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sarahhowles.bsky.social
Sarah Howles
@sarahhowles.bsky.social
180 followers 740 following 6 posts
Academic urologist trying to understand kidney stones. University of Oxford
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Reposted by Sarah Howles
natrevneph.nature.com
Kidney stone disease: risk factors, pathophysiology and management go.nature.com/47hmWEe

@danfuster.bsky.social
@sarahhowles.bsky.social
Kidney stone disease: risk factors, pathophysiology and management - Nature Reviews Nephrology
This Review discusses the pathophysiology of kidney stone formation and examines the contribution of urinary risk factors and genetic variants. The authors also consider current approaches to the mana...
go.nature.com
August 27, 2025 at 9:37 AM
Reposted by Sarah Howles
jci.org
No stone goes unturned in the search for risk-associated variants in kidney stone disease—

@celovegrove.bsky.social @sarahhowles.bsky.social & team identify three biologic pathways that underlie ~11-19% of common causes of stone formation: buff.ly/INjAjLy
August 9, 2025 at 12:04 PM
sarahhowles.bsky.social
Our latest with editorial. Genetic susceptibility to kidney stone disease: unveiling pathogenesis and potential therapeutic targets @jclinicalinvest @drsarahhowles
jci.org/articles/view/…
jci.org/articles/view/��� @celovegrove.bsky.social @ndsurgicalsci.bsky.social
https://jci.org/articles/view/…
August 6, 2025 at 6:47 AM
Reposted by Sarah Howles
celovegrove.bsky.social
Important work from Grace Wheeler, Victor Popoola, & @sarahhowles.bsky.social from @ox.ac.uk & @ndsurgicalsci.bsky.social in @collegeofsurgeons.bsky.social supported by @kidneyresearchuk.org, @wellcometrust.bsky.social, Medical Research Council, & @oxhealthbrc.bsky.social.

Plenty more work to do!
July 15, 2025 at 4:32 PM
Reposted by Sarah Howles
celovegrove.bsky.social
www.kidneyresearchuk.org/2025/07/01/r...
“By identifying 3 changes in 🧬 that ⬆️ the risk of kidney stones, it may be possible to use this info, alongside other risk factors, to provide personalised treatments for patients. ”

@kidneyresearchuk.org @sarahhowles.bsky.social @ndsurgicalsci.bsky.social
Research uncovers genetic changes linked to developing kidney stones - Kidney Research UK
Researchers have discovered DNA changes that likely control people’s calcium and phosphate levels and cause kidney stones.
www.kidneyresearchuk.org
July 4, 2025 at 8:53 PM
sarahhowles.bsky.social
www.nature.com/articles/s41...
Rare disease gene association discovery in the 100,000 Genomes Project - Nature
A rare variant burden analytical framework for Mendelian diseases was developed and applied to data from the 100,000 Genomes Project, identifying 69 probable new disease–gene associations.
www.nature.com
February 26, 2025 at 6:47 PM
Reposted by Sarah Howles
bursturology.bsky.social
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#UroSoMe #Urology #Research
February 1, 2025 at 7:45 AM
Reposted by Sarah Howles
nephmoor.bsky.social
It’s now online! Published today at www.nature.com/articles/s41...
Empagliflozin in nondiabetic individuals with calcium and uric acid kidney stones: a randomized phase 2 trial - Nature Medicine
As part of the SWEETSTONE trial, the authors report the ability of the sodium-glucose cotransporter 2 inhibitor empagliflozin to reduce the likelihood of kidney stone formation in individuals without ...
eur01.safelinks.protection.outlook.com
January 2, 2025 at 5:27 PM
Reposted by Sarah Howles
doctorveera.bsky.social
One of the underrated uses of plasma proteins is disease prediction. They predict most disease conditions surprisingly well, even better than demographics model. The plot compares AUC of plasma protein risk scores vs demographics in predicting disease endpoints in the UK Biobank.
November 28, 2024 at 5:24 PM