@scientistjoanna.bsky.social
Reposted
🍰Interested in reading more about the study? Here's the N&Vs article written by Joanna R. Kovalski & Davide Ruggero.
👉https://rdcu.be/ejwqJ
bit.ly/4jnydWI
👉https://rdcu.be/ejwqJ
bit.ly/4jnydWI
Breaking up translation condensates in cancer - Nature Cell Biology
Translational control is emerging as a key regulator of cancer. The RNA-binding protein PABPC1 is shown to drive chronic myeloid leukaemia (CML) by enhancing the translation of pro-oncogenic mRNAs thr...
bit.ly
April 27, 2025 at 7:02 AM
🍰Interested in reading more about the study? Here's the N&Vs article written by Joanna R. Kovalski & Davide Ruggero.
👉https://rdcu.be/ejwqJ
bit.ly/4jnydWI
👉https://rdcu.be/ejwqJ
bit.ly/4jnydWI
This article hits the nail on the head for the challenges being manufactured in US scientific research especially for those of us early career folks.
America’s Brightest Minds Will Walk Away www.nytimes.com/2025/04/03/o...
America’s Brightest Minds Will Walk Away www.nytimes.com/2025/04/03/o...
Opinion | The Uncertain Fate of the Young American Scientist
Young researchers are choosing between staying in science and staying in the United States.
www.nytimes.com
April 4, 2025 at 12:29 AM
This article hits the nail on the head for the challenges being manufactured in US scientific research especially for those of us early career folks.
America’s Brightest Minds Will Walk Away www.nytimes.com/2025/04/03/o...
America’s Brightest Minds Will Walk Away www.nytimes.com/2025/04/03/o...
Not just "housekeeping." Targeting RNA translation is a specific vulnerability of prostate cancer cells. Exciting to see what's next on the horizon for small molecule RNA therapeutics.
Tumors overproduce the proteins that drive metabolism, cell division and more. A UCSF team has found that a breast cancer drug, zotatifin, jams the protein assembly line in prostate tumors – offering new hope for prostate cancer patients. tiny.ucsf.edu/665V7N
Researchers Learn How a Drug Called Zotatifin Kills Cancer Cells
A cancer drug developed ten years ago at UCSF can also put the brakes on one of prostate cancer's deadliest molecular tricks.
tiny.ucsf.edu
April 2, 2025 at 8:24 PM
Not just "housekeeping." Targeting RNA translation is a specific vulnerability of prostate cancer cells. Exciting to see what's next on the horizon for small molecule RNA therapeutics.
A powerful toolbox to study IRES-dependent selective translation of mRNAs. An important resource for the field! Excited to use these new tools to study a critical, yet under-appreciated mechanism of translational specificity. Congrats Barna and Leppek labs! #RNA
t.co/LmbFyKIfhh
t.co/LmbFyKIfhh
https://www.embopress.org/doi/full/10.1038/s44318-025-00404-5
t.co
March 13, 2025 at 3:55 PM
A powerful toolbox to study IRES-dependent selective translation of mRNAs. An important resource for the field! Excited to use these new tools to study a critical, yet under-appreciated mechanism of translational specificity. Congrats Barna and Leppek labs! #RNA
t.co/LmbFyKIfhh
t.co/LmbFyKIfhh
Stand Up For Science Rally Today at SF City Hall! Letting our voices be heard to keep hands off the NIH and keep pushing the bounds of human knowledge! 🔬🧪
March 8, 2025 at 1:31 AM
Stand Up For Science Rally Today at SF City Hall! Letting our voices be heard to keep hands off the NIH and keep pushing the bounds of human knowledge! 🔬🧪
We are grateful to @marasherman.bsky.social and Dr. Zainab Hussain for their insightful highlighting of our work out now in Nature Cell Biology.
🍰Interested in reading more about the study? Here is the N&Vs article written by Zainab Hussain & Mara H. Sherman.
👉🏽https://rdcu.be/ecb4q
bit.ly/43ljpme
👉🏽https://rdcu.be/ecb4q
bit.ly/43ljpme
Regulating MYC translation in cancer - Nature Cell Biology
Layered control of oncogenic protein dosage enables the hallmarks of cancer, but specific regulators of oncogene mRNA translation remain unknown. A study now reports RMB42 as a regulator of the MYC by...
bit.ly
March 6, 2025 at 3:13 AM
We are grateful to @marasherman.bsky.social and Dr. Zainab Hussain for their insightful highlighting of our work out now in Nature Cell Biology.
We are thrilled to share our discovery of a new factor, the RBP RBM42, which is key to fueling pancreas cancer through the deadly oncogene Myc. I look forward to what we uncover next! Thanks to the fantastic team lead by @DavideRuggero @rushika-perera.bsky.social & @genophoria.bsky.social!
☕️Kovalski et al. perform a genome-wide CRISPRi screen for selective MYC translation regulators and identify RBM42 as a ribosome-associated protein that modulates MYC translation and an #oncogenic mRNA program required for #PancreaticCancer growth.
👉🏼https://rdcu.be/ecb4e
bit.ly/41FKwY3
👉🏼https://rdcu.be/ecb4e
bit.ly/41FKwY3
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity - Nature Cell Biology
Kovalski et al. perform a genome-wide CRISPRi screen for selective MYC mRNA translation regulators and identify RBM42 as a ribosome-associated protein that modulates translation of MYC and an oncogeni...
bit.ly
March 6, 2025 at 3:11 AM
We are thrilled to share our discovery of a new factor, the RBP RBM42, which is key to fueling pancreas cancer through the deadly oncogene Myc. I look forward to what we uncover next! Thanks to the fantastic team lead by @DavideRuggero @rushika-perera.bsky.social & @genophoria.bsky.social!