles/s41...
A call for caution in the biological interpretation of viral auxiliary metabolic genes - Nature Microbiology
This Perspective discusses virus-encoded auxiliary metabolic genes and provides a framework for the biological interpretation of these genes.
www.nature.com
August 27, 2025 at 12:24 PM
New paper alert! We suggest caution in the analyses of viral auxiliary metabolic genes and propose a new overarching term - 'auxiliary viral genes' (AVGs) to describe different types of such genes. @simrouxvirus.bsky.social #phagesky #Microsky www.nature.com/articles/s41...
Reposted by Séb Wielgoss
Longstanding collaboration with Scott Manalis where we have developed technology to measure single cell growth rates of bacteria in native seawater with some very surprising results.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 11, 2025 at 4:56 PM
Longstanding collaboration with Scott Manalis where we have developed technology to measure single cell growth rates of bacteria in native seawater with some very surprising results.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Séb Wielgoss
Genome evolution of Acinetobacter baylyi ADP1 during laboratory domestication: acquired mutations impact competence and metabolism
#ApplEnvironMicrobiol from Jeff Barrick
journals.asm.org/doi/10.1128/...
#ApplEnvironMicrobiol from Jeff Barrick
journals.asm.org/doi/10.1128/...
Genome evolution of Acinetobacter baylyi ADP1 during laboratory domestication: acquired mutations impact competence and metabolism | Applied and Environmental Microbiology
Acinetobacter baylyi ADP1 is a bacterial chassis of interest to microbiologists in academia and industry
due to its extreme natural competence and wide metabolic range. Its ability to take
up DNA from...
journals.asm.org
September 18, 2025 at 11:14 AM
Genome evolution of Acinetobacter baylyi ADP1 during laboratory domestication: acquired mutations impact competence and metabolism
#ApplEnvironMicrobiol from Jeff Barrick
journals.asm.org/doi/10.1128/...
#ApplEnvironMicrobiol from Jeff Barrick
journals.asm.org/doi/10.1128/...
Reposted by Séb Wielgoss
very cool work and a milestone in synthetic biology. how impressive are the new phage genomes?
with generative bioML, i'm always looking at how similar the generated sequences are to known sequences. let's take a look
with generative bioML, i'm always looking at how similar the generated sequences are to known sequences. let's take a look
Many of the most complex and useful functions in biology emerge at the scale of whole genomes.
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
September 18, 2025 at 3:30 AM
very cool work and a milestone in synthetic biology. how impressive are the new phage genomes?
with generative bioML, i'm always looking at how similar the generated sequences are to known sequences. let's take a look
with generative bioML, i'm always looking at how similar the generated sequences are to known sequences. let's take a look
Reposted by Séb Wielgoss
Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes.
@nfrk92.bsky.social
@narjournal.bsky.social
academic.oup.com/nar/article/...
@nfrk92.bsky.social
@narjournal.bsky.social
academic.oup.com/nar/article/...
Exclusion systems preserve host cell homeostasis and fitness, ensuring successful dissemination of conjugative plasmids and associated resistance genes
Abstract. Plasmid conjugation is a major driver of antibiotic resistance dissemination in bacteria. In addition to genes required for transfer and maintena
academic.oup.com
September 17, 2025 at 10:17 AM
Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes.
@nfrk92.bsky.social
@narjournal.bsky.social
academic.oup.com/nar/article/...
@nfrk92.bsky.social
@narjournal.bsky.social
academic.oup.com/nar/article/...
Reposted by Séb Wielgoss
Mittwoch! Passend zur Sommerszeit: eine kleine Geschichte der Sonnenbrille. Wir sprechen nicht nur über ihre Anfänge, sondern vor allem über die Bedeutung, die sie im Laufe ihrer Geschichte erhalten hat.
https://www.geschichte.fm/archiv/gag512/
https://www.geschichte.fm/archiv/gag512/
GAG512: Eine kleine Geschichte der Sonnenbrille - Geschichten aus der Geschichte
Eine Geschichte über Sonnenschutz, Identität und Rebellion
www.geschichte.fm
July 16, 2025 at 8:01 AM
Mittwoch! Passend zur Sommerszeit: eine kleine Geschichte der Sonnenbrille. Wir sprechen nicht nur über ihre Anfänge, sondern vor allem über die Bedeutung, die sie im Laufe ihrer Geschichte erhalten hat.
https://www.geschichte.fm/archiv/gag512/
https://www.geschichte.fm/archiv/gag512/
Reposted by Séb Wielgoss
"Overall, the message from this survey is positive– #evolutionary #biologists are readily employable outside of #academia, generally well-prepared for those jobs, and report high levels of satisfaction in their non-academic #careers"
https://www.biorxiv.org/content/10.1101/2025.08.19.671061v1
https://www.biorxiv.org/content/10.1101/2025.08.19.671061v1
September 15, 2025 at 9:06 PM
"Overall, the message from this survey is positive– #evolutionary #biologists are readily employable outside of #academia, generally well-prepared for those jobs, and report high levels of satisfaction in their non-academic #careers"
https://www.biorxiv.org/content/10.1101/2025.08.19.671061v1
https://www.biorxiv.org/content/10.1101/2025.08.19.671061v1
Need advice on which of the many virus 🦠 prediction tools to apply for your phage research🔎?
This guide equips you for your bioinformatic analyses in your
"quest to explore the genetic diversity and biology of the smallest and most abundant replicators on Earth."
⬇️
doi.org/10.1093/bib/...
This guide equips you for your bioinformatic analyses in your
"quest to explore the genetic diversity and biology of the smallest and most abundant replicators on Earth."
⬇️
doi.org/10.1093/bib/...
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio
doi.org
September 12, 2025 at 9:38 AM
Need advice on which of the many virus 🦠 prediction tools to apply for your phage research🔎?
This guide equips you for your bioinformatic analyses in your
"quest to explore the genetic diversity and biology of the smallest and most abundant replicators on Earth."
⬇️
doi.org/10.1093/bib/...
This guide equips you for your bioinformatic analyses in your
"quest to explore the genetic diversity and biology of the smallest and most abundant replicators on Earth."
⬇️
doi.org/10.1093/bib/...
Reposted by Séb Wielgoss
Excited to share new #program, STEPS, which can simulate #dynamics of the E. coli Long-Term Evolution Experiment (#LTEE) or other microbes in serial transfer regime.
telliamedrevisited.wordpress.com/2025/08/12/s...
STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.
telliamedrevisited.wordpress.com/2025/08/12/s...
STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.
STEPS To It
Announcing a new program, called STEPS, to simulate the dynamics of evolving microbial populations.
telliamedrevisited.wordpress.com
August 12, 2025 at 3:53 PM
Excited to share new #program, STEPS, which can simulate #dynamics of the E. coli Long-Term Evolution Experiment (#LTEE) or other microbes in serial transfer regime.
telliamedrevisited.wordpress.com/2025/08/12/s...
STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.
telliamedrevisited.wordpress.com/2025/08/12/s...
STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.
Reposted by Séb Wielgoss
Interested in exploring prophages in your (meta)genomes, but don't know how and where to start? We've put together a beginners guide to exploring viral diversity in prokaryotes @marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
Our new review is out in
Briefings in Bioinformatics
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
@ccwendling.bsky.social
@marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
doi.org/10.1093/bib/...
Briefings in Bioinformatics
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
@ccwendling.bsky.social
@marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
doi.org/10.1093/bib/...
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio
doi.org
September 4, 2025 at 3:15 PM
Interested in exploring prophages in your (meta)genomes, but don't know how and where to start? We've put together a beginners guide to exploring viral diversity in prokaryotes @marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
Our new review is out in
Briefings in Bioinformatics
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
@ccwendling.bsky.social
@marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
doi.org/10.1093/bib/...
Briefings in Bioinformatics
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
@ccwendling.bsky.social
@marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
doi.org/10.1093/bib/...
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio
doi.org
September 4, 2025 at 3:13 PM
Our new review is out in
Briefings in Bioinformatics
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
@ccwendling.bsky.social
@marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
doi.org/10.1093/bib/...
Briefings in Bioinformatics
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
@ccwendling.bsky.social
@marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
doi.org/10.1093/bib/...