Schuller Jan
@schullerjm.bsky.social
This work is a cornerstone in a long-term effort of the lab to understand the pumps of life. I call it a "Tripple in Bioenergetics" now.
June 4, 2025 at 8:01 PM
This work is a cornerstone in a long-term effort of the lab to understand the pumps of life. I call it a "Tripple in Bioenergetics" now.
The small protein MtrI blocks the Na+ binding subunit MtrCDE, bascially forming a plug for the channel. This could be important to prevent sodium leakage, when the complex gets damaged by oxygen.
June 4, 2025 at 7:57 PM
The small protein MtrI blocks the Na+ binding subunit MtrCDE, bascially forming a plug for the channel. This could be important to prevent sodium leakage, when the complex gets damaged by oxygen.
The structure has also something for resolution fans! Such a nice coordinated sodium ion 😅
June 4, 2025 at 7:56 PM
The structure has also something for resolution fans! Such a nice coordinated sodium ion 😅
Tristan could show this by pull-down experiments. Irrespective of the growth condition, the oxygen sensitive behaviour was present.
June 4, 2025 at 7:55 PM
Tristan could show this by pull-down experiments. Irrespective of the growth condition, the oxygen sensitive behaviour was present.
This is a showcase study how small ORF proteins can regulate a central bioenergetic machinery. MtrI, binds here in a oxygen sensitive manner to the methyltransferase shuttle domain of MtrA.
June 4, 2025 at 7:52 PM
This is a showcase study how small ORF proteins can regulate a central bioenergetic machinery. MtrI, binds here in a oxygen sensitive manner to the methyltransferase shuttle domain of MtrA.
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
June 4, 2025 at 7:10 PM
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
Happy to present the lab latest work, today from the green-side. The ultimate PSII assembly intermediate that directly precedes incorporation of the Mn4O5Ca cluster and formation of the OEC. Psb32 binds to PsbV, challenging the assumption the extrinsic subunits all associate spontaneously in-vivo.
May 12, 2025 at 5:50 AM
Happy to present the lab latest work, today from the green-side. The ultimate PSII assembly intermediate that directly precedes incorporation of the Mn4O5Ca cluster and formation of the OEC. Psb32 binds to PsbV, challenging the assumption the extrinsic subunits all associate spontaneously in-vivo.