Schuh Lab
@schuhlab.bsky.social
Illuminating the beginning of life at the Department of Meiosis, Max Planck Institute for Multidisciplinary Sciences @mpi-nat.bsky.social. Account managed by Melina and Vanessa @schuhlab.bsky.social
Last week, we enjoyed wonderful days on our #labretreat at Ringberg Castle by Lake Tegernsee, together with the Rink Lab and Lenart Lab from @mpi-nat.bsky.social. We explored science, hiked, did yoga, played games, and shared lots of laughter. A perfect setting to exchange ideas and connect. 🧠🧘♀️🎲
October 10, 2025 at 7:27 AM
Last week, we enjoyed wonderful days on our #labretreat at Ringberg Castle by Lake Tegernsee, together with the Rink Lab and Lenart Lab from @mpi-nat.bsky.social. We explored science, hiked, did yoga, played games, and shared lots of laughter. A perfect setting to exchange ideas and connect. 🧠🧘♀️🎲
Across species, diverse strategies have evolved to store proteins, from large filamentous assemblies to membrane bound compartments. These systems prevent premature degradation and ensure key proteins are available when needed after fertilization. (3/5)
October 8, 2025 at 12:50 PM
Across species, diverse strategies have evolved to store proteins, from large filamentous assemblies to membrane bound compartments. These systems prevent premature degradation and ensure key proteins are available when needed after fertilization. (3/5)
Feeling excited & grateful 🌟
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
September 17, 2025 at 7:26 AM
Feeling excited & grateful 🌟
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
Our fantastic technician Kevin marked his 30th birthday 🎉 and of course, the traditional German „fegen“ (sweeping) ritual was part of the celebration. Cheered on by colleagues, he handled it with humor and a great attitude.
Welcome to your thirties, Kevin! 🧹🎂🥳
Welcome to your thirties, Kevin! 🧹🎂🥳
August 13, 2025 at 1:13 PM
Our fantastic technician Kevin marked his 30th birthday 🎉 and of course, the traditional German „fegen“ (sweeping) ritual was part of the celebration. Cheered on by colleagues, he handled it with humor and a great attitude.
Welcome to your thirties, Kevin! 🧹🎂🥳
Welcome to your thirties, Kevin! 🧹🎂🥳
This week, Melina gave the Theodor Boveri Award Lecture at the University of Würzburg - the university’s highest honor in #lifesciences. This lecture recognizes outstanding scientists whose work continues Theodor Boveri’s pioneering legacy.
Congratulations to Melina for this well-deserved honor! 🎉
Congratulations to Melina for this well-deserved honor! 🎉
July 18, 2025 at 9:13 AM
This week, Melina gave the Theodor Boveri Award Lecture at the University of Würzburg - the university’s highest honor in #lifesciences. This lecture recognizes outstanding scientists whose work continues Theodor Boveri’s pioneering legacy.
Congratulations to Melina for this well-deserved honor! 🎉
Congratulations to Melina for this well-deserved honor! 🎉
Our PostDoc @debojitsaha.bsky.social recently attended a @cshlcourses.bsky.social & came back with new techniques and stunning images. This mouse E9.5 embryo, labeled with Raldh2 (red), Fgf8 (green), Msx1 (magenta), DAPI (blue) is just one example. #Fluorescence revealing the magic of development!✨
July 15, 2025 at 7:16 AM
Our PostDoc @debojitsaha.bsky.social recently attended a @cshlcourses.bsky.social & came back with new techniques and stunning images. This mouse E9.5 embryo, labeled with Raldh2 (red), Fgf8 (green), Msx1 (magenta), DAPI (blue) is just one example. #Fluorescence revealing the magic of development!✨
What an inspiring #NachtdesWissens @ndw-goe.bsky.social in Göttingen! Thanks to our amazing team, who made our research on oocytes 🥚 fun and accessible for everyone. Great to see so many #curiousminds exploring our science up close and joining in creative activities! 🖍️🧑🔬
June 24, 2025 at 10:12 AM
What an inspiring #NachtdesWissens @ndw-goe.bsky.social in Göttingen! Thanks to our amazing team, who made our research on oocytes 🥚 fun and accessible for everyone. Great to see so many #curiousminds exploring our science up close and joining in creative activities! 🖍️🧑🔬
It was great having Mariia @schuhlab for her lab rotation within the IMPRS Molecular Biology Master Program. She presented her project, supervised by @ninaschweizer.bsky.social, in our large seminar room.
Congratulations on sucessfully finishing - well done! 🎉
#researchtogether #posterpresentation
Congratulations on sucessfully finishing - well done! 🎉
#researchtogether #posterpresentation
May 28, 2025 at 6:44 AM
It was great having Mariia @schuhlab for her lab rotation within the IMPRS Molecular Biology Master Program. She presented her project, supervised by @ninaschweizer.bsky.social, in our large seminar room.
Congratulations on sucessfully finishing - well done! 🎉
#researchtogether #posterpresentation
Congratulations on sucessfully finishing - well done! 🎉
#researchtogether #posterpresentation
We had the pleasure of welcoming RTG2756 PhD students from @unigoettingen.bsky.social to our lab for a hands-on methods course. Great vibes, curious minds, and lots of good science – we truly enjoyed having you with us! 🧪🔬 #PhDLife #ScienceTogether
www.uni-goettingen.de/rtg2756
www.uni-goettingen.de/rtg2756
May 20, 2025 at 10:06 AM
We had the pleasure of welcoming RTG2756 PhD students from @unigoettingen.bsky.social to our lab for a hands-on methods course. Great vibes, curious minds, and lots of good science – we truly enjoyed having you with us! 🧪🔬 #PhDLife #ScienceTogether
www.uni-goettingen.de/rtg2756
www.uni-goettingen.de/rtg2756
New face in the lab! 😊
We're excited to welcome @palmrinmoy.bsky.social as a new postdoc in the Schuh Lab 🎉He completed his PhD in the Torres-Padilla lab @www.helmholtz-munich.de, studying early embryonic development. Now, he'll investigate long-lived proteins in oocytes. Great to have you here!
We're excited to welcome @palmrinmoy.bsky.social as a new postdoc in the Schuh Lab 🎉He completed his PhD in the Torres-Padilla lab @www.helmholtz-munich.de, studying early embryonic development. Now, he'll investigate long-lived proteins in oocytes. Great to have you here!
May 9, 2025 at 8:29 AM
New face in the lab! 😊
We're excited to welcome @palmrinmoy.bsky.social as a new postdoc in the Schuh Lab 🎉He completed his PhD in the Torres-Padilla lab @www.helmholtz-munich.de, studying early embryonic development. Now, he'll investigate long-lived proteins in oocytes. Great to have you here!
We're excited to welcome @palmrinmoy.bsky.social as a new postdoc in the Schuh Lab 🎉He completed his PhD in the Torres-Padilla lab @www.helmholtz-munich.de, studying early embryonic development. Now, he'll investigate long-lived proteins in oocytes. Great to have you here!
Looking back at #Zukunftstag2025, we’re still inspired by the curiosity & enthusiasm of the students! 🔬✨ From pipetting skills to microscopy & liquid nitrogen fun, it was an unforgettable day in the world of science. Thanks to all participants!🌟 #FutureScientists
April 17, 2025 at 6:07 AM
Looking back at #Zukunftstag2025, we’re still inspired by the curiosity & enthusiasm of the students! 🔬✨ From pipetting skills to microscopy & liquid nitrogen fun, it was an unforgettable day in the world of science. Thanks to all participants!🌟 #FutureScientists
Many congratulations to Jurgita on receiving the prestigious HFSP Postdoctoral Fellowship for her groundbreaking project on protein storage in mammalian #oocytes. Jurgita, we are so proud of you for this well-deserved recognition! Stay tuned to follow her exciting research journey! 🏆🌟
April 10, 2025 at 7:00 AM
Many congratulations to Jurgita on receiving the prestigious HFSP Postdoctoral Fellowship for her groundbreaking project on protein storage in mammalian #oocytes. Jurgita, we are so proud of you for this well-deserved recognition! Stay tuned to follow her exciting research journey! 🏆🌟
Fascination with science on #Zukunftstag2025! 🧬👩🔬 Today, we explored the world of #science with students in our demo lab – examining oocytes under the microscope, extracting DNA, practicing pipetting, and even dipping gummybears in liquid nitrogen! 🧪 A day full of discoveries!
April 3, 2025 at 1:32 PM
Fascination with science on #Zukunftstag2025! 🧬👩🔬 Today, we explored the world of #science with students in our demo lab – examining oocytes under the microscope, extracting DNA, practicing pipetting, and even dipping gummybears in liquid nitrogen! 🧪 A day full of discoveries!
We’re excited to welcome Dr. Vanessa Hindmarsh as our new #ScientificManager! With a PhD in Molecular Medicine and experience in digital marketing & e-commerce, she will support Melina and manage our social media presence to share more about our work. Stay tuned for lab updates! 🔬🧬
March 24, 2025 at 8:00 AM
We’re excited to welcome Dr. Vanessa Hindmarsh as our new #ScientificManager! With a PhD in Molecular Medicine and experience in digital marketing & e-commerce, she will support Melina and manage our social media presence to share more about our work. Stay tuned for lab updates! 🔬🧬
Our findings explain why shorter acrocentric chromosomes, like #21 in Down syndrome, often mis-segregate.
Their unique shape and reduced cohesion create challenges during oocyte division, increasing error rates. (8/9)
Their unique shape and reduced cohesion create challenges during oocyte division, increasing error rates. (8/9)
December 23, 2024 at 1:22 PM
Our findings explain why shorter acrocentric chromosomes, like #21 in Down syndrome, often mis-segregate.
Their unique shape and reduced cohesion create challenges during oocyte division, increasing error rates. (8/9)
Their unique shape and reduced cohesion create challenges during oocyte division, increasing error rates. (8/9)
Acrocentric chromosomes also have lower levels of cohesion proteins (Smc3 and Rec8) compared to metacentric ones.
This reduced cohesion likely makes them more vulnerable to age-related aneuploidy. (7/9)
This reduced cohesion likely makes them more vulnerable to age-related aneuploidy. (7/9)
December 23, 2024 at 1:22 PM
Acrocentric chromosomes also have lower levels of cohesion proteins (Smc3 and Rec8) compared to metacentric ones.
This reduced cohesion likely makes them more vulnerable to age-related aneuploidy. (7/9)
This reduced cohesion likely makes them more vulnerable to age-related aneuploidy. (7/9)
We extended our analysis to human oocytes and found similar telomere-masked kinetochores.
This confirms that chromosome shape influences mis-segregation across species, including humans. (6/9)
This confirms that chromosome shape influences mis-segregation across species, including humans. (6/9)
December 23, 2024 at 1:22 PM
We extended our analysis to human oocytes and found similar telomere-masked kinetochores.
This confirms that chromosome shape influences mis-segregation across species, including humans. (6/9)
This confirms that chromosome shape influences mis-segregation across species, including humans. (6/9)
Using STED microscopy, we found that acrocentric kinetochores struggle more to orient towards the spindle pole compared to metacentric ones.
This highlights the structural challenges these chromosomes face during division. (5/9)
This highlights the structural challenges these chromosomes face during division. (5/9)
December 23, 2024 at 1:22 PM
Using STED microscopy, we found that acrocentric kinetochores struggle more to orient towards the spindle pole compared to metacentric ones.
This highlights the structural challenges these chromosomes face during division. (5/9)
This highlights the structural challenges these chromosomes face during division. (5/9)
Acrocentric chromosomes form incorrect attachments to spindle fibers more often in meiosis I. This difference vanishes in meiosis II.
The small arm of acrocentric chromosomes partially covers the kinetochore in meiosis I, making correct attachments harder. (4/9)
The small arm of acrocentric chromosomes partially covers the kinetochore in meiosis I, making correct attachments harder. (4/9)
December 23, 2024 at 1:22 PM
Acrocentric chromosomes form incorrect attachments to spindle fibers more often in meiosis I. This difference vanishes in meiosis II.
The small arm of acrocentric chromosomes partially covers the kinetochore in meiosis I, making correct attachments harder. (4/9)
The small arm of acrocentric chromosomes partially covers the kinetochore in meiosis I, making correct attachments harder. (4/9)
Live imaging showed acrocentric chromosomes frequently misaligned and lagged during division. They're 7 times more likely to mis-segregate than metacentric ones in pig eggs.
Turns out shape matters! But how? (3/9)
Turns out shape matters! But how? (3/9)
December 23, 2024 at 1:22 PM
Live imaging showed acrocentric chromosomes frequently misaligned and lagged during division. They're 7 times more likely to mis-segregate than metacentric ones in pig eggs.
Turns out shape matters! But how? (3/9)
Turns out shape matters! But how? (3/9)
We labeled acrocentric (centromere near one end) and metacentric (centromere in middle) chromosomes in live pig oocytes to compare their behavior during meiosis.
Using sequence-specific tags, we tracked these chromosomes to understand how their shape influences segregation. (2/9)
Using sequence-specific tags, we tracked these chromosomes to understand how their shape influences segregation. (2/9)
December 23, 2024 at 1:22 PM
We labeled acrocentric (centromere near one end) and metacentric (centromere in middle) chromosomes in live pig oocytes to compare their behavior during meiosis.
Using sequence-specific tags, we tracked these chromosomes to understand how their shape influences segregation. (2/9)
Using sequence-specific tags, we tracked these chromosomes to understand how their shape influences segregation. (2/9)
Why are some chromosomes like #21 in Down syndrome more error-prone in mammalian eggs? 🤔
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
December 23, 2024 at 1:22 PM
Why are some chromosomes like #21 in Down syndrome more error-prone in mammalian eggs? 🤔
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9)
www.nature.com/articles/s41...
We found two mechanisms repressing cyclin B1 translation to sustain prophase arrest: 1) A DDX6-containing complex directly blocks cyclin B1 translation. 2) PABPCs sequester translation machinery on long-tailed mRNAs, indirectly repressing short-tailed mRNAs like cyclin B1. (6/6)
December 11, 2024 at 4:22 PM
We found two mechanisms repressing cyclin B1 translation to sustain prophase arrest: 1) A DDX6-containing complex directly blocks cyclin B1 translation. 2) PABPCs sequester translation machinery on long-tailed mRNAs, indirectly repressing short-tailed mRNAs like cyclin B1. (6/6)
By expressing mRNAs with different poly(A) tail lengths, we found that PABPC Trim-Away caused a shift of translation from long-tailed to tailless and short-tailed mRNAs. This explains why PABPC Trim-Away increased the translation of cyclin B1 which has a short poly(A) tail. (5/6)
December 11, 2024 at 4:21 PM
By expressing mRNAs with different poly(A) tail lengths, we found that PABPC Trim-Away caused a shift of translation from long-tailed to tailless and short-tailed mRNAs. This explains why PABPC Trim-Away increased the translation of cyclin B1 which has a short poly(A) tail. (5/6)
The stored dormant cyclin B1 mRNA contains a short poly(A) tail. Poly(A) tail usually promotes translation by recruiting cytoplasmic poly(A)-binding proteins (PABPC). Surprisingly, PABPC Trim-Away also caused premature cyclin B1 translation and meiotic resumption. (4/6)
December 11, 2024 at 4:21 PM
The stored dormant cyclin B1 mRNA contains a short poly(A) tail. Poly(A) tail usually promotes translation by recruiting cytoplasmic poly(A)-binding proteins (PABPC). Surprisingly, PABPC Trim-Away also caused premature cyclin B1 translation and meiotic resumption. (4/6)