Sebastian Oehm
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Sebastian Oehm
@sebastianoehm.bsky.social
69 followers 29 following 18 posts
Synthetic biology, biosecurity, therapeutics
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sebastianoehm.bsky.social
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
www.nature.com/articles/s41...
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion - Nature Chemistry
Negatively charged lysine acylations—malonylation, succinylation and glutarylation—impact protein structure and function, which can affect cellular processes. Now temporarily masked thioester derivati...
www.nature.com
April 1, 2024 at 1:25 PM
sebastianoehm.bsky.social
Expanding the molecular language of protein liquid–liquid phase separation
www.nature.com/articles/s41...
Expanding the molecular language of protein liquid–liquid phase separation - Nature Chemistry
Key molecular features that drive protein liquid–liquid phase separation (LLPS) for biomolecular condensate have been reported. A spectrum of additional interactions that influence protein LLPS and ma...
www.nature.com
April 1, 2024 at 1:25 PM
sebastianoehm.bsky.social
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
www.nature.com/articles/s41...
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA - Nature Biotechnology
mRNA with engineered poly(A) tails produces prolonged higher levels of protein.
www.nature.com
April 1, 2024 at 1:24 PM
sebastianoehm.bsky.social
Oncolytic mineralized bacteria as potent locally administered immunotherapeutics
www.nature.com/articles/s41...
Oncolytic mineralized bacteria as potent locally administered immunotherapeutics - Nature Biomedical Engineering
Intratumourally administered bacteria coated with manganese dioxide modulate the immunosuppressive tumour microenvironment and potently activate antitumour immune responses, as shown in multiple solid...
www.nature.com
April 1, 2024 at 1:24 PM
sebastianoehm.bsky.social
Evolution-guided engineering of trans-acyltransferase polyketide synthases www.science.org/doi/10.1126/...
Evolution-guided engineering of trans-acyltransferase polyketide synthases
Single-molecular tension sensors reveal cellular force loading rate during mechanotransduction.
www.science.org
April 1, 2024 at 1:24 PM
sebastianoehm.bsky.social
Generalized biomolecular modeling and design with RoseTTAFold All-Atom www.science.org/doi/10.1126/...
Generalized biomolecular modeling and design with RoseTTAFold All-Atom
Deep learning methods have revolutionized protein structure prediction and design but are currently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA) which combines a residue-ba...
www.science.org
April 1, 2024 at 1:23 PM
sebastianoehm.bsky.social
Efficient formation of single-copy human artificial chromosomes www.science.org/doi/10.1126/...
April 1, 2024 at 1:23 PM
sebastianoehm.bsky.social
Self-driving laboratories to autonomously navigate the protein fitness landscape

www.nature.com/articles/s44...
Self-driving laboratories to autonomously navigate the protein fitness landscape - Nature Chemical E...
Protein engineering is a powerful tool to create new proteins with useful functions and behaviors, but it is slow, laborious and requires specialized knowledge, limiting its broad application. Here, t...
www.nature.com
February 1, 2024 at 10:50 AM
sebastianoehm.bsky.social
An adenine base editor variant expands context compatibility

www.nature.com/articles/s41...
An adenine base editor variant expands context compatibility - Nature Biotechnology
An improved adenine base editor corrects clinically relevant mutations inaccessible to current editors.
www.nature.com
February 1, 2024 at 10:50 AM
sebastianoehm.bsky.social
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution

www.nature.com/articles/s41...
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellul...
Computationally designed sensors map the activity and signaling environment of Ras.
www.nature.com
February 1, 2024 at 10:49 AM
sebastianoehm.bsky.social
Prime editing using CRISPR-Cas12a and circular RNAs in human cells

www.nature.com/articles/s41...
Prime editing using CRISPR-Cas12a and circular RNAs in human cells - Nature Biotechnology
Prime editing with CRISPR-Cas12a broadens targeting scope and enables multiplexing.
www.nature.com
February 1, 2024 at 10:49 AM
sebastianoehm.bsky.social
Directed evolution of enzymatic silicon-carbon bond cleavage in siloxanes

www.science.org/doi/10.1126/...
February 1, 2024 at 10:49 AM
sebastianoehm.bsky.social
Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli

www.science.org/doi/10.1126/...
Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli
An Escherichia coli orthogonal replication system (EcORep) allows massively accelerated continuous evolution of introduced DNA in bacterial cells.
www.science.org
February 1, 2024 at 10:48 AM
sebastianoehm.bsky.social
Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism
www.nature.com/articles/s41...
Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism - Nature
tRNA display enables the direct selection of orthogonal aminoacyl-tRNA synthetases that acylate orthogonal tRNAs with non-canonical monomers, enabling in vivo synthesis of proteins that include t...
www.nature.com
February 1, 2024 at 10:48 AM