Sara McArdle
@saramcardle.bsky.social
Staff Scientist at the La Jolla Institute Microscopy and Histology Facility. I love cat videos and microscopy images and I believe that Matlab is better than Python :)
There's an XKCD about that!
xkcd.com/606/
xkcd.com/606/
Cutting Edge
xkcd.com
October 24, 2025 at 4:24 PM
There's an XKCD about that!
xkcd.com/606/
xkcd.com/606/
I want to thank all of the co-authors, though I can't find any of them are on bluesky. In particular, I want to thank Priyanka Saminathan for all her work getting this to the finish line!
October 8, 2025 at 5:18 PM
I want to thank all of the co-authors, though I can't find any of them are on bluesky. In particular, I want to thank Priyanka Saminathan for all her work getting this to the finish line!
All of the segmentation and morphometric analysis was done with the open-source platform QuPath. The scripts I wrote are on Github and the raw images are on the BioImage Archive, because open-source is the way to go!
But seriously, look at these cells! They are so angry.
But seriously, look at these cells! They are so angry.
October 8, 2025 at 5:18 PM
All of the segmentation and morphometric analysis was done with the open-source platform QuPath. The scripts I wrote are on Github and the raw images are on the BioImage Archive, because open-source is the way to go!
But seriously, look at these cells! They are so angry.
But seriously, look at these cells! They are so angry.
We used widefield slidescanning + deconvolution + Z projection to image microglia in the hippocampus. 2 years in with ~11000 cell analyzed and I'm still not over how pretty microglia can be.
We found signs that glia in female AD mice begin to react to *something* before there are even plaques.
We found signs that glia in female AD mice begin to react to *something* before there are even plaques.
October 8, 2025 at 5:18 PM
We used widefield slidescanning + deconvolution + Z projection to image microglia in the hippocampus. 2 years in with ~11000 cell analyzed and I'm still not over how pretty microglia can be.
We found signs that glia in female AD mice begin to react to *something* before there are even plaques.
We found signs that glia in female AD mice begin to react to *something* before there are even plaques.
Reposted by Sara McArdle
Lip Sync Battle - Tom Holland
YouTube video by Comedy Central Latinoamérica
youtu.be
September 29, 2025 at 12:31 AM
Chaotic good! I honestly spent 5 minutes debating whether hdf5 or ome.zarr was more chaotic
August 8, 2025 at 6:53 PM
Chaotic good! I honestly spent 5 minutes debating whether hdf5 or ome.zarr was more chaotic
Yea, true. But I'm not sure it's more evil than the other 3.
August 8, 2025 at 2:12 PM
Yea, true. But I'm not sure it's more evil than the other 3.
The original NIH Image from 1987 recommended 4 MB of RAM!
July 7, 2025 at 11:27 PM
The original NIH Image from 1987 recommended 4 MB of RAM!
Reposted by Sara McArdle
It's not that we might lose our jobs. It's that all of it will disappear or mutate beyond recognition. I worry we're not talking or thinking enough about this deeper sadness hiding behind our immediate anxieties and it's this heaviness that has us all at a breaking point.
May 15, 2025 at 2:35 AM
It's not that we might lose our jobs. It's that all of it will disappear or mutate beyond recognition. I worry we're not talking or thinking enough about this deeper sadness hiding behind our immediate anxieties and it's this heaviness that has us all at a breaking point.