👉 Dive into our full review to explore these mechanisms in detail, compare strategies across species, and see how understanding protein storage in oocytes could open new paths for fertility research.
Thanks to @idajentoft.bsky.social for your great work on this review. (5/5)

But oocytes face another challenge: protein damage accumulates during the mother’s life. Proteostasis systems clear or sequester damaged proteins ensuring a rejuvenated egg. Failure here may explain age-related fertility decline, as long-lived proteins lose stability and clearance falters. (4/5)

Across species, diverse strategies have evolved to store proteins, from large filamentous assemblies to membrane bound compartments. These systems prevent premature degradation and ensure key proteins are available when needed after fertilization. (3/5)

As transcription shuts down in growing oocytes, the egg relies on maternally deposited proteins and RNAs to drive early development, until the embryo can make its own.
But how do oocytes store these proteins? (2/5)

© Theodor Boveri Institut/Herr Dr. Brönner