Scheiffele Lab
@scheiffelelab.bsky.social
neuroscientist, autism and RNA researcher, mountain lover, super dad
Reposted by Scheiffele Lab
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation
Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…
www.sciencedirect.com
June 11, 2025 at 11:34 AM
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Great Lab and a great project!
Postdoc position: Synaptic specificity in cortical and thalamocortical circuits - VIB
Overview
The VIB-KU Leuven Center for Brain & Disease Research is part of the VIB Life Sciences Institute and is embedded within the KU Leuven, which ranks among the world’s top 50 universities. At ou...
jobs.vib.be
March 24, 2025 at 12:24 PM
Great Lab and a great project!
Same here -
How Canadians Are Directing Their Ire at the U.S. Over Trump’s Tariffs
Canadians are shunning American products and abandoning trips to the United States to protest the economic punishment President Trump has threatened to impose with tariffs.
www.nytimes.com
February 28, 2025 at 8:01 PM
Same here -
Interesting integration of transcriptomic and imaging data from zebrafish optic tectum cells!
Transcriptomic neuron types vary topographically in function and morphology - Nature
Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of specific cell t...
www.nature.com
February 27, 2025 at 2:36 PM
Interesting integration of transcriptomic and imaging data from zebrafish optic tectum cells!
Important article on the urgent question how to upkeep key information platforms for science
Science must step away from nationally managed infrastructure
Scientific data and independence are at risk. We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political…
www.thetransmitter.org
February 21, 2025 at 12:42 PM
Important article on the urgent question how to upkeep key information platforms for science
Super-interesting new preprint from the Greenberg lab on a systematic analysis of plasticity-associated gene regulation!
Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus
Curiosity-driven interactions with novel cues in our environment represent a common behavioral trait across the animal kingdom. Exposure to a novel environment (NE) reshapes the brain by promoting str...
www.biorxiv.org
February 12, 2025 at 6:47 AM
Super-interesting new preprint from the Greenberg lab on a systematic analysis of plasticity-associated gene regulation!
Exciting job opportunity in Europe!
Group Leader - Molecular Mechanisms of Environmental Adaptation
We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...
embl.wd103.myworkdayjobs.com
February 12, 2025 at 6:43 AM
Exciting job opportunity in Europe!
Reposted by Scheiffele Lab
Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins https://www.biorxiv.org/content/10.1101/2025.01.15.633116v1
January 16, 2025 at 7:33 AM
Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins https://www.biorxiv.org/content/10.1101/2025.01.15.633116v1
Beautiful example of spatial proteomic dissection
of synapse diversity from De Wit Lab!
of synapse diversity from De Wit Lab!
Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons - PubMed
Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. Their morphology, connectivity, electrophysiological properties...
pubmed.ncbi.nlm.nih.gov
February 10, 2025 at 3:09 PM
Beautiful example of spatial proteomic dissection
of synapse diversity from De Wit Lab!
of synapse diversity from De Wit Lab!
Reposted by Scheiffele Lab
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 29, 2025 at 7:08 AM
Reposted by Scheiffele Lab
Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions.
springernature.wd3.myworkdayjobs.com/SpringerNatu...
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Associate or Senior Editor, Nature Neuroscience
Job Title: Associate or Senior Editor, Nature Neuroscience Location: New York, Jersey City, Philadelphia, Washington D.C., Berlin or Shanghai Application Deadline: January 6, 2025 About Springer Natur...
springernature.wd3.myworkdayjobs.com
December 9, 2024 at 3:36 PM
Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions.
springernature.wd3.myworkdayjobs.com/SpringerNatu...
springernature.wd3.myworkdayjobs.com/SpringerNatu...
…and another cool approach to uncover RNA-RNA interactions !
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification
Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions,
which facilitate nascent protein translocation to the ER and subsequent secretion.
www.cell.com
November 25, 2024 at 8:50 PM
…and another cool approach to uncover RNA-RNA interactions !
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Cool method!
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes
Al-Azzam et al. reveal that SmD1, a member of the SMN complex, regulates CHMP7 translocation.
Reduced SmD1 expression in sporadic ALS leads to CHMP7 nuclear translocation, while
overexpression prevent...
www.cell.com
November 25, 2024 at 8:44 PM
Cool method!
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Scheiffele Lab
"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The lives of cells, recorded - Nature Reviews Genetics
Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...
www.nature.com
November 25, 2024 at 5:29 PM
"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Want a job in an exciting, science-driven environment? Genome Biology Unit Group leader call at EMBL Heidelberg:
www.embl.org/jobs/positio...
www.embl.org/jobs/positio...
EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
www.embl.org
November 18, 2024 at 9:03 PM
Want a job in an exciting, science-driven environment? Genome Biology Unit Group leader call at EMBL Heidelberg:
www.embl.org/jobs/positio...
www.embl.org/jobs/positio...
Looking forward to AXON2025 - mark your calendars
November 17, 2024 at 10:49 AM
Looking forward to AXON2025 - mark your calendars
Gold nugget?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Quantitative Comparison of Monomeric StayGold Variants Using Protein Nanocages in Living Cells
To standardize comparison of fluorescent proteins and independently determine which monomeric StayGold variant is best for live microscopy, we analyzed fluorescent protein tagged I3-01 peptides that s...
www.biorxiv.org
November 13, 2024 at 9:33 PM
Gold nugget?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Apply for our PhD program - great rotation system and great labs!
www.biozentrum.unibas.ch/phd/internat...
www.biozentrum.unibas.ch/phd/internat...
Biozentrum PhD Fellowships Program
The Biozentrum encourages talented, ambitious and highly motivated young scientists from all over the world to apply for the prestigious and sought after fellowships offered by the Biozentrum Basel In...
www.biozentrum.unibas.ch
November 13, 2024 at 12:20 PM
Apply for our PhD program - great rotation system and great labs!
www.biozentrum.unibas.ch/phd/internat...
www.biozentrum.unibas.ch/phd/internat...
November 13, 2024 at 9:59 AM