Congratulations Johannes. A milestone work! Thanks for including us in this exciting project. We are always happy to assist! What a beautiful structure and amazing evolutionary implications.

Really looking forward to it. It's a great opportunity to meet friends and make new ones. We are also excited to present our latest structural work on the methyl branch of methanogens. Unpublished and highly exciting!

www.nature.com/articles/s41...
By any chance??? It is a cyanobacteria right?

Oh wow, let's hope with our new discoveries we don't outdate it too fast ;)

What an amazing portrait for such an great violinist and scientist. Very well done. And very nice ending 😁 with the final in the music 🎶

This method is an absolute game changer 🔥 when applied to bioenergetic problems. You should have a read. Wait for it 😶‍🌫️ great things are coming!!!

This work is a cornerstone in a long-term effort of the lab to understand the pumps of life. I call it a "Tripple in Bioenergetics" now.

The small protein MtrI blocks the Na+ binding subunit MtrCDE, bascially forming a plug for the channel. This could be important to prevent sodium leakage, when the complex gets damaged by oxygen.

The structure has also something for resolution fans! Such a nice coordinated sodium ion 😅

Tristan could show this by pull-down experiments. Irrespective of the growth condition, the oxygen sensitive behaviour was present.

This is a showcase study how small ORF proteins can regulate a central bioenergetic machinery. MtrI, binds here in a oxygen sensitive manner to the methyltransferase shuttle domain of MtrA.

Amazing paper, putting the spotlight on small proteins as modulators of the core bioenergetic machinery of methanogenesis.