Sam Barnett Dubensky
@sbarnettdubensky.bsky.social
MD/PhD Student at the University of Pennsylvania
Derek Oldridge & Laura Vella Labs, Children's Hospital of Philadelphia
orcid.org/0000-0001-9799-8089
Interests - Germinal Center Biology | Human Immunology | Spatial & Single-Cell Omics | Really Good Bread
Derek Oldridge & Laura Vella Labs, Children's Hospital of Philadelphia
orcid.org/0000-0001-9799-8089
Interests - Germinal Center Biology | Human Immunology | Spatial & Single-Cell Omics | Really Good Bread
Pinned
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans
CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expressi...
bit.ly
T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI
Reposted by Sam Barnett Dubensky
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.6... @lauravella.bsky.social @derek-oldridge.bsky.social @pennmedicine.bsky.social
www.biorxiv.org/content/10.6... @lauravella.bsky.social @derek-oldridge.bsky.social @pennmedicine.bsky.social
December 16, 2025 at 5:30 PM
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.6... @lauravella.bsky.social @derek-oldridge.bsky.social @pennmedicine.bsky.social
www.biorxiv.org/content/10.6... @lauravella.bsky.social @derek-oldridge.bsky.social @pennmedicine.bsky.social
Reposted by Sam Barnett Dubensky
Really excited to share this work from the @laura-a-vella.bsky.social and @derek-oldridge.bsky.social labs, led by an amazing MD/PhD student! Sam asked if Tfh spatially localised within germinal centers have distinct gene expression programs & identified GNG4 as a key feature of GC-positioned Tfh.
T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans
CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expressi...
bit.ly
December 16, 2025 at 7:08 PM
Really excited to share this work from the @laura-a-vella.bsky.social and @derek-oldridge.bsky.social labs, led by an amazing MD/PhD student! Sam asked if Tfh spatially localised within germinal centers have distinct gene expression programs & identified GNG4 as a key feature of GC-positioned Tfh.
Reposted by Sam Barnett Dubensky
I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses
This study dissects the individual contributions of the different components of mRNA
vaccines to immune responses. Nucleoside-modified mRNA promotes the production of
type I interferons that act on de...
www.cell.com
December 16, 2025 at 5:40 PM
I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
Reposted by Sam Barnett Dubensky
@biorxivpreprint.bsky.social Dysregulated localization of Tfh and B cells in lymph nodes of Idiopathic multicentric Castleman disease patients
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
December 16, 2025 at 4:30 AM
@biorxivpreprint.bsky.social Dysregulated localization of Tfh and B cells in lymph nodes of Idiopathic multicentric Castleman disease patients
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
Reposted by Sam Barnett Dubensky
T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans
CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expressi...
bit.ly
December 15, 2025 at 5:03 PM
T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI
Reposted by Sam Barnett Dubensky
Very proud to share Sam’s work, jointly supervised between @laura-a-vella.bsky.social and my lab. His work exemplifies how to leverage the power of single-cell and spatialomics to uncover new insights into human GC Tfh biology and why studying human immunology matters:
bsky.app/profile/sbar...
bsky.app/profile/sbar...
T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans
CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expressi...
bit.ly
December 15, 2025 at 10:29 PM
Very proud to share Sam’s work, jointly supervised between @laura-a-vella.bsky.social and my lab. His work exemplifies how to leverage the power of single-cell and spatialomics to uncover new insights into human GC Tfh biology and why studying human immunology matters:
bsky.app/profile/sbar...
bsky.app/profile/sbar...
Reposted by Sam Barnett Dubensky
Incredibly happy to share Sam’s work between my lab and that of @derek-oldridge.bsky.social. What cellular programs are engaged by GC-positioned human Tfh? The answers held a few surprises.
T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans
CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expressi...
bit.ly
December 15, 2025 at 9:19 PM
Incredibly happy to share Sam’s work between my lab and that of @derek-oldridge.bsky.social. What cellular programs are engaged by GC-positioned human Tfh? The answers held a few surprises.
Reposted by Sam Barnett Dubensky
Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease https://www.biorxiv.org/content/10.64898/2025.12.12.693846v1
December 15, 2025 at 6:16 PM
Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease https://www.biorxiv.org/content/10.64898/2025.12.12.693846v1
Reposted by Sam Barnett Dubensky
Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease https://www.biorxiv.org/content/10.64898/2025.12.12.693846v1
December 15, 2025 at 6:16 PM
Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease https://www.biorxiv.org/content/10.64898/2025.12.12.693846v1
T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans
CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expressi...
bit.ly
December 15, 2025 at 5:03 PM
T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI
Reposted by Sam Barnett Dubensky
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans https://www.biorxiv.org/content/10.64898/2025.12.10.693235v1
December 13, 2025 at 10:16 PM
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans https://www.biorxiv.org/content/10.64898/2025.12.10.693235v1
Reposted by Sam Barnett Dubensky
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans https://www.biorxiv.org/content/10.64898/2025.12.10.693235v1
December 13, 2025 at 10:16 PM
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans https://www.biorxiv.org/content/10.64898/2025.12.10.693235v1