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We're looking for a potential PhD student to come explore the evolution of chromatin across eukaryotes in the @arnausebe.bsky.social lab! The project is flexible and a wide range of backgrounds will be considered! Please reach out if you have any questions. Link to application: shorturl.at/LlsJw

Since people should see and appreciate your artwork!

My favourite example is from the chytrid fungus S. punctatus, which has a near perfect colocalization of H3K9me3 and H3K27me3 encompassing both TEs and genes (reminiscent of the effect of the dual writing ability of Ezl1 in ciliates) 10/n

H3K79 methylation is written by a single enzyme, DOT1, and is associated with active gene bodies in fungi and animals. Surprisingly, while we saw dimethylation positively correlated with gene expression in the amoebazoan A. castellanii, trimethylation was negatively correlated! 7/n

Histone acetylation associated with genes is typically restricted to active gene TSSs, but in three distantly related species, an ichthyosporean, a chytrid fungus, and a flowering plant, we saw elevated levels of histone acetylation along the length of inactive or lowly expressed genes. 6/n

My lucky role was to play with the vast wealth of data! To start, we defined 19 metastates, similar ChromHMM chromatin states that represented distinct combinations of chromatin marks. We believe this can serve as a useful framework to directly compare chromatin landscapes across species. 4/n